Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Maine (311) | 47 | 82 | Virginia Tech (41) | Final | W | 35 |
| 2 | 2021-11-12 | Virginia Tech (56) | 77 | 57 | Navy (149) | Final | W | 20 |
| 3 | 2021-11-15 | Radford (315) | 39 | 65 | Virginia Tech (12) | Final | W | 26 |
| 4 | 2021-11-18 | St. Francis (PA) (287) | 55 | 85 | Virginia Tech (12) | Final | W | 30 |
| 5 | 2021-11-21 | Merrimack (243) | 43 | 72 | Virginia Tech (19) | Final | W | 29 |
| 6 | 2021-11-24 | Memphis (136) | 69 | 61 | Virginia Tech (56) | Final | L | -8 |
| 7 | 2021-11-26 | Xavier (92) | 59 | 58 | Virginia Tech (56) | Final | L | -1 |
| 8 | 2021-12-01 | Virginia Tech (56) | 62 | 58 | Maryland (114) | Final | W | 4 |
| 9 | 2021-12-04 | Wake Forest (70) | 80 | 61 | Virginia Tech (56) | Final | L | -19 |
| 10 | 2021-12-08 | Cornell (94) | 60 | 93 | Virginia Tech (61) | Final | W | 33 |
| 11 | 2021-12-12 | Virginia Tech (56) | 57 | 62 | Dayton (66) | Final | L | -5 |
| 12 | 2021-12-17 | St. Bonaventure (146) | 49 | 86 | Virginia Tech (56) | Final | W | 37 |
| 13 | 2021-12-22 | Virginia Tech (56) | 65 | 76 | Duke (3) | Final | L | -11 |
| 14 | 2021-12-29 | Virginia Tech (56) | 0 | 0 | North Carolina (22) | Postponed | - | - |
| 15 | 2022-01-01 | Pittsburgh (108) | 0 | 0 | Virginia Tech (56) | Postponed | - | - |
| 16 | 2022-01-04 | North Carolina State (44) | 68 | 63 | Virginia Tech (56) | Final | L | -5 |
| 17 | 2022-01-12 | Virginia Tech (66) | 52 | 54 | Virginia (91) | Final | L | -2 |
| 18 | 2022-01-15 | Notre Dame (101) | 73 | 79 | Virginia Tech (56) | Final | W | 6 |
| 19 | 2022-01-19 | Virginia Tech (56) | 62 | 59 | North Carolina State (44) | Final | W | 3 |
| 20 | 2022-01-22 | Virginia Tech (56) | 63 | 68 | Boston College (151) | Final | L | -5 |
| 21 | 2022-01-24 | Virginia Tech (56) | 68 | 78 | North Carolina (22) | Final | L | -10 |
| 22 | 2022-01-26 | Miami (48) | 78 | 75 | Virginia Tech (86) | Final | L | -3 |
| 23 | 2022-01-29 | Virginia Tech (56) | 85 | 72 | Florida State (64) | Final | W | 13 |
| 24 | 2022-02-02 | Georgia Tech (143) | 66 | 81 | Virginia Tech (85) | Final | W | 15 |
| 25 | 2022-02-05 | Virginia Tech (56) | 76 | 71 | Pittsburgh (108) | Final | W | 5 |
| 26 | 2022-02-07 | Pittsburgh (108) | 47 | 74 | Virginia Tech (56) | Final | W | 27 |
| 27 | 2022-02-12 | Syracuse (84) | 59 | 71 | Virginia Tech (56) | Final | W | 12 |
| 28 | 2022-02-14 | Virginia (14) | 53 | 62 | Virginia Tech (56) | Final | W | 9 |
| 29 | 2022-02-19 | North Carolina (33) | 65 | 57 | Virginia Tech (71) | Final | L | -8 |
| 30 | 2022-02-23 | Virginia Tech (70) | 62 | 58 | Georgia Tech (152) | Final | W | 4 |
| 31 | 2022-02-26 | Virginia Tech (70) | 71 | 70 | Miami (48) | Final | W | 1 |
| 32 | 2022-03-01 | Louisville (121) | 43 | 75 | Virginia Tech (60) | Final | W | 32 |
| 33 | 2022-03-05 | Virginia Tech (60) | 59 | 63 | Clemson (102) | Final | L | -4 |
| 34 | 2022-03-09 | Clemson (92) | 75 | 76 | Virginia Tech (62) | Final | W | 1 |
| 35 | 2022-03-10 | Virginia Tech (62) | 87 | 80 | Notre Dame (51) | Final | W | 7 |
| 36 | 2022-03-11 | Virginia Tech (62) | 72 | 59 | North Carolina (29) | Final | W | 13 |
| 37 | 2022-03-12 | Virginia Tech (62) | 82 | 67 | Duke (11) | Final | W | 15 |
| 38 | 2022-03-18 | Virginia Tech (46) | 73 | 81 | Texas (25) | Final | L | -8 |