Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Elon (206) | 61 | 74 | Florida (39) | Final | L | -13 |
| 2 | 2021-11-12 | Randolph College | 62 | 107 | Elon (232) | Final | W | 45 |
| 3 | 2021-11-14 | Bluefield | 72 | 89 | Elon (232) | Final | W | 17 |
| 4 | 2021-11-19 | Ole Miss (79) | 74 | 56 | Elon (232) | Final | L | -18 |
| 5 | 2021-11-19 | Elon (224) | 68 | 87 | West Virginia (47) | Final | L | -19 |
| 6 | 2021-11-21 | Temple (174) | 75 | 58 | Elon (306) | Final | L | -17 |
| 7 | 2021-11-27 | Jacksonville State (212) | 93 | 81 | Elon (306) | Final | L | -12 |
| 8 | 2021-11-30 | Elon (312) | 61 | 74 | UNC-Greensboro (134) | Final | L | -13 |
| 9 | 2021-12-04 | High Point (69) | 83 | 77 | Elon (232) | Final | L | -6 |
| 10 | 2021-12-11 | Elon (232) | 63 | 80 | North Carolina (22) | Final | L | -17 |
| 11 | 2021-12-15 | Winthrop (133) | 61 | 63 | Elon (232) | Final | W | 2 |
| 12 | 2021-12-18 | Elon (232) | 56 | 87 | Duke (3) | Final | L | -31 |
| 13 | 2021-12-18 | Shaw | 0 | 0 | Elon (336) | Cancelled | - | - |
| 14 | 2021-12-21 | Elon (232) | 55 | 81 | Arkansas (16) | Final | L | -26 |
| 15 | 2021-12-29 | Northeastern (300) | 62 | 79 | Elon (232) | Final | W | 17 |
| 16 | 2021-12-31 | Hofstra (98) | 0 | 0 | Elon (232) | Postponed | - | - |
| 17 | 2022-01-09 | Elon (285) | 61 | 65 | Charleston (126) | Final | L | -4 |
| 18 | 2022-01-12 | Elon (285) | 66 | 73 | UNC-Wilmington (260) | Final | L | -7 |
| 19 | 2022-01-15 | Towson (152) | 59 | 54 | Elon (232) | Final | L | -5 |
| 20 | 2022-01-17 | James Madison (99) | 67 | 90 | Elon (291) | Final | W | 23 |
| 21 | 2022-01-20 | Elon (232) | 49 | 77 | Drexel (215) | Final | L | -28 |
| 22 | 2022-01-22 | Elon (232) | 77 | 80 | Delaware (287) | Final | L | -3 |
| 23 | 2022-01-27 | William & Mary (141) | 54 | 61 | Elon (232) | Final | W | 7 |
| 24 | 2022-01-29 | Elon (232) | 61 | 65 | William & Mary (141) | Final | L | -4 |
| 25 | 2022-02-03 | UNC-Wilmington (90) | 65 | 78 | Elon (232) | Final | W | 13 |
| 26 | 2022-02-05 | Charleston (123) | 66 | 64 | Elon (232) | Final | L | -2 |
| 27 | 2022-02-10 | Elon (232) | 70 | 66 | James Madison (202) | Final | W | 4 |
| 28 | 2022-02-12 | Elon (232) | 50 | 86 | Towson (152) | Final | L | -36 |
| 29 | 2022-02-17 | Delaware (287) | 71 | 62 | Elon (232) | Final | L | -9 |
| 30 | 2022-02-19 | Drexel (170) | 71 | 60 | Elon (262) | Final | L | -11 |
| 31 | 2022-02-24 | Elon (273) | 81 | 55 | Hofstra (100) | Final | W | 26 |
| 32 | 2022-02-26 | Elon (273) | 67 | 54 | Northeastern (261) | Final | W | 13 |
| 33 | 2022-03-06 | Elon (253) | 58 | 75 | UNC-Wilmington (126) | Final | L | -17 |