Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-03 | Emporia State | 60 | 86 | Kansas (15) | Final | W | 26 |
| 2 | 2021-11-09 | Kansas (15) | 87 | 74 | Michigan State (55) | Final | W | 13 |
| 3 | 2021-11-12 | Tarleton State (234) | 62 | 88 | Kansas (19) | Final | W | 26 |
| 4 | 2021-11-18 | Stony Brook (233) | 59 | 88 | Kansas (31) | Final | W | 29 |
| 5 | 2021-11-25 | North Texas (125) | 59 | 71 | Kansas (19) | Final | W | 12 |
| 6 | 2021-11-26 | Dayton (66) | 74 | 73 | Kansas (19) | Final | L | -1 |
| 7 | 2021-11-28 | Kansas (28) | 96 | 83 | Iona (53) | Final | W | 13 |
| 8 | 2021-12-03 | Kansas (19) | 95 | 75 | St. John's (12) | Final | W | 20 |
| 9 | 2021-12-07 | UTEP (274) | 52 | 78 | Kansas (19) | Final | W | 26 |
| 10 | 2021-12-11 | Missouri (51) | 65 | 102 | Kansas (19) | Final | W | 37 |
| 11 | 2021-12-18 | Stephen F. Austin (88) | 72 | 80 | Kansas (19) | Final | W | 8 |
| 12 | 2021-12-21 | Kansas (19) | 0 | 0 | Colorado (73) | Cancelled | - | - |
| 13 | 2021-12-29 | Nevada (67) | 61 | 88 | Kansas (19) | Final | W | 27 |
| 14 | 2021-12-29 | Harvard | 0 | 0 | Kansas | Cancelled | - | - |
| 15 | 2022-01-01 | George Mason (86) | 67 | 76 | Kansas (19) | Final | W | 9 |
| 16 | 2022-01-04 | Kansas (19) | 74 | 63 | Oklahoma State (57) | Final | W | 11 |
| 17 | 2022-01-08 | Kansas (19) | 67 | 75 | Texas Tech (20) | Final | L | -8 |
| 18 | 2022-01-11 | Iowa State (7) | 61 | 62 | Kansas (19) | Final | W | 1 |
| 19 | 2022-01-15 | West Virginia (50) | 59 | 85 | Kansas (19) | Final | W | 26 |
| 20 | 2022-01-18 | Kansas (19) | 67 | 64 | Oklahoma (47) | Final | W | 3 |
| 21 | 2022-01-22 | Kansas (19) | 78 | 75 | Kansas State (96) | Final | W | 3 |
| 22 | 2022-01-24 | Texas Tech (20) | 91 | 94 | Kansas (19) | Final/2OT | W | 3 |
| 23 | 2022-01-29 | Kentucky (26) | 80 | 62 | Kansas (19) | Final | L | -18 |
| 24 | 2022-02-01 | Kansas (5) | 70 | 61 | Iowa State (23) | Final | W | 9 |
| 25 | 2022-02-05 | Baylor (58) | 59 | 83 | Kansas (19) | Final | W | 24 |
| 26 | 2022-02-07 | Kansas (19) | 76 | 79 | Texas (41) | Final | L | -3 |
| 27 | 2022-02-12 | Oklahoma (47) | 69 | 71 | Kansas (19) | Final | W | 2 |
| 28 | 2022-02-14 | Oklahoma State (57) | 62 | 76 | Kansas (19) | Final | W | 14 |
| 29 | 2022-02-19 | Kansas (6) | 71 | 58 | West Virginia (50) | Final | W | 13 |
| 30 | 2022-02-22 | Kansas State (67) | 83 | 102 | Kansas (4) | Final | W | 19 |
| 31 | 2022-02-26 | Kansas (4) | 70 | 80 | Baylor (5) | Final | L | -10 |
| 32 | 2022-03-01 | Kansas (5) | 64 | 74 | TCU (38) | Final | L | -10 |
| 33 | 2022-03-03 | TCU (38) | 68 | 72 | Kansas (5) | Final | W | 4 |
| 34 | 2022-03-05 | Texas (19) | 63 | 70 | Kansas (5) | Final | W | 7 |
| 35 | 2022-03-10 | West Virginia (70) | 63 | 87 | Kansas (5) | Final | W | 24 |
| 36 | 2022-03-11 | TCU (37) | 62 | 75 | Kansas (5) | Final | W | 13 |
| 37 | 2022-03-12 | Texas Tech (14) | 65 | 74 | Kansas (5) | Final | W | 9 |
| 38 | 2022-03-17 | Texas Southern (217) | 56 | 83 | Kansas (3) | Final | W | 27 |
| 39 | 2022-03-19 | Creighton (32) | 72 | 79 | Kansas (3) | Final | W | 7 |
| 40 | 2022-03-25 | Providence (14) | 61 | 66 | Kansas (3) | Final | W | 5 |
| 41 | 2022-03-27 | Miami (52) | 50 | 76 | Kansas (3) | Final | W | 26 |
| 42 | 2022-04-02 | Villanova (7) | 65 | 81 | Kansas (3) | Final | W | 16 |
| 43 | 2022-04-04 | North Carolina (31) | 69 | 72 | Kansas (3) | Final | W | 3 |