Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Bowie State | 40 | 98 | Marquette (85) | Final | W | 58 |
| 2 | 2021-11-09 | SIU-Edwardsville (314) | 77 | 88 | Marquette (85) | Final | W | 11 |
| 3 | 2021-11-12 | New Hampshire (346) | 70 | 75 | Marquette (106) | Final | W | 5 |
| 4 | 2021-11-15 | Illinois (39) | 66 | 67 | Marquette (78) | Final | W | 1 |
| 5 | 2021-11-18 | Marquette (78) | 78 | 72 | Ole Miss (20) | Final | W | 6 |
| 6 | 2021-11-19 | Marquette (106) | 82 | 71 | West Virginia (50) | Final | W | 11 |
| 7 | 2021-11-21 | St. Bonaventure (2) | 70 | 54 | Marquette (28) | Final | L | -16 |
| 8 | 2021-11-27 | Northern Illinois (257) | 66 | 80 | Marquette (28) | Final | W | 14 |
| 9 | 2021-11-30 | Jackson State (297) | 54 | 83 | Marquette (35) | Final | W | 29 |
| 10 | 2021-12-04 | Marquette (106) | 76 | 89 | Wisconsin (24) | Final | L | -13 |
| 11 | 2021-12-08 | Marquette (41) | 64 | 63 | Kansas State (89) | Final | W | 1 |
| 12 | 2021-12-11 | UCLA (30) | 67 | 56 | Marquette (106) | Final | L | -11 |
| 13 | 2021-12-18 | Marquette (106) | 71 | 80 | Xavier (92) | Final | L | -9 |
| 14 | 2021-12-21 | Connecticut (4) | 78 | 70 | Marquette (106) | Final | L | -8 |
| 15 | 2021-12-29 | Marquette (106) | 0 | 0 | St. John's (12) | Cancelled | - | - |
| 16 | 2022-01-01 | Creighton (78) | 75 | 69 | Marquette (106) | Final/2OT | L | -6 |
| 17 | 2022-01-04 | Providence (82) | 56 | 88 | Marquette (106) | Final | W | 32 |
| 18 | 2022-01-07 | Marquette (106) | 92 | 64 | Georgetown (83) | Final | W | 28 |
| 19 | 2022-01-11 | DePaul (95) | 76 | 87 | Marquette (106) | Final | W | 11 |
| 20 | 2022-01-15 | Seton Hall (53) | 72 | 73 | Marquette (106) | Final | W | 1 |
| 21 | 2022-01-19 | Marquette (106) | 57 | 54 | Villanova (29) | Final | W | 3 |
| 22 | 2022-01-23 | Xavier (20) | 64 | 75 | Marquette (24) | Final | W | 11 |
| 23 | 2022-01-26 | Marquette (24) | 73 | 63 | Seton Hall (30) | Final | W | 10 |
| 24 | 2022-01-30 | Marquette (24) | 63 | 65 | Providence (10) | Final | L | -2 |
| 25 | 2022-02-02 | Villanova (13) | 73 | 83 | Marquette (24) | Final | W | 10 |
| 26 | 2022-02-08 | Marquette (19) | 72 | 80 | Connecticut (23) | Final | L | -8 |
| 27 | 2022-02-12 | Marquette (106) | 79 | 85 | Butler (80) | Final | L | -6 |
| 28 | 2022-02-16 | Georgetown (204) | 66 | 77 | Marquette (29) | Final | W | 11 |
| 29 | 2022-02-20 | Marquette (30) | 82 | 83 | Creighton (41) | Final | L | -1 |
| 30 | 2022-02-26 | Butler (112) | 56 | 64 | Marquette (30) | Final | W | 8 |
| 31 | 2022-03-02 | Marquette (30) | 80 | 91 | DePaul (93) | Final | L | -11 |
| 32 | 2022-03-05 | St. John's (73) | 77 | 85 | Marquette (30) | Final | W | 8 |
| 33 | 2022-03-10 | Marquette (32) | 63 | 74 | Creighton (40) | Final | L | -11 |
| 34 | 2022-03-17 | Marquette (36) | 63 | 95 | North Carolina (31) | Final | L | -32 |