Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-24 | LeMoyne-Owen | 57 | 105 | Memphis (48) | Final | W | 48 |
| 2 | 2021-10-31 | Lane | 49 | 88 | Memphis (48) | Final | W | 39 |
| 3 | 2021-11-09 | Tennessee Tech (323) | 65 | 89 | Memphis (48) | Final | W | 24 |
| 4 | 2021-11-13 | North Carolina Central (332) | 51 | 90 | Memphis (48) | Final | W | 39 |
| 5 | 2021-11-16 | Saint Louis (14) | 74 | 90 | Memphis (35) | Final | W | 16 |
| 6 | 2021-11-19 | Western Kentucky (154) | 62 | 74 | Memphis (136) | Final | W | 12 |
| 7 | 2021-11-24 | Memphis (136) | 69 | 61 | Virginia Tech (56) | Final | W | 8 |
| 8 | 2021-11-26 | Iowa State (7) | 78 | 59 | Memphis (136) | Final | L | -19 |
| 9 | 2021-12-01 | Memphis (136) | 79 | 82 | Georgia (35) | Final | L | -3 |
| 10 | 2021-12-04 | Memphis (136) | 63 | 67 | Ole Miss (79) | Final | L | -4 |
| 11 | 2021-12-10 | Murray State (65) | 74 | 72 | Memphis (67) | Final | L | -2 |
| 12 | 2021-12-14 | Alabama (15) | 78 | 92 | Memphis (136) | Final | W | 14 |
| 13 | 2021-12-18 | Tennessee (18) | 0 | 0 | Memphis (136) | Cancelled | - | - |
| 14 | 2021-12-18 | Memphis (85) | 0 | 0 | Tennessee (27) | Cancelled | - | - |
| 15 | 2021-12-21 | Alabama State (331) | 0 | 0 | Memphis (136) | Cancelled | - | - |
| 16 | 2021-12-29 | Memphis (136) | 84 | 85 | Tulane (167) | Final | L | -1 |
| 17 | 2022-01-01 | Memphis (136) | 82 | 64 | Wichita State (76) | Final | W | 18 |
| 18 | 2022-01-04 | Tulsa (55) | 64 | 67 | Memphis (136) | Final | W | 3 |
| 19 | 2022-01-09 | Cincinnati (90) | 80 | 87 | Memphis (54) | Final | W | 7 |
| 20 | 2022-01-12 | Memphis (54) | 64 | 74 | Central Florida (61) | Final | L | -10 |
| 21 | 2022-01-15 | Memphis (136) | 71 | 72 | East Carolina (252) | Final | L | -1 |
| 22 | 2022-01-20 | SMU (45) | 70 | 62 | Memphis (136) | Final | L | -8 |
| 23 | 2022-01-23 | Memphis (82) | 83 | 81 | Tulsa (191) | Final | W | 2 |
| 24 | 2022-01-27 | East Carolina (252) | 54 | 71 | Memphis (136) | Final | W | 17 |
| 25 | 2022-02-03 | Memphis (136) | 0 | 0 | Cincinnati (54) | Postponed | - | - |
| 26 | 2022-02-05 | Central Florida (43) | 60 | 88 | Memphis (136) | Final | W | 28 |
| 27 | 2022-02-09 | Tulane (167) | 69 | 80 | Memphis (136) | Final | W | 11 |
| 28 | 2022-02-12 | Memphis (136) | 69 | 59 | Houston (5) | Final | W | 10 |
| 29 | 2022-02-15 | Memphis (55) | 81 | 74 | Cincinnati (90) | Final | W | 7 |
| 30 | 2022-02-20 | Memphis (55) | 57 | 73 | SMU (43) | Final | L | -16 |
| 31 | 2022-02-24 | Temple (97) | 64 | 78 | Memphis (55) | Final | W | 14 |
| 32 | 2022-02-27 | Wichita State (100) | 57 | 81 | Memphis (47) | Final | W | 24 |
| 33 | 2022-03-03 | Memphis (47) | 73 | 64 | South Florida (233) | Final | W | 9 |
| 34 | 2022-03-06 | Houston (12) | 61 | 75 | Memphis (43) | Final | W | 14 |
| 35 | 2022-03-11 | Central Florida (88) | 69 | 85 | Memphis (43) | Final | W | 16 |
| 36 | 2022-03-12 | Memphis (43) | 70 | 63 | SMU (45) | Final | W | 7 |
| 37 | 2022-03-13 | Memphis (40) | 53 | 71 | Houston (9) | Final | L | -18 |
| 38 | 2022-03-17 | Memphis (40) | 64 | 53 | Boise State (26) | Final | W | 11 |
| 39 | 2022-03-19 | Memphis (40) | 78 | 82 | Gonzaga (2) | Final | L | -4 |