Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Johns Hopkins | 49 | 60 | Loyola-Maryland (183) | Final | W | 11 |
| 2 | 2021-11-09 | Loyola-Maryland (183) | 67 | 83 | North Carolina (33) | Final | L | -16 |
| 3 | 2021-11-12 | South Carolina State (355) | 65 | 75 | Loyola-Maryland (325) | Final | W | 10 |
| 4 | 2021-11-13 | Loyola-Maryland (183) | 72 | 79 | Charleston (223) | Final | L | -7 |
| 5 | 2021-11-14 | Loyola-Maryland (325) | 65 | 70 | Lipscomb (190) | Final | L | -5 |
| 6 | 2021-11-17 | Loyola-Maryland (325) | 49 | 71 | Coppin State (360) | Final | L | -22 |
| 7 | 2021-11-24 | Elizabethtown | 42 | 69 | Loyola-Maryland (325) | Final | W | 27 |
| 8 | 2021-11-28 | Loyola-Maryland (286) | 75 | 70 | Fairfield (205) | Final | W | 5 |
| 9 | 2021-12-01 | Chicago State (351) | 64 | 78 | Loyola-Maryland (325) | Final | W | 14 |
| 10 | 2021-12-04 | Mount St Mary's (257) | 55 | 61 | Loyola-Maryland (325) | Final | W | 6 |
| 11 | 2021-12-08 | Loyola-Maryland (226) | 71 | 84 | St. Bonaventure (50) | Final | L | -13 |
| 12 | 2021-12-12 | Hampton (260) | 54 | 67 | Loyola-Maryland (325) | Final | W | 13 |
| 13 | 2021-12-18 | Loyola-Maryland | 0 | 0 | Duke | Cancelled | - | - |
| 14 | 2021-12-21 | Goucher | 0 | 0 | Loyola-Maryland (325) | Cancelled | - | - |
| 15 | 2021-12-28 | Loyola-Maryland | 0 | 0 | Maryland | Cancelled | - | - |
| 16 | 2022-01-01 | Loyola-Maryland (325) | 74 | 77 | Army (339) | Final/OT | L | -3 |
| 17 | 2022-01-04 | Holy Cross (334) | 70 | 79 | Loyola-Maryland (325) | Final | W | 9 |
| 18 | 2022-01-07 | Loyola-Maryland (325) | 66 | 58 | Boston University (267) | Final | W | 8 |
| 19 | 2022-01-10 | Bucknell (316) | 67 | 71 | Loyola-Maryland (233) | Final | W | 4 |
| 20 | 2022-01-13 | Lafayette (323) | 60 | 74 | Loyola-Maryland (325) | Final | W | 14 |
| 21 | 2022-01-16 | Loyola-Maryland (209) | 69 | 57 | Lehigh (319) | Final | W | 12 |
| 22 | 2022-01-19 | Boston University (267) | 67 | 50 | Loyola-Maryland (325) | Final | L | -17 |
| 23 | 2022-01-22 | American (249) | 73 | 78 | Loyola-Maryland (325) | Final | W | 5 |
| 24 | 2022-01-24 | Loyola-Maryland (325) | 52 | 65 | Colgate (239) | Final | L | -13 |
| 25 | 2022-01-30 | Loyola-Maryland (252) | 80 | 82 | Bucknell (335) | Final | L | -2 |
| 26 | 2022-02-02 | Army (240) | 57 | 61 | Loyola-Maryland (252) | Final | W | 4 |
| 27 | 2022-02-05 | Navy (149) | 56 | 55 | Loyola-Maryland (325) | Final | L | -1 |
| 28 | 2022-02-09 | Loyola-Maryland (325) | 64 | 68 | Holy Cross (334) | Final | L | -4 |
| 29 | 2022-02-12 | Colgate (239) | 64 | 56 | Loyola-Maryland (325) | Final | L | -8 |
| 30 | 2022-02-16 | Loyola-Maryland (265) | 68 | 77 | Lafayette (306) | Final | L | -9 |
| 31 | 2022-02-20 | Lehigh (309) | 42 | 69 | Loyola-Maryland (267) | Final | W | 27 |
| 32 | 2022-02-23 | Loyola-Maryland (267) | 50 | 52 | Navy (173) | Final | L | -2 |
| 33 | 2022-02-26 | Loyola-Maryland (267) | 55 | 65 | American (327) | Final | L | -10 |
| 34 | 2022-03-03 | Loyola-Maryland (278) | 64 | 76 | Boston University (208) | Final | L | -12 |