Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-28 | Mississippi College | 0 | 0 | Florida State (20) | Cancelled | - | - |
| 2 | 2021-11-10 | Penn | 70 | 105 | Florida State (20) | Final | W | 35 |
| 3 | 2021-11-14 | Florida State (64) | 55 | 71 | Florida (6) | Final | L | -16 |
| 4 | 2021-11-17 | Tulane (167) | 54 | 59 | Florida State (64) | Final | W | 5 |
| 5 | 2021-11-21 | Florida State (68) | 73 | 45 | Loyola Marymount (215) | Final | W | 28 |
| 6 | 2021-11-22 | Florida State (64) | 81 | 58 | Missouri (51) | Final | W | 23 |
| 7 | 2021-11-24 | Boston University (267) | 80 | 81 | Florida State (64) | Final/OT | W | 1 |
| 8 | 2021-11-30 | Florida State (34) | 65 | 93 | Purdue (8) | Final | L | -28 |
| 9 | 2021-12-04 | Syracuse (84) | 63 | 60 | Florida State (64) | Final | L | -3 |
| 10 | 2021-12-12 | Florida State (64) | 65 | 66 | South Carolina (110) | Final | L | -1 |
| 11 | 2021-12-15 | Lipscomb (190) | 60 | 97 | Florida State (64) | Final | W | 37 |
| 12 | 2021-12-18 | Central Florida (43) | 0 | 0 | Florida State (64) | Cancelled | - | - |
| 13 | 2021-12-18 | Florida State | 0 | 0 | Central Florida | Cancelled | - | - |
| 14 | 2021-12-21 | North Florida (345) | 0 | 0 | Florida State (64) | Postponed | - | - |
| 15 | 2021-12-29 | Florida State (64) | 0 | 0 | Boston College (151) | Postponed | - | - |
| 16 | 2022-01-01 | Florida State (64) | 83 | 81 | North Carolina State (44) | Final | W | 2 |
| 17 | 2022-01-04 | Florida State (64) | 54 | 76 | Wake Forest (70) | Final | L | -22 |
| 18 | 2022-01-08 | Louisville (21) | 70 | 79 | Florida State (64) | Final | W | 9 |
| 19 | 2022-01-11 | Miami (27) | 64 | 65 | Florida State (64) | Final | W | 1 |
| 20 | 2022-01-15 | Florida State (64) | 76 | 71 | Syracuse (84) | Final | W | 5 |
| 21 | 2022-01-18 | Duke (3) | 78 | 79 | Florida State (64) | Final/OT | W | 1 |
| 22 | 2022-01-20 | North Florida (345) | 73 | 86 | Florida State (64) | Final | W | 13 |
| 23 | 2022-01-22 | Florida State (64) | 61 | 60 | Miami (27) | Final | W | 1 |
| 24 | 2022-01-26 | Florida State (50) | 61 | 75 | Georgia Tech (168) | Final | L | -14 |
| 25 | 2022-01-29 | Virginia Tech (56) | 85 | 72 | Florida State (64) | Final | L | -13 |
| 26 | 2022-02-02 | Florida State (68) | 69 | 75 | Clemson (90) | Final | L | -6 |
| 27 | 2022-02-05 | Wake Forest (70) | 68 | 60 | Florida State (64) | Final | L | -8 |
| 28 | 2022-02-09 | Pittsburgh (108) | 56 | 51 | Florida State (64) | Final | L | -5 |
| 29 | 2022-02-12 | Florida State (64) | 74 | 94 | North Carolina (22) | Final | L | -20 |
| 30 | 2022-02-15 | Clemson (102) | 80 | 81 | Florida State (92) | Final | W | 1 |
| 31 | 2022-02-19 | Florida State (92) | 70 | 88 | Duke (10) | Final | L | -18 |
| 32 | 2022-02-21 | Florida State (91) | 55 | 71 | Boston College (191) | Final | L | -16 |
| 33 | 2022-02-26 | Florida State (91) | 64 | 63 | Virginia (74) | Final | W | 1 |
| 34 | 2022-03-02 | Notre Dame (46) | 70 | 74 | Florida State (98) | Final | W | 4 |
| 35 | 2022-03-05 | North Carolina State (151) | 76 | 89 | Florida State (98) | Final | W | 13 |
| 36 | 2022-03-09 | Syracuse (101) | 96 | 57 | Florida State (85) | Final | L | -39 |