Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-27 | Pace | 0 | 0 | Syracuse (45) | Cancelled | - | - |
| 2 | 2021-11-01 | LeMoyne | 50 | 90 | Syracuse (45) | Final | W | 40 |
| 3 | 2021-11-09 | Lafayette (182) | 63 | 97 | Syracuse (45) | Final | W | 34 |
| 4 | 2021-11-14 | Drexel (215) | 60 | 75 | Syracuse (84) | Final | W | 15 |
| 5 | 2021-11-20 | Colgate (239) | 100 | 85 | Syracuse (84) | Final | L | -15 |
| 6 | 2021-11-24 | Virginia Commonwealth (38) | 67 | 55 | Syracuse (84) | Final | L | -12 |
| 7 | 2021-11-25 | Arizona State (61) | 84 | 92 | Syracuse (84) | Final | W | 8 |
| 8 | 2021-11-26 | Syracuse (84) | 68 | 89 | Auburn (37) | Final | L | -21 |
| 9 | 2021-11-30 | Indiana (16) | 110 | 112 | Syracuse (162) | Final (2OT) | W | 2 |
| 10 | 2021-12-04 | Syracuse (84) | 63 | 60 | Florida State (64) | Final | W | 3 |
| 11 | 2021-12-07 | Villanova (29) | 67 | 53 | Syracuse (84) | Final | L | -14 |
| 12 | 2021-12-11 | Syracuse (84) | 75 | 79 | Georgetown (83) | Final | L | -4 |
| 13 | 2021-12-18 | Lehigh (276) | 0 | 0 | Syracuse (84) | Cancelled | - | - |
| 14 | 2021-12-21 | Cornell (187) | 0 | 0 | Syracuse (84) | Postponed | - | - |
| 15 | 2021-12-27 | Brown (295) | 62 | 93 | Syracuse (84) | Final | W | 31 |
| 16 | 2021-12-29 | Cornell (187) | 68 | 80 | Syracuse (84) | Final | W | 12 |
| 17 | 2022-01-01 | Virginia (14) | 74 | 69 | Syracuse (84) | Final | L | -5 |
| 18 | 2022-01-05 | Syracuse (84) | 87 | 88 | Miami (27) | Final | L | -1 |
| 19 | 2022-01-08 | Syracuse (84) | 74 | 77 | Wake Forest (70) | Final/OT | L | -3 |
| 20 | 2022-01-11 | Pittsburgh (108) | 61 | 77 | Syracuse (84) | Final | W | 16 |
| 21 | 2022-01-15 | Florida State (64) | 76 | 71 | Syracuse (84) | Final | L | -5 |
| 22 | 2022-01-18 | Clemson (36) | 78 | 91 | Syracuse (84) | Final | W | 13 |
| 23 | 2022-01-22 | Syracuse (84) | 59 | 79 | Duke (3) | Final | L | -20 |
| 24 | 2022-01-25 | Syracuse (106) | 53 | 64 | Pittsburgh (181) | Final | L | -11 |
| 25 | 2022-01-29 | Wake Forest (70) | 72 | 94 | Syracuse (84) | Final | W | 22 |
| 26 | 2022-02-02 | Syracuse (106) | 89 | 82 | North Carolina State (130) | Final | W | 7 |
| 27 | 2022-02-05 | Louisville (21) | 69 | 92 | Syracuse (84) | Final | W | 23 |
| 28 | 2022-02-08 | Syracuse (97) | 73 | 64 | Boston College (175) | Final | W | 9 |
| 29 | 2022-02-12 | Syracuse (84) | 59 | 71 | Virginia Tech (56) | Final | L | -12 |
| 30 | 2022-02-19 | Boston College (180) | 56 | 76 | Syracuse (96) | Final | W | 20 |
| 31 | 2022-02-21 | Georgia Tech (152) | 73 | 74 | Syracuse (90) | Final | W | 1 |
| 32 | 2022-02-23 | Syracuse (90) | 69 | 79 | Notre Dame (56) | Final | L | -10 |
| 33 | 2022-02-26 | Duke (10) | 97 | 72 | Syracuse (90) | Final | L | -25 |
| 34 | 2022-02-28 | Syracuse (96) | 79 | 88 | North Carolina (39) | Final | L | -9 |
| 35 | 2022-03-05 | Miami (52) | 75 | 72 | Syracuse (96) | Final | L | -3 |
| 36 | 2022-03-09 | Syracuse (101) | 96 | 57 | Florida State (85) | Final | W | 39 |
| 37 | 2022-03-10 | Syracuse (101) | 79 | 88 | Duke (11) | Final | L | -9 |