Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Emerson | 48 | 77 | Merrimack (217) | Final | W | 29 |
| 2 | 2021-11-11 | Merrimack (217) | 61 | 54 | NJIT (274) | Final | W | 7 |
| 3 | 2021-11-13 | Merrimack (217) | 35 | 48 | Rutgers (35) | Final | L | -13 |
| 4 | 2021-11-17 | Merrimack (134) | 51 | 74 | Army (339) | Final | L | -23 |
| 5 | 2021-11-19 | Lehigh (276) | 45 | 55 | Merrimack (134) | Final | W | 10 |
| 6 | 2021-11-21 | Merrimack (243) | 43 | 72 | Virginia Tech (19) | Final | L | -29 |
| 7 | 2021-11-23 | Hartford (320) | 60 | 75 | Merrimack (243) | Final | W | 15 |
| 8 | 2021-11-28 | Merrimack (251) | 60 | 61 | Boston University (167) | Final | L | -1 |
| 9 | 2021-12-04 | UMass-Lowell (319) | 61 | 57 | Merrimack (134) | Final | L | -4 |
| 10 | 2021-12-07 | Brown (295) | 76 | 56 | Merrimack (134) | Final | L | -20 |
| 11 | 2021-12-09 | Merrimack (271) | 55 | 80 | Gonzaga (22) | Final | L | -25 |
| 12 | 2021-12-12 | Merrimack (134) | 49 | 81 | Indiana (46) | Final | L | -32 |
| 13 | 2021-12-21 | Merrimack (134) | 49 | 47 | Maine (350) | Final | W | 2 |
| 14 | 2021-12-29 | St. Francis (NY) | 64 | 74 | Merrimack (134) | Final | W | 10 |
| 15 | 2021-12-31 | Long Island (175) | 77 | 82 | Merrimack (134) | Final | W | 5 |
| 16 | 2022-01-06 | Merrimack (134) | 2 | 0 | Fairleigh Dickinson (343) | Forfeit | W | 2 |
| 17 | 2022-01-08 | Merrimack (134) | 66 | 57 | Central Connecticut State (258) | Final | W | 9 |
| 18 | 2022-01-15 | St. Francis (PA) (336) | 62 | 46 | Merrimack (265) | Final | L | -16 |
| 19 | 2022-01-17 | Mount St Mary's (299) | 57 | 50 | Merrimack (287) | Final | L | -7 |
| 20 | 2022-01-21 | Bryant (236) | 79 | 63 | Merrimack (287) | Final | L | -16 |
| 21 | 2022-01-23 | Wagner (72) | 71 | 57 | Merrimack (295) | Final | L | -14 |
| 22 | 2022-01-27 | Merrimack (134) | 67 | 76 | Bryant (349) | Final | L | -9 |
| 23 | 2022-01-29 | Merrimack (134) | 0 | 0 | Sacred Heart (270) | Postponed | - | - |
| 24 | 2022-02-03 | Merrimack (134) | 53 | 69 | Mount St Mary's (257) | Final | L | -16 |
| 25 | 2022-02-05 | Merrimack (134) | 65 | 64 | Saint Francis (354) | Final/OT | W | 1 |
| 26 | 2022-02-05 | Merrimack (293) | 65 | 64 | St. Francis (PA) (320) | Final (OT) | W | 1 |
| 27 | 2022-02-10 | Central Connecticut State (258) | 60 | 57 | Merrimack (134) | Final | L | -3 |
| 28 | 2022-02-12 | Merrimack (134) | 80 | 65 | Wagner (316) | Final/OT | W | 15 |
| 29 | 2022-02-15 | Merrimack (284) | 70 | 63 | Sacred Heart (326) | Final | W | 7 |
| 30 | 2022-02-17 | Fairleigh Dickinson (343) | 44 | 64 | Merrimack (134) | Final | W | 20 |
| 31 | 2022-02-19 | Sacred Heart (326) | 79 | 80 | Merrimack (284) | Final | W | 1 |
| 32 | 2022-02-24 | Merrimack (279) | 74 | 85 | Long Island (257) | Final | L | -11 |
| 33 | 2022-02-26 | Merrimack (279) | 72 | 52 | St. Francis (NY) (315) | Final | W | 20 |