Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Indianapolis | 64 | 86 | Purdue (22) | Final | W | 22 |
| 2 | 2021-11-09 | Bellarmine (158) | 67 | 96 | Purdue (22) | Final | W | 29 |
| 3 | 2021-11-12 | Indiana State (243) | 67 | 92 | Purdue (8) | Final | W | 25 |
| 4 | 2021-11-16 | Wright State (251) | 52 | 96 | Purdue (27) | Final | W | 44 |
| 5 | 2021-11-20 | Purdue (8) | 93 | 84 | North Carolina (22) | Final | W | 9 |
| 6 | 2021-11-21 | Villanova (57) | 74 | 80 | Purdue (4) | Final | W | 6 |
| 7 | 2021-11-26 | Nebraska-Omaha (272) | 40 | 97 | Purdue (8) | Final | W | 57 |
| 8 | 2021-11-30 | Florida State (34) | 65 | 93 | Purdue (8) | Final | W | 28 |
| 9 | 2021-12-03 | Iowa (28) | 70 | 77 | Purdue (8) | Final | W | 7 |
| 10 | 2021-12-09 | Purdue (2) | 68 | 70 | Rutgers (178) | Final | L | -2 |
| 11 | 2021-12-12 | Purdue (8) | 82 | 72 | North Carolina State (44) | Final/OT | W | 10 |
| 12 | 2021-12-18 | Purdue (8) | 77 | 48 | Butler (80) | Final | W | 29 |
| 13 | 2021-12-20 | Incarnate Word (280) | 59 | 79 | Purdue (8) | Final | W | 20 |
| 14 | 2021-12-29 | Nicholls State (250) | 90 | 104 | Purdue (8) | Final | W | 14 |
| 15 | 2022-01-03 | Wisconsin (24) | 74 | 69 | Purdue (8) | Final | L | -5 |
| 16 | 2022-01-08 | Purdue (8) | 74 | 67 | Penn State (129) | Final | W | 7 |
| 17 | 2022-01-11 | Purdue (8) | 0 | 0 | Michigan (1) | Postponed | - | - |
| 18 | 2022-01-14 | Nebraska (197) | 65 | 92 | Purdue (10) | Final | W | 27 |
| 19 | 2022-01-17 | Purdue (9) | 96 | 88 | Illinois (17) | Final | W | 8 |
| 20 | 2022-01-20 | Purdue (8) | 65 | 68 | Indiana (46) | Final | L | -3 |
| 21 | 2022-01-23 | Northwestern (94) | 60 | 80 | Purdue (10) | Final | W | 20 |
| 22 | 2022-01-27 | Purdue (8) | 83 | 73 | Iowa (28) | Final | W | 10 |
| 23 | 2022-01-30 | Ohio State (22) | 78 | 81 | Purdue (8) | Final | W | 3 |
| 24 | 2022-02-02 | Purdue (8) | 88 | 73 | Minnesota (64) | Final | W | 15 |
| 25 | 2022-02-05 | Michigan (1) | 76 | 82 | Purdue (8) | Final | W | 6 |
| 26 | 2022-02-08 | Illinois (15) | 68 | 84 | Purdue (6) | Final | W | 16 |
| 27 | 2022-02-10 | Purdue (8) | 58 | 82 | Michigan (1) | Final | L | -24 |
| 28 | 2022-02-13 | Maryland (93) | 61 | 62 | Purdue (7) | Final | W | 1 |
| 29 | 2022-02-16 | Purdue (7) | 70 | 64 | Northwestern (80) | Final | W | 6 |
| 30 | 2022-02-20 | Rutgers (69) | 72 | 84 | Purdue (6) | Final | W | 12 |
| 31 | 2022-02-26 | Purdue (6) | 65 | 68 | Michigan State (26) | Final | L | -3 |
| 32 | 2022-03-01 | Purdue (9) | 67 | 70 | Wisconsin (13) | Final | L | -3 |
| 33 | 2022-03-05 | Indiana (44) | 67 | 69 | Purdue (9) | Final | W | 2 |
| 34 | 2022-03-11 | Penn State (100) | 61 | 69 | Purdue (9) | Final | W | 8 |
| 35 | 2022-03-12 | Michigan State (34) | 70 | 75 | Purdue (9) | Final | W | 5 |
| 36 | 2022-03-13 | Iowa (16) | 75 | 66 | Purdue (11) | Final | L | -9 |
| 37 | 2022-03-18 | Yale (129) | 56 | 78 | Purdue (11) | Final | W | 22 |
| 38 | 2022-03-20 | Texas (25) | 71 | 81 | Purdue (11) | Final | W | 10 |
| 39 | 2022-03-25 | Saint Peter's (128) | 67 | 64 | Purdue (11) | Final | L | -3 |