Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Navy (68) | 66 | 58 | Virginia (18) | Final | L | -8 |
| 2 | 2021-11-12 | Radford (255) | 52 | 73 | Virginia (14) | Final | W | 21 |
| 3 | 2021-11-16 | Virginia (193) | 47 | 67 | Houston (6) | Final | L | -20 |
| 4 | 2021-11-19 | Coppin State (360) | 52 | 68 | Virginia (14) | Final | W | 16 |
| 5 | 2021-11-22 | Virginia (14) | 65 | 55 | Georgia (35) | Final | W | 10 |
| 6 | 2021-11-23 | Virginia (199) | 58 | 40 | Providence (24) | Final | W | 18 |
| 7 | 2021-11-26 | Lehigh (276) | 43 | 61 | Virginia (14) | Final | W | 18 |
| 8 | 2021-11-29 | Iowa (17) | 75 | 74 | Virginia (75) | Final | L | -1 |
| 9 | 2021-12-03 | Pittsburgh (108) | 56 | 57 | Virginia (14) | Final | W | 1 |
| 10 | 2021-12-07 | Virginia (14) | 49 | 52 | James Madison (202) | Final | L | -3 |
| 11 | 2021-12-18 | Fairleigh Dickinson (343) | 49 | 82 | Virginia (14) | Final | W | 33 |
| 12 | 2021-12-22 | Clemson (36) | 67 | 50 | Virginia (14) | Final | L | -17 |
| 13 | 2022-01-01 | Virginia (14) | 74 | 69 | Syracuse (84) | Final | W | 5 |
| 14 | 2022-01-04 | Virginia (14) | 75 | 65 | Clemson (36) | Final | W | 10 |
| 15 | 2022-01-08 | Virginia (14) | 58 | 74 | North Carolina (22) | Final | L | -16 |
| 16 | 2022-01-12 | Virginia Tech (66) | 52 | 54 | Virginia (91) | Final | W | 2 |
| 17 | 2022-01-15 | Wake Forest (70) | 63 | 55 | Virginia (14) | Final | L | -8 |
| 18 | 2022-01-19 | Virginia (14) | 66 | 61 | Pittsburgh (108) | Final | W | 5 |
| 19 | 2022-01-22 | Virginia (14) | 63 | 77 | North Carolina State (44) | Final | L | -14 |
| 20 | 2022-01-24 | Louisville (21) | 52 | 64 | Virginia (14) | Final | W | 12 |
| 21 | 2022-01-29 | Virginia (14) | 65 | 69 | Notre Dame (101) | Final | L | -4 |
| 22 | 2022-02-01 | Boston College (167) | 55 | 67 | Virginia (101) | Final | W | 12 |
| 23 | 2022-02-05 | Miami (27) | 58 | 71 | Virginia (14) | Final | W | 13 |
| 24 | 2022-02-07 | Virginia (14) | 69 | 68 | Duke (3) | Final | W | 1 |
| 25 | 2022-02-12 | Georgia Tech (158) | 53 | 63 | Virginia (14) | Final | W | 10 |
| 26 | 2022-02-14 | Virginia (14) | 53 | 62 | Virginia Tech (56) | Final | L | -9 |
| 27 | 2022-02-19 | Virginia (76) | 74 | 71 | Miami (43) | Final | W | 3 |
| 28 | 2022-02-23 | Duke (10) | 65 | 61 | Virginia (74) | Final | L | -4 |
| 29 | 2022-02-26 | Florida State (91) | 64 | 63 | Virginia (74) | Final | L | -1 |
| 30 | 2022-03-05 | Virginia (80) | 71 | 61 | Louisville (121) | Final | W | 10 |
| 31 | 2022-03-09 | Louisville (128) | 50 | 51 | Virginia (77) | Final | W | 1 |
| 32 | 2022-03-10 | Virginia (77) | 43 | 63 | North Carolina (29) | Final | L | -20 |
| 33 | 2022-03-16 | Mississippi State (100) | 57 | 60 | Virginia (14) | Final | W | 3 |
| 34 | 2022-03-20 | Virginia (79) | 71 | 69 | North Texas (56) | Final | W | 2 |
| 35 | 2022-03-22 | St. Bonaventure (61) | 52 | 51 | Virginia (79) | Final | L | -1 |