Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | Western Carolina (246) | 66 | 85 | Charleston (223) | Final | W | 19 |
| 2 | 2021-11-11 | South Carolina State (345) | 74 | 106 | Charleston (223) | Final | W | 32 |
| 3 | 2021-11-12 | Lipscomb (190) | 77 | 86 | Charleston (123) | Final | W | 9 |
| 4 | 2021-11-13 | Loyola-Maryland (183) | 72 | 79 | Charleston (223) | Final | W | 7 |
| 5 | 2021-11-16 | North Carolina (54) | 94 | 83 | Charleston (26) | Final | L | -11 |
| 6 | 2021-11-22 | Charleston (123) | 66 | 96 | Oklahoma State (57) | Final | L | -30 |
| 7 | 2021-11-27 | Charleston (130) | 68 | 66 | Chattanooga (35) | Final | W | 2 |
| 8 | 2021-11-30 | Tulane (254) | 77 | 81 | Charleston (105) | Final | W | 4 |
| 9 | 2021-12-03 | Charleston (123) | 88 | 91 | Furman (157) | Final/OT | L | -3 |
| 10 | 2021-12-07 | Charleston (123) | 86 | 72 | Tulane (167) | Final | W | 14 |
| 11 | 2021-12-12 | Presbyterian (264) | 76 | 78 | Charleston (123) | Final/OT | W | 2 |
| 12 | 2021-12-16 | Charleston (123) | 59 | 67 | Stetson (301) | Final | L | -8 |
| 13 | 2021-12-19 | Charleston (123) | 0 | 0 | Rhode Island (145) | Cancelled | - | - |
| 14 | 2021-12-19 | Rhode Island (76) | 0 | 0 | Charleston (90) | Cancelled | - | - |
| 15 | 2021-12-22 | Charleston (123) | 82 | 80 | Old Dominion (254) | Final | W | 2 |
| 16 | 2021-12-29 | Drexel (215) | 0 | 0 | Charleston (123) | Postponed | - | - |
| 17 | 2021-12-31 | Delaware (287) | 67 | 66 | Charleston (123) | Final | L | -1 |
| 18 | 2022-01-03 | Charleston (123) | 0 | 0 | Northeastern (300) | Postponed | - | - |
| 19 | 2022-01-05 | Charleston (123) | 0 | 0 | Hofstra (98) | Postponed | - | - |
| 20 | 2022-01-09 | Elon (285) | 61 | 65 | Charleston (126) | Final | W | 4 |
| 21 | 2022-01-11 | William & Mary (141) | 0 | 0 | Charleston (123) | Postponed | - | - |
| 22 | 2022-01-17 | UNC-Wilmington (239) | 86 | 78 | Charleston (124) | Final | L | -8 |
| 23 | 2022-01-20 | Charleston (123) | 67 | 74 | Towson (152) | Final | L | -7 |
| 24 | 2022-01-22 | Charleston (123) | 94 | 95 | James Madison (202) | Final | L | -1 |
| 25 | 2022-01-25 | William & Mary (331) | 73 | 74 | Charleston (153) | Final | W | 1 |
| 26 | 2022-01-27 | Hofstra (98) | 76 | 73 | Charleston (123) | Final | L | -3 |
| 27 | 2022-01-29 | Northeastern (300) | 63 | 81 | Charleston (123) | Final | W | 18 |
| 28 | 2022-02-03 | Charleston (123) | 84 | 61 | William & Mary (141) | Final | W | 23 |
| 29 | 2022-02-05 | Charleston (123) | 66 | 64 | Elon (232) | Final | W | 2 |
| 30 | 2022-02-12 | Charleston (123) | 79 | 85 | UNC-Wilmington (90) | Final | L | -6 |
| 31 | 2022-02-14 | Drexel (215) | 75 | 79 | Charleston (123) | Final | W | 4 |
| 32 | 2022-02-17 | James Madison (202) | 71 | 63 | Charleston (123) | Final | L | -8 |
| 33 | 2022-02-19 | Towson (98) | 80 | 77 | Charleston (151) | Final | L | -3 |
| 34 | 2022-02-22 | Charleston (163) | 83 | 72 | Northeastern (261) | Final | W | 11 |
| 35 | 2022-02-24 | Charleston (163) | 99 | 96 | Delaware (116) | Final | W | 3 |
| 36 | 2022-02-26 | Charleston (163) | 79 | 80 | Drexel (165) | Final | L | -1 |
| 37 | 2022-02-28 | Charleston (150) | 84 | 89 | Hofstra (109) | Final | L | -5 |
| 38 | 2022-03-06 | Charleston (148) | 92 | 76 | Hofstra (111) | Final | W | 16 |
| 39 | 2022-03-07 | Charleston (148) | 57 | 60 | UNC-Wilmington (126) | Final | L | -3 |