Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Georgia Southwestern | 51 | 77 | Clemson (31) | Final | W | 26 |
| 2 | 2021-11-09 | Presbyterian (328) | 53 | 64 | Clemson (31) | Final | W | 11 |
| 3 | 2021-11-12 | Wofford (221) | 68 | 76 | Clemson (36) | Final | W | 8 |
| 4 | 2021-11-15 | Bryant (160) | 70 | 93 | Clemson (38) | Final | W | 23 |
| 5 | 2021-11-18 | Clemson (38) | 75 | 48 | Temple (136) | Final | W | 27 |
| 6 | 2021-11-19 | St. Bonaventure (146) | 68 | 65 | Clemson (36) | Final | L | -3 |
| 7 | 2021-11-21 | Clemson (49) | 59 | 66 | West Virginia (39) | Final | L | -7 |
| 8 | 2021-11-26 | Charleston Southern (262) | 59 | 91 | Clemson (36) | Final | W | 32 |
| 9 | 2021-11-30 | Clemson (51) | 64 | 74 | Rutgers (189) | Final | L | -10 |
| 10 | 2021-12-04 | Clemson (36) | 75 | 80 | Miami (27) | Final | L | -5 |
| 11 | 2021-12-11 | Drake (217) | 80 | 90 | Clemson (36) | Final/OT | W | 10 |
| 12 | 2021-12-14 | Miami (OH) (40) | 76 | 89 | Clemson (36) | Final | W | 13 |
| 13 | 2021-12-18 | South Carolina (110) | 56 | 70 | Clemson (36) | Final | W | 14 |
| 14 | 2021-12-22 | Clemson (36) | 67 | 50 | Virginia (14) | Final | W | 17 |
| 15 | 2021-12-29 | Duke (3) | 0 | 0 | Clemson (36) | Postponed | - | - |
| 16 | 2022-01-04 | Virginia (14) | 75 | 65 | Clemson (36) | Final | L | -10 |
| 17 | 2022-01-08 | Clemson (36) | 70 | 65 | North Carolina State (44) | Final | W | 5 |
| 18 | 2022-01-12 | Clemson (59) | 56 | 72 | Notre Dame (92) | Final | L | -16 |
| 19 | 2022-01-15 | Boston College (151) | 70 | 68 | Clemson (36) | Final | L | -2 |
| 20 | 2022-01-18 | Clemson (36) | 78 | 91 | Syracuse (84) | Final | L | -13 |
| 21 | 2022-01-22 | Pittsburgh (108) | 48 | 75 | Clemson (36) | Final | W | 27 |
| 22 | 2022-01-25 | Clemson (89) | 69 | 71 | Duke (14) | Final | L | -2 |
| 23 | 2022-02-02 | Florida State (68) | 69 | 75 | Clemson (90) | Final | W | 6 |
| 24 | 2022-02-05 | Clemson (36) | 64 | 69 | Georgia Tech (158) | Final | L | -5 |
| 25 | 2022-02-08 | North Carolina (41) | 79 | 77 | Clemson (98) | Final | L | -2 |
| 26 | 2022-02-10 | Duke (3) | 82 | 64 | Clemson (36) | Final | L | -18 |
| 27 | 2022-02-12 | Notre Dame (101) | 76 | 61 | Clemson (36) | Final | L | -15 |
| 28 | 2022-02-15 | Clemson (102) | 80 | 81 | Florida State (92) | Final | L | -1 |
| 29 | 2022-02-19 | Clemson (102) | 61 | 70 | Louisville (121) | Final | L | -9 |
| 30 | 2022-02-23 | Wake Forest (37) | 69 | 80 | Clemson (111) | Final | W | 11 |
| 31 | 2022-02-26 | Clemson (111) | 70 | 60 | Boston College (191) | Final | W | 10 |
| 32 | 2022-03-02 | Georgia Tech (167) | 65 | 68 | Clemson (102) | Final | W | 3 |
| 33 | 2022-03-05 | Virginia Tech (60) | 59 | 63 | Clemson (102) | Final | W | 4 |
| 34 | 2022-03-08 | North Carolina State (160) | 64 | 70 | Clemson (92) | Final | W | 6 |
| 35 | 2022-03-09 | Clemson (92) | 75 | 76 | Virginia Tech (62) | Final | L | -1 |