Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Elizabeth City State | 55 | 83 | North Carolina (33) | Final | W | 28 |
| 2 | 2021-11-09 | Loyola-Maryland (183) | 67 | 83 | North Carolina (33) | Final | W | 16 |
| 3 | 2021-11-12 | Brown (295) | 87 | 94 | North Carolina (22) | Final | W | 7 |
| 4 | 2021-11-16 | North Carolina (54) | 94 | 83 | Charleston (26) | Final | W | 11 |
| 5 | 2021-11-20 | Purdue (8) | 93 | 84 | North Carolina (22) | Final | L | -9 |
| 6 | 2021-11-21 | Tennessee (65) | 89 | 72 | North Carolina (103) | Final | L | -17 |
| 7 | 2021-11-23 | UNC-Asheville (210) | 53 | 72 | North Carolina (103) | Final | W | 19 |
| 8 | 2021-12-01 | Michigan (1) | 51 | 72 | North Carolina (22) | Final | W | 21 |
| 9 | 2021-12-05 | North Carolina (77) | 79 | 62 | Georgia Tech (89) | Final | W | 17 |
| 10 | 2021-12-11 | Elon (232) | 63 | 80 | North Carolina (22) | Final | W | 17 |
| 11 | 2021-12-14 | Furman (157) | 61 | 74 | North Carolina (22) | Final | W | 13 |
| 12 | 2021-12-18 | North Carolina (22) | 69 | 98 | Kentucky (26) | Final | L | -29 |
| 13 | 2021-12-18 | North Carolina | 0 | 0 | UCLA | Cancelled | - | - |
| 14 | 2021-12-21 | Appalachian State (159) | 50 | 70 | North Carolina (22) | Final | W | 20 |
| 15 | 2021-12-29 | Virginia Tech (56) | 0 | 0 | North Carolina (22) | Postponed | - | - |
| 16 | 2022-01-02 | North Carolina (22) | 91 | 65 | Boston College (151) | Final | W | 26 |
| 17 | 2022-01-05 | North Carolina (22) | 73 | 78 | Notre Dame (101) | Final | L | -5 |
| 18 | 2022-01-08 | Virginia (14) | 58 | 74 | North Carolina (22) | Final | W | 16 |
| 19 | 2022-01-15 | Georgia Tech (158) | 65 | 88 | North Carolina (22) | Final | W | 23 |
| 20 | 2022-01-18 | North Carolina (22) | 57 | 85 | Miami (27) | Final | L | -28 |
| 21 | 2022-01-22 | North Carolina (22) | 76 | 98 | Wake Forest (70) | Final | L | -22 |
| 22 | 2022-01-24 | Virginia Tech (56) | 68 | 78 | North Carolina (22) | Final | W | 10 |
| 23 | 2022-01-26 | Boston College (167) | 47 | 58 | North Carolina (56) | Final | W | 11 |
| 24 | 2022-01-29 | North Carolina State (44) | 80 | 100 | North Carolina (22) | Final | W | 20 |
| 25 | 2022-02-01 | North Carolina (45) | 90 | 83 | Louisville (112) | Final (OT) | W | 7 |
| 26 | 2022-02-05 | Duke (3) | 87 | 67 | North Carolina (22) | Final | L | -20 |
| 27 | 2022-02-08 | North Carolina (41) | 79 | 77 | Clemson (98) | Final | W | 2 |
| 28 | 2022-02-12 | Florida State (64) | 74 | 94 | North Carolina (22) | Final | W | 20 |
| 29 | 2022-02-16 | Pittsburgh (162) | 76 | 67 | North Carolina (33) | Final | L | -9 |
| 30 | 2022-02-19 | North Carolina (33) | 65 | 57 | Virginia Tech (71) | Final | W | 8 |
| 31 | 2022-02-21 | Louisville (117) | 63 | 70 | North Carolina (39) | Final | W | 7 |
| 32 | 2022-02-26 | North Carolina (39) | 84 | 74 | North Carolina State (137) | Final | W | 10 |
| 33 | 2022-02-28 | Syracuse (96) | 79 | 88 | North Carolina (39) | Final | W | 9 |
| 34 | 2022-03-05 | North Carolina (39) | 94 | 81 | Duke (8) | Final | W | 13 |
| 35 | 2022-03-10 | Virginia (77) | 43 | 63 | North Carolina (29) | Final | W | 20 |
| 36 | 2022-03-11 | Virginia Tech (62) | 72 | 59 | North Carolina (29) | Final | L | -13 |
| 37 | 2022-03-17 | Marquette (36) | 63 | 95 | North Carolina (31) | Final | W | 32 |
| 38 | 2022-03-19 | North Carolina (31) | 93 | 86 | Baylor (4) | Final (OT) | W | 7 |
| 39 | 2022-03-25 | North Carolina (31) | 73 | 66 | UCLA (10) | Final | W | 7 |
| 40 | 2022-03-27 | Saint Peter's (128) | 49 | 69 | North Carolina (31) | Final | W | 20 |
| 41 | 2022-04-02 | North Carolina (31) | 81 | 77 | Duke (13) | Final | W | 4 |
| 42 | 2022-04-04 | North Carolina (31) | 69 | 72 | Kansas (3) | Final | L | -3 |