Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-12 | Incarnate Word (280) | 60 | 87 | Baylor (58) | Final | W | 27 |
| 2 | 2021-11-15 | Nicholls State (87) | 60 | 89 | Baylor (109) | Final | W | 29 |
| 3 | 2021-11-17 | Central Arkansas (143) | 47 | 92 | Baylor (58) | Final | W | 45 |
| 4 | 2021-11-20 | Stanford (60) | 48 | 86 | Baylor (58) | Final | W | 38 |
| 5 | 2021-11-24 | Arizona State (61) | 63 | 75 | Baylor (58) | Final | W | 12 |
| 6 | 2021-11-25 | Baylor (58) | 69 | 61 | Virginia Commonwealth (38) | Final | W | 8 |
| 7 | 2021-11-26 | Baylor (58) | 75 | 58 | Michigan State (10) | Final | W | 17 |
| 8 | 2021-12-04 | Arkansas-Pine Bluff (303) | 54 | 99 | Baylor (58) | Final | W | 45 |
| 9 | 2021-12-12 | Villanova (29) | 36 | 57 | Baylor (58) | Final | W | 21 |
| 10 | 2021-12-18 | Baylor (58) | 78 | 70 | Oregon (102) | Final | W | 8 |
| 11 | 2021-12-20 | Alcorn State (348) | 57 | 94 | Baylor (58) | Final | W | 37 |
| 12 | 2021-12-28 | Northwestern State (315) | 68 | 104 | Baylor (58) | Final | W | 36 |
| 13 | 2022-01-01 | Baylor (58) | 77 | 72 | Iowa State (7) | Final | W | 5 |
| 14 | 2022-01-04 | Oklahoma (47) | 74 | 84 | Baylor (58) | Final | W | 10 |
| 15 | 2022-01-08 | Baylor (58) | 76 | 64 | TCU (32) | Final | W | 12 |
| 16 | 2022-01-11 | Texas Tech (20) | 65 | 62 | Baylor (58) | Final | L | -3 |
| 17 | 2022-01-15 | Oklahoma State (57) | 61 | 54 | Baylor (58) | Final | L | -7 |
| 18 | 2022-01-18 | Baylor (58) | 77 | 68 | West Virginia (50) | Final | W | 9 |
| 19 | 2022-01-22 | Baylor (58) | 65 | 51 | Oklahoma (47) | Final | W | 14 |
| 20 | 2022-01-25 | Kansas State (73) | 49 | 74 | Baylor (3) | Final | W | 25 |
| 21 | 2022-01-29 | Baylor (58) | 78 | 87 | Alabama (15) | Final | L | -9 |
| 22 | 2022-01-31 | West Virginia (46) | 77 | 81 | Baylor (3) | Final | W | 4 |
| 23 | 2022-02-05 | Baylor (58) | 59 | 83 | Kansas (19) | Final | L | -24 |
| 24 | 2022-02-09 | Baylor (58) | 75 | 60 | Kansas State (96) | Final | W | 15 |
| 25 | 2022-02-12 | Texas (41) | 63 | 80 | Baylor (58) | Final | W | 17 |
| 26 | 2022-02-16 | Baylor (4) | 73 | 83 | Texas Tech (12) | Final | L | -10 |
| 27 | 2022-02-19 | TCU (36) | 62 | 72 | Baylor (4) | Final | W | 10 |
| 28 | 2022-02-21 | Baylor (5) | 66 | 64 | Oklahoma State (65) | Final | W | 2 |
| 29 | 2022-02-26 | Kansas (4) | 70 | 80 | Baylor (5) | Final | W | 10 |
| 30 | 2022-02-28 | Baylor (3) | 68 | 61 | Texas (19) | Final | W | 7 |
| 31 | 2022-03-05 | Iowa State (29) | 68 | 75 | Baylor (3) | Final | W | 7 |
| 32 | 2022-03-10 | Oklahoma (47) | 72 | 67 | Baylor (3) | Final | L | -5 |
| 33 | 2022-03-17 | Norfolk State (147) | 49 | 85 | Baylor (4) | Final | W | 36 |
| 34 | 2022-03-19 | North Carolina (31) | 93 | 86 | Baylor (4) | Final (OT) | L | -7 |