Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-20 | Nova Southeastern | 95 | 106 | Miami (144) | Final | W | 11 |
| 2 | 2021-11-09 | Canisius (202) | 67 | 77 | Miami (144) | Final | W | 10 |
| 3 | 2021-11-13 | Central Florida (100) | 95 | 89 | Miami (144) | Final | L | -6 |
| 4 | 2021-11-16 | Miami (189) | 68 | 66 | Florida Atlantic (279) | Final | W | 2 |
| 5 | 2021-11-21 | Florida A&M (298) | 59 | 86 | Miami (100) | Final | W | 27 |
| 6 | 2021-11-25 | Dayton (66) | 76 | 60 | Miami (27) | Final | L | -16 |
| 7 | 2021-11-26 | Miami (27) | 69 | 63 | North Texas (125) | Final | W | 6 |
| 8 | 2021-11-28 | Miami (156) | 64 | 96 | Alabama (11) | Final | L | -32 |
| 9 | 2021-12-01 | Miami (27) | 63 | 58 | Penn State (129) | Final | W | 5 |
| 10 | 2021-12-04 | Clemson (36) | 75 | 80 | Miami (27) | Final | W | 5 |
| 11 | 2021-12-08 | Lipscomb (214) | 59 | 76 | Miami (101) | Final | W | 17 |
| 12 | 2021-12-12 | Miami (27) | 72 | 66 | Fordham (183) | Final | W | 6 |
| 13 | 2021-12-20 | Stetson (301) | 72 | 82 | Miami (27) | Final | W | 10 |
| 14 | 2021-12-29 | North Carolina State (44) | 83 | 91 | Miami (27) | Final | W | 8 |
| 15 | 2022-01-01 | Wake Forest (70) | 84 | 92 | Miami (27) | Final | W | 8 |
| 16 | 2022-01-05 | Syracuse (84) | 87 | 88 | Miami (27) | Final | W | 1 |
| 17 | 2022-01-08 | Miami (27) | 76 | 74 | Duke (3) | Final | W | 2 |
| 18 | 2022-01-11 | Miami (27) | 64 | 65 | Florida State (64) | Final | L | -1 |
| 19 | 2022-01-18 | North Carolina (22) | 57 | 85 | Miami (27) | Final | W | 28 |
| 20 | 2022-01-22 | Florida State (64) | 61 | 60 | Miami (27) | Final | L | -1 |
| 21 | 2022-01-26 | Miami (48) | 78 | 75 | Virginia Tech (86) | Final | W | 3 |
| 22 | 2022-01-29 | Miami (27) | 73 | 62 | Georgia Tech (158) | Final | W | 11 |
| 23 | 2022-02-02 | Notre Dame (69) | 68 | 64 | Miami (40) | Final | L | -4 |
| 24 | 2022-02-05 | Miami (27) | 58 | 71 | Virginia (14) | Final | L | -13 |
| 25 | 2022-02-09 | Georgia Tech (158) | 70 | 79 | Miami (27) | Final | W | 9 |
| 26 | 2022-02-12 | Miami (27) | 76 | 72 | Wake Forest (70) | Final | W | 4 |
| 27 | 2022-02-16 | Miami (43) | 70 | 63 | Louisville (121) | Final | W | 7 |
| 28 | 2022-02-19 | Virginia (76) | 74 | 71 | Miami (43) | Final | L | -3 |
| 29 | 2022-02-22 | Miami (48) | 85 | 64 | Pittsburgh (151) | Final | W | 21 |
| 30 | 2022-02-26 | Virginia Tech (70) | 71 | 70 | Miami (48) | Final | L | -1 |
| 31 | 2022-03-02 | Miami (52) | 81 | 70 | Boston College (165) | Final | W | 11 |
| 32 | 2022-03-05 | Miami (52) | 75 | 72 | Syracuse (96) | Final | W | 3 |
| 33 | 2022-03-10 | Boston College (183) | 69 | 71 | Miami (48) | Final | W | 2 |
| 34 | 2022-03-11 | Miami (48) | 76 | 80 | Duke (11) | Final | L | -4 |
| 35 | 2022-03-18 | Miami (52) | 68 | 66 | USC (24) | Final | W | 2 |
| 36 | 2022-03-20 | Miami (52) | 79 | 61 | Auburn (6) | Final | W | 18 |
| 37 | 2022-03-25 | Iowa State (39) | 56 | 70 | Miami (52) | Final | W | 14 |
| 38 | 2022-03-27 | Miami (52) | 50 | 76 | Kansas (3) | Final | L | -26 |