Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Gannon | 0 | 0 | Pittsburgh (109) | Cancelled | - | - |
| 2 | 2021-11-09 | The Citadel (198) | 78 | 63 | Pittsburgh (109) | Final | L | -15 |
| 3 | 2021-11-12 | Pittsburgh (108) | 59 | 74 | West Virginia (50) | Final | L | -15 |
| 4 | 2021-11-16 | UNC-Wilmington (303) | 51 | 59 | Pittsburgh (301) | Final | W | 8 |
| 5 | 2021-11-19 | Towson (152) | 59 | 63 | Pittsburgh (108) | Final | W | 4 |
| 6 | 2021-11-24 | Vanderbilt (17) | 68 | 52 | Pittsburgh (108) | Final | L | -16 |
| 7 | 2021-11-27 | UMBC (238) | 87 | 77 | Pittsburgh (170) | Final | L | -10 |
| 8 | 2021-11-30 | Minnesota (21) | 54 | 53 | Pittsburgh (229) | Final | L | -1 |
| 9 | 2021-12-03 | Pittsburgh (108) | 56 | 57 | Virginia (14) | Final | L | -1 |
| 10 | 2021-12-09 | Colgate (213) | 68 | 71 | Pittsburgh (235) | Final | W | 3 |
| 11 | 2021-12-12 | Monmouth (176) | 56 | 52 | Pittsburgh (108) | Final | L | -4 |
| 12 | 2021-12-18 | St. John's (12) | 57 | 59 | Pittsburgh (108) | Final | W | 2 |
| 13 | 2021-12-18 | Pittsburgh (226) | 59 | 57 | St. John's (59) | Final | W | 2 |
| 14 | 2021-12-21 | Jacksonville (281) | 55 | 64 | Pittsburgh (108) | Final | W | 9 |
| 15 | 2021-12-28 | Notre Dame (101) | 68 | 67 | Pittsburgh (108) | Final | L | -1 |
| 16 | 2022-01-01 | Pittsburgh (108) | 0 | 0 | Virginia Tech (56) | Postponed | - | - |
| 17 | 2022-01-05 | Pittsburgh (108) | 72 | 75 | Louisville (21) | Final | L | -3 |
| 18 | 2022-01-08 | Boston College (151) | 67 | 69 | Pittsburgh (108) | Final | W | 2 |
| 19 | 2022-01-11 | Pittsburgh (108) | 61 | 77 | Syracuse (84) | Final | L | -16 |
| 20 | 2022-01-15 | Louisville (21) | 53 | 65 | Pittsburgh (108) | Final | W | 12 |
| 21 | 2022-01-19 | Virginia (14) | 66 | 61 | Pittsburgh (108) | Final | L | -5 |
| 22 | 2022-01-22 | Pittsburgh (108) | 48 | 75 | Clemson (36) | Final | L | -27 |
| 23 | 2022-01-25 | Syracuse (106) | 53 | 64 | Pittsburgh (181) | Final | W | 11 |
| 24 | 2022-01-30 | Pittsburgh (179) | 56 | 69 | Boston College (167) | Final | L | -13 |
| 25 | 2022-02-02 | Pittsburgh (179) | 75 | 91 | Wake Forest (39) | Final | L | -16 |
| 26 | 2022-02-05 | Virginia Tech (56) | 76 | 71 | Pittsburgh (108) | Final | L | -5 |
| 27 | 2022-02-07 | Pittsburgh (108) | 47 | 74 | Virginia Tech (56) | Final | L | -27 |
| 28 | 2022-02-09 | Pittsburgh (108) | 56 | 51 | Florida State (64) | Final | W | 5 |
| 29 | 2022-02-12 | North Carolina State (44) | 69 | 71 | Pittsburgh (108) | Final | W | 2 |
| 30 | 2022-02-16 | Pittsburgh (162) | 76 | 67 | North Carolina (33) | Final | W | 9 |
| 31 | 2022-02-19 | Georgia Tech (147) | 68 | 62 | Pittsburgh (162) | Final | L | -6 |
| 32 | 2022-02-22 | Miami (48) | 85 | 64 | Pittsburgh (151) | Final | L | -21 |
| 33 | 2022-03-01 | Duke (8) | 86 | 56 | Pittsburgh (154) | Final | L | -30 |
| 34 | 2022-03-05 | Pittsburgh (154) | 54 | 78 | Notre Dame (46) | Final | L | -24 |
| 35 | 2022-03-08 | Boston College (183) | 66 | 46 | Pittsburgh (164) | Final | L | -20 |