Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-29 | Nazareth | 37 | 87 | Notre Dame (102) | Final | W | 50 |
| 2 | 2021-11-05 | St. Norbert | 44 | 78 | Notre Dame (102) | Final | W | 34 |
| 3 | 2021-11-13 | Cal State-Northridge (262) | 52 | 68 | Notre Dame (102) | Final | W | 16 |
| 4 | 2021-11-16 | High Point (238) | 61 | 70 | Notre Dame (114) | Final | W | 9 |
| 5 | 2021-11-22 | Saint Mary's (33) | 62 | 59 | Notre Dame (101) | Final | L | -3 |
| 6 | 2021-11-23 | Notre Dame (85) | 90 | 64 | Chaminade | Final | W | 26 |
| 7 | 2021-11-24 | Texas A&M (39) | 73 | 67 | Notre Dame (101) | Final | L | -6 |
| 8 | 2021-11-29 | Notre Dame (142) | 72 | 82 | Illinois (87) | Final | L | -10 |
| 9 | 2021-12-03 | Notre Dame (101) | 57 | 73 | Boston College (151) | Final | L | -16 |
| 10 | 2021-12-11 | Kentucky (26) | 62 | 66 | Notre Dame (101) | Final | W | 4 |
| 11 | 2021-12-18 | Indiana (46) | 64 | 56 | Notre Dame (101) | Final | L | -8 |
| 12 | 2021-12-20 | Western Michigan (304) | 52 | 85 | Notre Dame (101) | Final | W | 33 |
| 13 | 2021-12-22 | Texas A&M-Corpus Christi (208) | 73 | 83 | Notre Dame (101) | Final | W | 10 |
| 14 | 2021-12-28 | Notre Dame (101) | 68 | 67 | Pittsburgh (108) | Final | W | 1 |
| 15 | 2022-01-01 | Duke (3) | 0 | 0 | Notre Dame (101) | Postponed | - | - |
| 16 | 2022-01-05 | North Carolina (22) | 73 | 78 | Notre Dame (101) | Final | W | 5 |
| 17 | 2022-01-08 | Notre Dame (101) | 72 | 68 | Georgia Tech (158) | Final/OT | W | 4 |
| 18 | 2022-01-12 | Clemson (59) | 56 | 72 | Notre Dame (92) | Final | W | 16 |
| 19 | 2022-01-15 | Notre Dame (101) | 73 | 79 | Virginia Tech (56) | Final | L | -6 |
| 20 | 2022-01-17 | Notre Dame (85) | 71 | 68 | Howard (263) | Final | W | 3 |
| 21 | 2022-01-22 | Notre Dame (101) | 82 | 70 | Louisville (21) | Final | W | 12 |
| 22 | 2022-01-26 | North Carolina State (117) | 65 | 73 | Notre Dame (77) | Final | W | 8 |
| 23 | 2022-01-29 | Virginia (14) | 65 | 69 | Notre Dame (101) | Final | W | 4 |
| 24 | 2022-01-31 | Duke (14) | 57 | 43 | Notre Dame (69) | Final | L | -14 |
| 25 | 2022-02-02 | Notre Dame (69) | 68 | 64 | Miami (40) | Final | W | 4 |
| 26 | 2022-02-05 | Notre Dame (101) | 69 | 57 | North Carolina State (44) | Final | W | 12 |
| 27 | 2022-02-09 | Louisville (21) | 57 | 63 | Notre Dame (101) | Final | W | 6 |
| 28 | 2022-02-12 | Notre Dame (101) | 76 | 61 | Clemson (36) | Final | W | 15 |
| 29 | 2022-02-16 | Boston College (180) | 95 | 99 | Notre Dame (52) | Final (OT) | W | 4 |
| 30 | 2022-02-19 | Notre Dame (52) | 74 | 79 | Wake Forest (35) | Final | L | -5 |
| 31 | 2022-02-23 | Syracuse (90) | 69 | 79 | Notre Dame (56) | Final | W | 10 |
| 32 | 2022-02-26 | Georgia Tech (152) | 56 | 90 | Notre Dame (56) | Final | W | 34 |
| 33 | 2022-03-02 | Notre Dame (46) | 70 | 74 | Florida State (98) | Final | L | -4 |
| 34 | 2022-03-05 | Pittsburgh (154) | 54 | 78 | Notre Dame (46) | Final | W | 24 |
| 35 | 2022-03-10 | Virginia Tech (62) | 87 | 80 | Notre Dame (51) | Final | L | -7 |
| 36 | 2022-03-16 | Notre Dame (101) | 89 | 87 | Rutgers (112) | Final/2OT | W | 2 |
| 37 | 2022-03-18 | Notre Dame (57) | 78 | 64 | Alabama (28) | Final | W | 14 |
| 38 | 2022-03-20 | Notre Dame (57) | 53 | 59 | Texas Tech (12) | Final | L | -6 |