Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Winston-Salem | 0 | 0 | Duke (62) | Cancelled | - | - |
| 2 | 2021-11-09 | Kentucky (83) | 71 | 79 | Duke (62) | Final | W | 8 |
| 3 | 2021-11-12 | Army (339) | 56 | 82 | Duke (3) | Final | W | 26 |
| 4 | 2021-11-13 | Campbell (220) | 56 | 67 | Duke (62) | Final | W | 11 |
| 5 | 2021-11-16 | Gardner-Webb (296) | 52 | 92 | Duke (1) | Final | W | 40 |
| 6 | 2021-11-19 | Lafayette (323) | 55 | 88 | Duke (3) | Final | W | 33 |
| 7 | 2021-11-22 | The Citadel (332) | 81 | 107 | Duke (3) | Final | W | 26 |
| 8 | 2021-11-26 | Gonzaga (11) | 81 | 84 | Duke (3) | Final | W | 3 |
| 9 | 2021-11-30 | Duke (1) | 66 | 71 | Ohio State (63) | Final | L | -5 |
| 10 | 2021-12-14 | South Carolina State (355) | 62 | 103 | Duke (3) | Final | W | 41 |
| 11 | 2021-12-16 | Appalachian State (159) | 67 | 92 | Duke (3) | Final | W | 25 |
| 12 | 2021-12-18 | Elon (232) | 56 | 87 | Duke (3) | Final | W | 31 |
| 13 | 2021-12-18 | Cleveland State | 0 | 0 | Duke | Cancelled | - | - |
| 14 | 2021-12-18 | Loyola-Maryland | 0 | 0 | Duke | Cancelled | - | - |
| 15 | 2021-12-22 | Virginia Tech (56) | 65 | 76 | Duke (3) | Final | W | 11 |
| 16 | 2021-12-29 | Duke (3) | 0 | 0 | Clemson (36) | Postponed | - | - |
| 17 | 2022-01-01 | Duke (3) | 0 | 0 | Notre Dame (101) | Postponed | - | - |
| 18 | 2022-01-04 | Georgia Tech (158) | 57 | 69 | Duke (3) | Final | W | 12 |
| 19 | 2022-01-08 | Miami (27) | 76 | 74 | Duke (3) | Final | L | -2 |
| 20 | 2022-01-12 | Duke (16) | 76 | 64 | Wake Forest (38) | Final | W | 12 |
| 21 | 2022-01-15 | North Carolina State (44) | 73 | 88 | Duke (3) | Final | W | 15 |
| 22 | 2022-01-18 | Duke (3) | 78 | 79 | Florida State (64) | Final/OT | L | -1 |
| 23 | 2022-01-22 | Syracuse (84) | 59 | 79 | Duke (3) | Final | W | 20 |
| 24 | 2022-01-25 | Clemson (89) | 69 | 71 | Duke (14) | Final | W | 2 |
| 25 | 2022-01-29 | Duke (3) | 74 | 65 | Louisville (21) | Final | W | 9 |
| 26 | 2022-01-31 | Duke (14) | 57 | 43 | Notre Dame (69) | Final | W | 14 |
| 27 | 2022-02-05 | Duke (3) | 87 | 67 | North Carolina (22) | Final | W | 20 |
| 28 | 2022-02-07 | Virginia (14) | 69 | 68 | Duke (3) | Final | L | -1 |
| 29 | 2022-02-10 | Duke (3) | 82 | 64 | Clemson (36) | Final | W | 18 |
| 30 | 2022-02-12 | Duke (3) | 72 | 61 | Boston College (151) | Final | W | 11 |
| 31 | 2022-02-15 | Wake Forest (35) | 74 | 76 | Duke (10) | Final | W | 2 |
| 32 | 2022-02-19 | Florida State (92) | 70 | 88 | Duke (10) | Final | W | 18 |
| 33 | 2022-02-23 | Duke (10) | 65 | 61 | Virginia (74) | Final | W | 4 |
| 34 | 2022-02-26 | Duke (10) | 97 | 72 | Syracuse (90) | Final | W | 25 |
| 35 | 2022-03-01 | Duke (8) | 86 | 56 | Pittsburgh (154) | Final | W | 30 |
| 36 | 2022-03-05 | North Carolina (39) | 94 | 81 | Duke (8) | Final | L | -13 |
| 37 | 2022-03-10 | Syracuse (101) | 79 | 88 | Duke (11) | Final | W | 9 |
| 38 | 2022-03-11 | Miami (48) | 76 | 80 | Duke (11) | Final | W | 4 |
| 39 | 2022-03-12 | Virginia Tech (62) | 82 | 67 | Duke (11) | Final | L | -15 |
| 40 | 2022-03-18 | Cal State-Fullerton (154) | 61 | 78 | Duke (13) | Final | W | 17 |
| 41 | 2022-03-20 | Michigan State (30) | 76 | 85 | Duke (13) | Final | W | 9 |
| 42 | 2022-03-24 | Texas Tech (12) | 73 | 78 | Duke (13) | Final | W | 5 |
| 43 | 2022-03-26 | Arkansas (18) | 69 | 78 | Duke (13) | Final | W | 9 |
| 44 | 2022-04-02 | North Carolina (31) | 81 | 77 | Duke (13) | Final | L | -4 |