Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Appalachian State (157) | 53 | 65 | Iona (134) | Final | L | -12 |
| 2 | 2021-11-12 | East Tennessee State (140) | 67 | 69 | Appalachian State (159) | Final | W | 2 |
| 3 | 2021-11-15 | William Peace | 49 | 98 | Appalachian State (198) | Final | W | 49 |
| 4 | 2021-11-18 | Charlotte (61) | 67 | 66 | Appalachian State (198) | Final | L | -1 |
| 5 | 2021-11-22 | Delaware (287) | 75 | 68 | Appalachian State (159) | Final | L | -7 |
| 6 | 2021-11-23 | Appalachian State (164) | 57 | 45 | Akron (155) | Final | W | 12 |
| 7 | 2021-11-24 | Appalachian State (159) | 63 | 65 | Vermont (225) | Final | L | -2 |
| 8 | 2021-11-29 | Hartford (334) | 59 | 69 | Appalachian State (190) | Final | W | 10 |
| 9 | 2021-12-01 | Boyce | 29 | 90 | Appalachian State (159) | Final | W | 61 |
| 10 | 2021-12-10 | Appalachian State (155) | 65 | 73 | Furman (77) | Final | L | -8 |
| 11 | 2021-12-13 | Erskine | 44 | 69 | Appalachian State (159) | Final | W | 25 |
| 12 | 2021-12-16 | Appalachian State (159) | 67 | 92 | Duke (3) | Final | L | -25 |
| 13 | 2021-12-21 | Appalachian State (159) | 50 | 70 | North Carolina (22) | Final | L | -20 |
| 14 | 2021-12-30 | Louisiana (290) | 71 | 55 | Appalachian State (159) | Final | L | -16 |
| 15 | 2022-01-01 | Louisiana-Monroe (358) | 69 | 77 | Appalachian State (159) | Final | W | 8 |
| 16 | 2022-01-06 | Appalachian State (159) | 72 | 64 | South Alabama (177) | Final | W | 8 |
| 17 | 2022-01-08 | Appalachian State (159) | 53 | 68 | Troy (127) | Final | L | -15 |
| 18 | 2022-01-13 | Coastal Carolina (188) | 60 | 61 | Appalachian State (159) | Final | W | 1 |
| 19 | 2022-01-15 | Appalachian State (159) | 84 | 76 | Coastal Carolina (188) | Final/OT | W | 8 |
| 20 | 2022-01-20 | Appalachian State (159) | 61 | 60 | Georgia State (299) | Final | W | 1 |
| 21 | 2022-01-22 | Appalachian State (159) | 70 | 62 | Georgia Southern (216) | Final | W | 8 |
| 22 | 2022-01-27 | Arkansas State (147) | 54 | 61 | Appalachian State (159) | Final | W | 7 |
| 23 | 2022-01-29 | Little Rock (321) | 57 | 72 | Appalachian State (159) | Final | W | 15 |
| 24 | 2022-02-03 | Appalachian State (159) | 66 | 68 | Texas State (199) | Final | L | -2 |
| 25 | 2022-02-05 | Appalachian State (159) | 70 | 61 | Texas-Arlington (162) | Final | W | 9 |
| 26 | 2022-02-10 | Georgia Southern (216) | 61 | 65 | Appalachian State (159) | Final | W | 4 |
| 27 | 2022-02-12 | Georgia State (299) | 58 | 49 | Appalachian State (159) | Final | L | -9 |
| 28 | 2022-02-17 | Troy (127) | 67 | 61 | Appalachian State (159) | Final | L | -6 |
| 29 | 2022-02-19 | South Alabama (136) | 51 | 69 | Appalachian State (141) | Final | W | 18 |
| 30 | 2022-02-23 | Appalachian State (139) | 78 | 66 | Little Rock (295) | Final | W | 12 |
| 31 | 2022-02-25 | Appalachian State (139) | 60 | 62 | Arkansas State (176) | Final | L | -2 |
| 32 | 2022-03-05 | Georgia Southern (251) | 60 | 73 | Appalachian State (145) | Final | W | 13 |
| 33 | 2022-03-06 | Georgia State (155) | 71 | 66 | Appalachian State (150) | Final | L | -5 |
| 34 | 2022-03-15 | South Carolina Upstate (251) | 80 | 74 | Appalachian State (145) | Final | L | -6 |