Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Michigan (4) | 87 | 54 | Wayne State | Final | W | 33 |
| 2 | 2021-11-10 | Buffalo (99) | 76 | 88 | Michigan (4) | Final | W | 12 |
| 3 | 2021-11-13 | Prairie View A&M (168) | 49 | 77 | Michigan (4) | Final | W | 28 |
| 4 | 2021-11-16 | Seton Hall (2) | 67 | 65 | Michigan (72) | Final | L | -2 |
| 5 | 2021-11-19 | Michigan (1) | 74 | 61 | UNLV (105) | Final | W | 13 |
| 6 | 2021-11-20 | UNLV (96) | 61 | 74 | Michigan (72) | Final | W | 13 |
| 7 | 2021-11-21 | Michigan (67) | 62 | 80 | Arizona (1) | Final | L | -18 |
| 8 | 2021-11-24 | Tarleton State (234) | 54 | 65 | Michigan (1) | Final | W | 11 |
| 9 | 2021-12-01 | Michigan (1) | 51 | 72 | North Carolina (22) | Final | L | -21 |
| 10 | 2021-12-04 | San Diego State (48) | 58 | 72 | Michigan (1) | Final | W | 14 |
| 11 | 2021-12-07 | Michigan (1) | 102 | 67 | Nebraska (13) | Final | W | 35 |
| 12 | 2021-12-11 | Minnesota (87) | 75 | 65 | Michigan (1) | Final | L | -10 |
| 13 | 2021-12-18 | Southern Utah (282) | 50 | 87 | Michigan (1) | Final | W | 37 |
| 14 | 2021-12-21 | Purdue Fort Wayne (222) | 0 | 0 | Michigan (1) | Cancelled | - | - |
| 15 | 2021-12-30 | Michigan (1) | 71 | 85 | Central Florida (43) | Final | L | -14 |
| 16 | 2022-01-04 | Michigan (1) | 67 | 75 | Rutgers (112) | Final | L | -8 |
| 17 | 2022-01-08 | Michigan State (10) | 0 | 0 | Michigan (1) | Postponed | - | - |
| 18 | 2022-01-11 | Purdue (8) | 0 | 0 | Michigan (1) | Postponed | - | - |
| 19 | 2022-01-14 | Michigan (77) | 53 | 68 | Illinois (23) | Final | L | -15 |
| 20 | 2022-01-18 | Maryland (114) | 64 | 83 | Michigan (1) | Final | W | 19 |
| 21 | 2022-01-23 | Michigan (63) | 80 | 62 | Indiana (42) | Final | W | 18 |
| 22 | 2022-01-26 | Northwestern (94) | 70 | 72 | Michigan (63) | Final | W | 2 |
| 23 | 2022-01-29 | Michigan (1) | 67 | 83 | Michigan State (10) | Final | L | -16 |
| 24 | 2022-02-01 | Nebraska (197) | 79 | 85 | Michigan (66) | Final | W | 6 |
| 25 | 2022-02-05 | Michigan (1) | 76 | 82 | Purdue (8) | Final | L | -6 |
| 26 | 2022-02-08 | Michigan (64) | 58 | 57 | Penn State (83) | Final | W | 1 |
| 27 | 2022-02-10 | Purdue (8) | 58 | 82 | Michigan (1) | Final | W | 24 |
| 28 | 2022-02-12 | Ohio State (34) | 68 | 57 | Michigan (1) | Final | L | -11 |
| 29 | 2022-02-17 | Michigan (1) | 84 | 79 | Iowa (28) | Final | W | 5 |
| 30 | 2022-02-20 | Michigan (44) | 63 | 77 | Wisconsin (15) | Final | L | -14 |
| 31 | 2022-02-23 | Rutgers (69) | 62 | 71 | Michigan (44) | Final | W | 9 |
| 32 | 2022-02-27 | Illinois (20) | 93 | 85 | Michigan (45) | Final | L | -8 |
| 33 | 2022-03-01 | Michigan State (28) | 70 | 87 | Michigan (45) | Final | W | 17 |
| 34 | 2022-03-03 | Iowa (26) | 82 | 71 | Michigan (45) | Final | L | -11 |
| 35 | 2022-03-06 | Michigan (41) | 75 | 69 | Ohio State (30) | Final | W | 6 |
| 36 | 2022-03-10 | Indiana (54) | 74 | 69 | Michigan (41) | Final | L | -5 |
| 37 | 2022-03-17 | Michigan (45) | 75 | 63 | Colorado State (21) | Final | W | 12 |
| 38 | 2022-03-19 | Michigan (45) | 76 | 68 | Tennessee (5) | Final | W | 8 |
| 39 | 2022-03-24 | Michigan (45) | 55 | 63 | Villanova (7) | Final | L | -8 |