Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Fayetteville State | 40 | 89 | Maryland (40) | Final | W | 49 |
| 2 | 2021-11-09 | Quinnipiac (249) | 69 | 83 | Maryland (40) | Final | W | 14 |
| 3 | 2021-11-11 | George Washington (260) | 64 | 71 | Maryland (40) | Final | W | 7 |
| 4 | 2021-11-13 | Vermont (137) | 57 | 68 | Maryland (40) | Final | W | 11 |
| 5 | 2021-11-17 | George Mason (86) | 71 | 66 | Maryland (114) | Final | L | -5 |
| 6 | 2021-11-19 | Hofstra (98) | 67 | 69 | Maryland (114) | Final | W | 2 |
| 7 | 2021-11-25 | Richmond (166) | 80 | 86 | Maryland (114) | Final | W | 6 |
| 8 | 2021-11-27 | Louisville (120) | 63 | 55 | Maryland (61) | Final | L | -8 |
| 9 | 2021-12-01 | Virginia Tech (56) | 62 | 58 | Maryland (114) | Final | L | -4 |
| 10 | 2021-12-05 | Northwestern (64) | 67 | 61 | Maryland (95) | Final | L | -6 |
| 11 | 2021-12-12 | Florida (6) | 68 | 70 | Maryland (114) | Final | W | 2 |
| 12 | 2021-12-28 | Lehigh (276) | 55 | 76 | Maryland (114) | Final | W | 21 |
| 13 | 2021-12-28 | Loyola-Maryland | 0 | 0 | Maryland | Cancelled | - | - |
| 14 | 2021-12-30 | Brown (295) | 67 | 81 | Maryland (114) | Final | W | 14 |
| 15 | 2022-01-03 | Maryland (114) | 75 | 80 | Iowa (28) | Final | L | -5 |
| 16 | 2022-01-06 | Maryland (114) | 64 | 76 | Illinois (9) | Final | L | -12 |
| 17 | 2022-01-09 | Wisconsin (9) | 70 | 69 | Maryland (98) | Final | L | -1 |
| 18 | 2022-01-12 | Maryland (98) | 94 | 87 | Northwestern (88) | Final (2OT) | W | 7 |
| 19 | 2022-01-15 | Rutgers (112) | 70 | 59 | Maryland (114) | Final | L | -11 |
| 20 | 2022-01-18 | Maryland (114) | 64 | 83 | Michigan (1) | Final | L | -19 |
| 21 | 2022-01-21 | Illinois (17) | 65 | 81 | Maryland (100) | Final | W | 16 |
| 22 | 2022-01-25 | Maryland (93) | 68 | 60 | Rutgers (97) | Final | W | 8 |
| 23 | 2022-01-29 | Indiana (46) | 68 | 55 | Maryland (114) | Final | L | -13 |
| 24 | 2022-02-01 | Michigan State (15) | 65 | 63 | Maryland (89) | Final | L | -2 |
| 25 | 2022-02-06 | Maryland (114) | 67 | 82 | Ohio State (34) | Final | L | -15 |
| 26 | 2022-02-10 | Iowa (28) | 110 | 87 | Maryland (114) | Final | L | -23 |
| 27 | 2022-02-13 | Maryland (93) | 61 | 62 | Purdue (7) | Final | L | -1 |
| 28 | 2022-02-18 | Maryland (93) | 90 | 74 | Nebraska (188) | Final | W | 16 |
| 29 | 2022-02-21 | Penn State (80) | 61 | 67 | Maryland (93) | Final | W | 6 |
| 30 | 2022-02-24 | Maryland (93) | 64 | 74 | Indiana (45) | Final | L | -10 |
| 31 | 2022-02-27 | Ohio State (27) | 60 | 75 | Maryland (82) | Final | W | 15 |
| 32 | 2022-03-02 | Minnesota (89) | 73 | 84 | Maryland (82) | Final | W | 11 |
| 33 | 2022-03-06 | Maryland (81) | 67 | 77 | Michigan State (34) | Final | L | -10 |
| 34 | 2022-03-10 | Maryland (81) | 72 | 76 | Michigan State (34) | Final | L | -4 |