Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | UNC-Asheville (255) | 77 | 102 | UAB (78) | Final | L | -25 |
| 2 | 2021-11-11 | Brevard | 44 | 101 | UNC-Asheville (255) | Final | W | 57 |
| 3 | 2021-11-14 | UNC-Asheville (244) | 45 | 75 | Chattanooga (291) | Final | L | -30 |
| 4 | 2021-11-18 | Tennessee Tech (234) | 55 | 61 | UNC-Asheville (277) | Final | W | 6 |
| 5 | 2021-11-23 | UNC-Asheville (210) | 53 | 72 | North Carolina (103) | Final | L | -19 |
| 6 | 2021-11-28 | St. Andrews | 36 | 106 | UNC-Asheville (197) | Final | W | 70 |
| 7 | 2021-12-01 | The Citadel (332) | 58 | 65 | UNC-Asheville (244) | Final | W | 7 |
| 8 | 2021-12-04 | North Carolina Central (341) | 66 | 82 | UNC-Asheville (244) | Final | W | 16 |
| 9 | 2021-12-08 | Chattanooga (45) | 78 | 73 | UNC-Asheville (135) | Final | L | -5 |
| 10 | 2021-12-11 | UNC-Asheville (244) | 73 | 72 | Western Carolina (223) | Final | W | 1 |
| 11 | 2021-12-14 | UNC-Asheville (244) | 68 | 79 | Tennessee-Martin (205) | Final | L | -11 |
| 12 | 2021-12-18 | East Tennessee State (140) | 64 | 79 | UNC-Asheville (244) | Final | W | 15 |
| 13 | 2021-12-21 | Milligan | 54 | 114 | UNC-Asheville (244) | Final | W | 60 |
| 14 | 2021-12-29 | UNC-Asheville (244) | 0 | 0 | Indiana (46) | Cancelled | - | - |
| 15 | 2022-01-05 | UNC-Asheville (244) | 60 | 54 | Campbell (191) | Final | W | 6 |
| 16 | 2022-01-08 | Charleston Southern (262) | 59 | 82 | UNC-Asheville (244) | Final | W | 23 |
| 17 | 2022-01-13 | UNC-Asheville (244) | 80 | 86 | Winthrop (133) | Final/OT | L | -6 |
| 18 | 2022-01-15 | South Carolina Upstate (293) | 76 | 73 | UNC-Asheville (244) | Final | L | -3 |
| 19 | 2022-01-19 | North Carolina A&T (294) | 73 | 71 | UNC-Asheville (244) | Final | L | -2 |
| 20 | 2022-01-22 | UNC-Asheville (244) | 78 | 74 | Radford (255) | Final/OT | W | 4 |
| 21 | 2022-01-27 | Gardner-Webb (363) | 61 | 55 | UNC-Asheville (244) | Final | L | -6 |
| 22 | 2022-01-29 | UNC-Asheville (244) | 68 | 67 | Presbyterian (264) | Final | W | 1 |
| 23 | 2022-02-02 | Longwood (136) | 56 | 48 | UNC-Asheville (214) | Final | L | -8 |
| 24 | 2022-02-05 | UNC-Asheville (244) | 83 | 91 | High Point (69) | Final/OT | L | -8 |
| 25 | 2022-02-09 | Hampton (260) | 53 | 69 | UNC-Asheville (244) | Final | W | 16 |
| 26 | 2022-02-12 | UNC-Asheville (244) | 83 | 56 | South Carolina Upstate (293) | Final | W | 27 |
| 27 | 2022-02-16 | UNC-Asheville (214) | 85 | 66 | Charleston Southern (345) | Final | W | 19 |
| 28 | 2022-02-19 | Winthrop (161) | 84 | 79 | UNC-Asheville (214) | Final | L | -5 |
| 29 | 2022-02-23 | UNC-Asheville (221) | 59 | 60 | Gardner-Webb (189) | Final | L | -1 |
| 30 | 2022-02-26 | Presbyterian (263) | 96 | 98 | UNC-Asheville (221) | Final | W | 2 |
| 31 | 2022-03-02 | Charleston Southern (348) | 79 | 78 | UNC-Asheville (219) | Final | L | -1 |
| 32 | 2022-03-19 | Stephen F. Austin (114) | 68 | 80 | UNC-Asheville (228) | Final | W | 12 |
| 33 | 2022-03-21 | Northern Colorado (209) | 87 | 84 | UNC-Asheville (228) | Final | L | -3 |