Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Winston-Salem | 0 | 0 | Wake Forest (203) | Cancelled | - | - |
| 2 | 2021-11-10 | William & Mary (265) | 59 | 77 | Wake Forest (203) | Final | W | 18 |
| 3 | 2021-11-12 | Western Carolina (223) | 75 | 87 | Wake Forest (70) | Final | W | 12 |
| 4 | 2021-11-17 | Charleston Southern (262) | 59 | 95 | Wake Forest (70) | Final | W | 36 |
| 5 | 2021-11-20 | North Carolina A&T (294) | 63 | 87 | Wake Forest (70) | Final | W | 24 |
| 6 | 2021-11-23 | Kennesaw State (254) | 61 | 92 | Wake Forest (50) | Final | W | 31 |
| 7 | 2021-11-26 | Oregon State (144) | 77 | 80 | Wake Forest (70) | Final/OT | W | 3 |
| 8 | 2021-11-27 | LSU (9) | 75 | 61 | Wake Forest (50) | Final | L | -14 |
| 9 | 2021-11-30 | Northwestern (64) | 73 | 77 | Wake Forest (56) | Final (OT) | W | 4 |
| 10 | 2021-12-04 | Wake Forest (70) | 80 | 61 | Virginia Tech (56) | Final | W | 19 |
| 11 | 2021-12-11 | South Carolina Upstate (293) | 53 | 79 | Wake Forest (70) | Final | W | 26 |
| 12 | 2021-12-14 | Virginia Military (357) | 70 | 77 | Wake Forest (70) | Final | W | 7 |
| 13 | 2021-12-17 | Wake Forest (70) | 82 | 79 | Charlotte (173) | Final | W | 3 |
| 14 | 2021-12-22 | Boston College (151) | 0 | 0 | Wake Forest (70) | Postponed | - | - |
| 15 | 2021-12-29 | Wake Forest (70) | 69 | 73 | Louisville (21) | Final | L | -4 |
| 16 | 2022-01-01 | Wake Forest (70) | 84 | 92 | Miami (27) | Final | L | -8 |
| 17 | 2022-01-04 | Florida State (64) | 54 | 76 | Wake Forest (70) | Final | W | 22 |
| 18 | 2022-01-08 | Syracuse (84) | 74 | 77 | Wake Forest (70) | Final/OT | W | 3 |
| 19 | 2022-01-12 | Duke (16) | 76 | 64 | Wake Forest (38) | Final | L | -12 |
| 20 | 2022-01-15 | Wake Forest (70) | 63 | 55 | Virginia (14) | Final | W | 8 |
| 21 | 2022-01-19 | Wake Forest (70) | 80 | 64 | Georgia Tech (158) | Final | W | 16 |
| 22 | 2022-01-22 | North Carolina (22) | 76 | 98 | Wake Forest (70) | Final | W | 22 |
| 23 | 2022-01-24 | Boston College (151) | 57 | 87 | Wake Forest (70) | Final | W | 30 |
| 24 | 2022-01-29 | Wake Forest (70) | 72 | 94 | Syracuse (84) | Final | L | -22 |
| 25 | 2022-02-02 | Pittsburgh (179) | 75 | 91 | Wake Forest (39) | Final | W | 16 |
| 26 | 2022-02-05 | Wake Forest (70) | 68 | 60 | Florida State (64) | Final | W | 8 |
| 27 | 2022-02-09 | Wake Forest (70) | 69 | 51 | North Carolina State (44) | Final | W | 18 |
| 28 | 2022-02-12 | Miami (27) | 76 | 72 | Wake Forest (70) | Final | L | -4 |
| 29 | 2022-02-15 | Wake Forest (35) | 74 | 76 | Duke (10) | Final | L | -2 |
| 30 | 2022-02-19 | Notre Dame (52) | 74 | 79 | Wake Forest (35) | Final | W | 5 |
| 31 | 2022-02-23 | Wake Forest (37) | 69 | 80 | Clemson (111) | Final | L | -11 |
| 32 | 2022-02-26 | Louisville (117) | 77 | 99 | Wake Forest (37) | Final | W | 22 |
| 33 | 2022-03-02 | North Carolina State (151) | 76 | 101 | Wake Forest (41) | Final | W | 25 |
| 34 | 2022-03-09 | Boston College (183) | 82 | 77 | Wake Forest (39) | Final | L | -5 |
| 35 | 2022-03-16 | Towson (152) | 64 | 74 | Wake Forest (70) | Final | W | 10 |
| 36 | 2022-03-19 | Virginia Commonwealth (51) | 74 | 80 | Wake Forest (48) | Final | W | 6 |
| 37 | 2022-03-23 | Wake Forest (48) | 52 | 67 | Texas A&M (38) | Final | L | -15 |