Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Lenoir Rhyne | 62 | 103 | Tennessee (19) | Final | W | 41 |
| 2 | 2021-11-09 | Tennessee-Martin (321) | 62 | 90 | Tennessee (19) | Final | W | 28 |
| 3 | 2021-11-14 | East Tennessee State (140) | 62 | 94 | Tennessee (18) | Final | W | 32 |
| 4 | 2021-11-20 | Villanova (29) | 71 | 53 | Tennessee (18) | Final | L | -18 |
| 5 | 2021-11-21 | Tennessee (65) | 89 | 72 | North Carolina (103) | Final | W | 17 |
| 6 | 2021-11-26 | Tennessee Tech (310) | 69 | 80 | Tennessee (18) | Final | W | 11 |
| 7 | 2021-11-30 | Presbyterian (126) | 44 | 86 | Tennessee (39) | Final | W | 42 |
| 8 | 2021-12-04 | Tennessee (18) | 69 | 54 | Colorado (73) | Final | W | 15 |
| 9 | 2021-12-07 | Texas Tech (20) | 57 | 52 | Tennessee (18) | Final/OT | L | -5 |
| 10 | 2021-12-11 | UNC-Greensboro (265) | 36 | 76 | Tennessee (18) | Final | W | 40 |
| 11 | 2021-12-14 | South Carolina Upstate (293) | 52 | 96 | Tennessee (18) | Final | W | 44 |
| 12 | 2021-12-18 | Tennessee (18) | 0 | 0 | Memphis (136) | Cancelled | - | - |
| 13 | 2021-12-18 | Memphis (85) | 0 | 0 | Tennessee (27) | Cancelled | - | - |
| 14 | 2021-12-22 | Arizona (2) | 73 | 77 | Tennessee (18) | Final | W | 4 |
| 15 | 2021-12-29 | Tennessee (18) | 68 | 73 | Alabama (15) | Final | L | -5 |
| 16 | 2022-01-05 | Ole Miss (79) | 60 | 66 | Tennessee (18) | Final/OT | W | 6 |
| 17 | 2022-01-08 | Tennessee (18) | 67 | 79 | LSU (77) | Final | L | -12 |
| 18 | 2022-01-11 | South Carolina (110) | 46 | 66 | Tennessee (18) | Final | W | 20 |
| 19 | 2022-01-15 | Tennessee (18) | 79 | 107 | Kentucky (26) | Final | L | -28 |
| 20 | 2022-01-18 | Tennessee (18) | 68 | 60 | Vanderbilt (17) | Final | W | 8 |
| 21 | 2022-01-22 | LSU (77) | 50 | 64 | Tennessee (18) | Final | W | 14 |
| 22 | 2022-01-26 | Florida (43) | 71 | 78 | Tennessee (17) | Final | W | 7 |
| 23 | 2022-01-29 | Tennessee (18) | 51 | 52 | Texas (41) | Final | L | -1 |
| 24 | 2022-02-01 | Texas A&M (47) | 80 | 90 | Tennessee (19) | Final | W | 10 |
| 25 | 2022-02-05 | Tennessee (18) | 81 | 57 | South Carolina (110) | Final | W | 24 |
| 26 | 2022-02-09 | Tennessee (18) | 72 | 63 | Mississippi State (100) | Final | W | 9 |
| 27 | 2022-02-12 | Vanderbilt (17) | 64 | 73 | Tennessee (18) | Final | W | 9 |
| 28 | 2022-02-15 | Kentucky (5) | 63 | 76 | Tennessee (11) | Final | W | 13 |
| 29 | 2022-02-19 | Tennessee (11) | 48 | 58 | Arkansas (28) | Final | L | -10 |
| 30 | 2022-02-22 | Tennessee (14) | 80 | 61 | Missouri (133) | Final | W | 19 |
| 31 | 2022-02-26 | Auburn (3) | 62 | 67 | Tennessee (14) | Final | W | 5 |
| 32 | 2022-03-01 | Tennessee (11) | 75 | 68 | Georgia (215) | Final | W | 7 |
| 33 | 2022-03-05 | Arkansas (17) | 74 | 78 | Tennessee (11) | Final | W | 4 |
| 34 | 2022-03-11 | Mississippi State (64) | 59 | 72 | Tennessee (7) | Final | W | 13 |
| 35 | 2022-03-12 | Kentucky (6) | 62 | 69 | Tennessee (7) | Final | W | 7 |
| 36 | 2022-03-13 | Texas A&M (38) | 50 | 65 | Tennessee (5) | Final | W | 15 |
| 37 | 2022-03-17 | Longwood (119) | 56 | 88 | Tennessee (5) | Final | W | 32 |
| 38 | 2022-03-19 | Michigan (45) | 76 | 68 | Tennessee (5) | Final | L | -8 |