Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-29 | Kentucky Wesleyan | 72 | 95 | Kentucky (83) | Final | W | 23 |
| 2 | 2021-11-05 | Miles | 71 | 80 | Kentucky (83) | Final | W | 9 |
| 3 | 2021-11-09 | Kentucky (83) | 71 | 79 | Duke (62) | Final | L | -8 |
| 4 | 2021-11-12 | Robert Morris (148) | 60 | 100 | Kentucky (26) | Final | W | 40 |
| 5 | 2021-11-16 | Mount St Mary's (305) | 55 | 80 | Kentucky (129) | Final | W | 25 |
| 6 | 2021-11-19 | Ohio (218) | 59 | 77 | Kentucky (26) | Final | W | 18 |
| 7 | 2021-11-22 | Albany (330) | 61 | 86 | Kentucky (26) | Final | W | 25 |
| 8 | 2021-11-26 | North Florida (345) | 52 | 86 | Kentucky (26) | Final | W | 34 |
| 9 | 2021-11-29 | Central Michigan (325) | 57 | 85 | Kentucky (27) | Final | W | 28 |
| 10 | 2021-12-07 | Southern (259) | 64 | 76 | Kentucky (26) | Final | W | 12 |
| 11 | 2021-12-11 | Kentucky (26) | 62 | 66 | Notre Dame (101) | Final | L | -4 |
| 12 | 2021-12-18 | North Carolina (22) | 69 | 98 | Kentucky (26) | Final | W | 29 |
| 13 | 2021-12-18 | Ohio State | 0 | 0 | Kentucky | Cancelled | - | - |
| 14 | 2021-12-22 | Western Kentucky (154) | 60 | 95 | Kentucky (26) | Final | W | 35 |
| 15 | 2021-12-22 | Louisville (71) | 0 | 0 | Kentucky (40) | Cancelled | - | - |
| 16 | 2021-12-29 | Missouri (51) | 56 | 83 | Kentucky (26) | Final | W | 27 |
| 17 | 2021-12-31 | High Point (69) | 48 | 92 | Kentucky (26) | Final | W | 44 |
| 18 | 2022-01-04 | Kentucky (26) | 60 | 65 | LSU (77) | Final | L | -5 |
| 19 | 2022-01-08 | Georgia (35) | 77 | 92 | Kentucky (26) | Final | W | 15 |
| 20 | 2022-01-11 | Kentucky (26) | 78 | 66 | Vanderbilt (17) | Final | W | 12 |
| 21 | 2022-01-15 | Tennessee (18) | 79 | 107 | Kentucky (26) | Final | W | 28 |
| 22 | 2022-01-19 | Kentucky (26) | 64 | 58 | Texas A&M (39) | Final | W | 6 |
| 23 | 2022-01-22 | Kentucky (26) | 71 | 80 | Auburn (37) | Final | L | -9 |
| 24 | 2022-01-25 | Mississippi State (49) | 74 | 82 | Kentucky (16) | Final (OT) | W | 8 |
| 25 | 2022-01-29 | Kentucky (26) | 80 | 62 | Kansas (19) | Final | W | 18 |
| 26 | 2022-02-02 | Vanderbilt (94) | 70 | 77 | Kentucky (11) | Final | W | 7 |
| 27 | 2022-02-05 | Kentucky (26) | 66 | 55 | Alabama (15) | Final | W | 11 |
| 28 | 2022-02-08 | Kentucky (7) | 86 | 76 | South Carolina (86) | Final | W | 10 |
| 29 | 2022-02-12 | Florida (6) | 57 | 78 | Kentucky (26) | Final | W | 21 |
| 30 | 2022-02-15 | Kentucky (5) | 63 | 76 | Tennessee (11) | Final | L | -13 |
| 31 | 2022-02-19 | Alabama (22) | 81 | 90 | Kentucky (5) | Final | W | 9 |
| 32 | 2022-02-23 | LSU (19) | 66 | 71 | Kentucky (7) | Final | W | 5 |
| 33 | 2022-02-26 | Kentucky (7) | 73 | 75 | Arkansas (20) | Final | L | -2 |
| 34 | 2022-03-01 | Ole Miss (106) | 72 | 83 | Kentucky (6) | Final | W | 11 |
| 35 | 2022-03-05 | Kentucky (6) | 71 | 63 | Florida (51) | Final | W | 8 |
| 36 | 2022-03-11 | Vanderbilt (80) | 71 | 77 | Kentucky (6) | Final | W | 6 |
| 37 | 2022-03-12 | Kentucky (6) | 62 | 69 | Tennessee (7) | Final | L | -7 |
| 38 | 2022-03-17 | Saint Peter's (128) | 85 | 79 | Kentucky (8) | Final (OT) | L | -6 |