Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Cornell | 76 | 69 | Binghamton (300) | Final | W | 7 |
| 2 | 2021-11-12 | Cornell (187) | 90 | 85 | Lafayette (323) | Final | W | 5 |
| 3 | 2021-11-16 | Colgate (175) | 68 | 78 | Cornell (73) | Final | W | 10 |
| 4 | 2021-11-19 | Wells | 48 | 107 | Cornell (73) | Final | W | 59 |
| 5 | 2021-11-22 | Cornell (187) | 74 | 85 | Penn State (129) | Final | L | -11 |
| 6 | 2021-11-24 | St. Francis (PA) (291) | 80 | 93 | Cornell (58) | Final | W | 13 |
| 7 | 2021-11-29 | Cornell (92) | 89 | 75 | Canisius (269) | Final | W | 14 |
| 8 | 2021-12-03 | Coppin State (360) | 77 | 92 | Cornell (187) | Final | W | 15 |
| 9 | 2021-12-05 | Keuka | 64 | 122 | Cornell (92) | Final | W | 58 |
| 10 | 2021-12-08 | Cornell (94) | 60 | 93 | Virginia Tech (61) | Final | L | -33 |
| 11 | 2021-12-19 | Bryant (349) | 0 | 0 | Cornell (187) | Cancelled | - | - |
| 12 | 2021-12-21 | Cornell (187) | 0 | 0 | Syracuse (84) | Postponed | - | - |
| 13 | 2021-12-28 | Hartford | 0 | 0 | Cornell (187) | Cancelled | - | - |
| 14 | 2021-12-29 | Cornell (187) | 68 | 80 | Syracuse (84) | Final | L | -12 |
| 15 | 2022-01-02 | Dartmouth (256) | 71 | 79 | Cornell (187) | Final | W | 8 |
| 16 | 2022-01-07 | Cornell (187) | 65 | 79 | Penn (131) | Final | L | -14 |
| 17 | 2022-01-08 | Cornell (187) | 70 | 72 | Princeton (271) | Final | L | -2 |
| 18 | 2022-01-15 | Cornell (187) | 69 | 96 | Yale (81) | Final | L | -27 |
| 19 | 2022-01-22 | Harvard (181) | 61 | 76 | Cornell (187) | Final | W | 15 |
| 20 | 2022-01-30 | Cornell (174) | 74 | 72 | Brown (221) | Final | W | 2 |
| 21 | 2022-02-04 | Princeton (107) | 83 | 88 | Cornell (174) | Final | W | 5 |
| 22 | 2022-02-05 | Penn (131) | 73 | 68 | Cornell (187) | Final | L | -5 |
| 23 | 2022-02-09 | Columbia (193) | 75 | 88 | Cornell (187) | Final | W | 13 |
| 24 | 2022-02-12 | Brown (295) | 81 | 80 | Cornell (187) | Final | L | -1 |
| 25 | 2022-02-18 | Cornell (169) | 59 | 71 | Dartmouth (293) | Final | L | -12 |
| 26 | 2022-02-19 | Cornell (169) | 72 | 77 | Harvard (236) | Final (OT) | L | -5 |
| 27 | 2022-02-26 | Yale (134) | 65 | 71 | Cornell (198) | Final | W | 6 |
| 28 | 2022-03-05 | Cornell (188) | 78 | 64 | Columbia (350) | Final | W | 14 |
| 29 | 2022-03-12 | Cornell (190) | 73 | 77 | Princeton (96) | Final | L | -4 |