Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Elizabeth City State | 68 | 87 | North Carolina State (80) | Final | W | 19 |
| 2 | 2021-11-09 | Bucknell (207) | 70 | 88 | North Carolina State (80) | Final | W | 18 |
| 3 | 2021-11-13 | Colgate (12) | 74 | 77 | North Carolina State (80) | Final | W | 3 |
| 4 | 2021-11-16 | North Carolina State (75) | 79 | 65 | Central Connecticut State (348) | Final | W | 14 |
| 5 | 2021-11-17 | Oklahoma State (57) | 74 | 68 | North Carolina State (44) | Final | L | -6 |
| 6 | 2021-11-21 | Texas Southern (324) | 57 | 65 | North Carolina State (96) | Final | W | 8 |
| 7 | 2021-11-27 | Louisiana Tech (158) | 81 | 90 | North Carolina State (96) | Final | W | 9 |
| 8 | 2021-12-01 | Nebraska (13) | 100 | 104 | North Carolina State (44) | Final/4OT | W | 4 |
| 9 | 2021-12-04 | Louisville (21) | 73 | 68 | North Carolina State (44) | Final | L | -5 |
| 10 | 2021-12-09 | Bethune-Cookman (309) | 48 | 65 | North Carolina State (90) | Final | W | 17 |
| 11 | 2021-12-12 | Purdue (8) | 82 | 72 | North Carolina State (44) | Final/OT | L | -10 |
| 12 | 2021-12-17 | Richmond (166) | 83 | 74 | North Carolina State (44) | Final | L | -9 |
| 13 | 2021-12-21 | Wright State (124) | 84 | 70 | North Carolina State (44) | Final | L | -14 |
| 14 | 2021-12-29 | North Carolina State (44) | 83 | 91 | Miami (27) | Final | L | -8 |
| 15 | 2022-01-01 | Florida State (64) | 83 | 81 | North Carolina State (44) | Final | L | -2 |
| 16 | 2022-01-04 | North Carolina State (44) | 68 | 63 | Virginia Tech (56) | Final | W | 5 |
| 17 | 2022-01-08 | Clemson (36) | 70 | 65 | North Carolina State (44) | Final | L | -5 |
| 18 | 2022-01-12 | North Carolina State (135) | 79 | 63 | Louisville (65) | Final | W | 16 |
| 19 | 2022-01-15 | North Carolina State (44) | 73 | 88 | Duke (3) | Final | L | -15 |
| 20 | 2022-01-19 | Virginia Tech (56) | 62 | 59 | North Carolina State (44) | Final | L | -3 |
| 21 | 2022-01-22 | Virginia (14) | 63 | 77 | North Carolina State (44) | Final | W | 14 |
| 22 | 2022-01-26 | North Carolina State (117) | 65 | 73 | Notre Dame (77) | Final | L | -8 |
| 23 | 2022-01-29 | North Carolina State (44) | 80 | 100 | North Carolina (22) | Final | L | -20 |
| 24 | 2022-02-02 | Syracuse (106) | 89 | 82 | North Carolina State (130) | Final | L | -7 |
| 25 | 2022-02-05 | Notre Dame (101) | 69 | 57 | North Carolina State (44) | Final | L | -12 |
| 26 | 2022-02-09 | Wake Forest (70) | 69 | 51 | North Carolina State (44) | Final | L | -18 |
| 27 | 2022-02-12 | North Carolina State (44) | 69 | 71 | Pittsburgh (108) | Final | L | -2 |
| 28 | 2022-02-15 | North Carolina State (152) | 76 | 61 | Georgia Tech (147) | Final | W | 15 |
| 29 | 2022-02-23 | Boston College (191) | 69 | 61 | North Carolina State (137) | Final | L | -8 |
| 30 | 2022-02-26 | North Carolina (39) | 84 | 74 | North Carolina State (137) | Final | L | -10 |
| 31 | 2022-03-02 | North Carolina State (151) | 76 | 101 | Wake Forest (41) | Final | L | -25 |
| 32 | 2022-03-05 | North Carolina State (151) | 76 | 89 | Florida State (98) | Final | L | -13 |
| 33 | 2022-03-08 | North Carolina State (160) | 64 | 70 | Clemson (92) | Final | L | -6 |