Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-31 | Morehouse | 52 | 89 | Georgia Tech (36) | Final | W | 37 |
| 2 | 2021-11-09 | Miami (OH) (193) | 72 | 69 | Georgia Tech (36) | Final | L | -3 |
| 3 | 2021-11-12 | Stetson (301) | 52 | 77 | Georgia Tech (158) | Final | W | 25 |
| 4 | 2021-11-15 | Lamar (269) | 66 | 75 | Georgia Tech (148) | Final | W | 9 |
| 5 | 2021-11-19 | Georgia Tech (158) | 88 | 78 | Georgia (35) | Final | W | 10 |
| 6 | 2021-11-22 | Charleston Southern (262) | 70 | 85 | Georgia Tech (158) | Final | W | 15 |
| 7 | 2021-11-26 | Georgia Southern (216) | 59 | 61 | Georgia Tech (158) | Final | W | 2 |
| 8 | 2021-12-01 | Wisconsin (24) | 70 | 66 | Georgia Tech (158) | Final | L | -4 |
| 9 | 2021-12-05 | North Carolina (77) | 79 | 62 | Georgia Tech (89) | Final | L | -17 |
| 10 | 2021-12-11 | LSU (77) | 69 | 53 | Georgia Tech (158) | Final | L | -16 |
| 11 | 2021-12-18 | Georgia Tech (158) | 53 | 67 | USC (71) | Final | L | -14 |
| 12 | 2021-12-21 | Georgia State (299) | 62 | 72 | Georgia Tech (158) | Final/OT | W | 10 |
| 13 | 2021-12-23 | Alabama A&M (286) | 0 | 0 | Georgia Tech (158) | Cancelled | - | - |
| 14 | 2022-01-02 | Louisville (21) | 67 | 64 | Georgia Tech (158) | Final | L | -3 |
| 15 | 2022-01-04 | Georgia Tech (158) | 57 | 69 | Duke (3) | Final | L | -12 |
| 16 | 2022-01-08 | Notre Dame (101) | 72 | 68 | Georgia Tech (158) | Final/OT | L | -4 |
| 17 | 2022-01-12 | Georgia Tech (145) | 81 | 76 | Boston College (182) | Final | W | 5 |
| 18 | 2022-01-15 | Georgia Tech (158) | 65 | 88 | North Carolina (22) | Final | L | -23 |
| 19 | 2022-01-19 | Wake Forest (70) | 80 | 64 | Georgia Tech (158) | Final | L | -16 |
| 20 | 2022-01-23 | Clayton State | 53 | 103 | Georgia Tech (168) | Final | W | 50 |
| 21 | 2022-01-26 | Florida State (50) | 61 | 75 | Georgia Tech (168) | Final | W | 14 |
| 22 | 2022-01-29 | Miami (27) | 73 | 62 | Georgia Tech (158) | Final | L | -11 |
| 23 | 2022-02-02 | Georgia Tech (143) | 66 | 81 | Virginia Tech (85) | Final | L | -15 |
| 24 | 2022-02-05 | Clemson (36) | 64 | 69 | Georgia Tech (158) | Final | W | 5 |
| 25 | 2022-02-09 | Georgia Tech (158) | 70 | 79 | Miami (27) | Final | L | -9 |
| 26 | 2022-02-12 | Georgia Tech (158) | 53 | 63 | Virginia (14) | Final | L | -10 |
| 27 | 2022-02-15 | North Carolina State (152) | 76 | 61 | Georgia Tech (147) | Final | L | -15 |
| 28 | 2022-02-19 | Georgia Tech (147) | 68 | 62 | Pittsburgh (162) | Final | W | 6 |
| 29 | 2022-02-21 | Georgia Tech (152) | 73 | 74 | Syracuse (90) | Final | L | -1 |
| 30 | 2022-02-23 | Virginia Tech (70) | 62 | 58 | Georgia Tech (152) | Final | L | -4 |
| 31 | 2022-02-26 | Georgia Tech (152) | 56 | 90 | Notre Dame (56) | Final | L | -34 |
| 32 | 2022-03-02 | Georgia Tech (167) | 65 | 68 | Clemson (102) | Final | L | -3 |
| 33 | 2022-03-05 | Boston College (165) | 78 | 82 | Georgia Tech (167) | Final | W | 4 |
| 34 | 2022-03-08 | Georgia Tech (165) | 74 | 84 | Louisville (128) | Final | L | -10 |