Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | St. Francis (PA) (270) | 72 | 75 | George Washington (260) | Final | L | -3 |
| 2 | 2021-11-15 | Franciscan | 54 | 100 | St. Francis (PA) (287) | Final | W | 46 |
| 3 | 2021-11-18 | St. Francis (PA) (287) | 55 | 85 | Virginia Tech (12) | Final | L | -30 |
| 4 | 2021-11-24 | St. Francis (PA) (291) | 80 | 93 | Cornell (58) | Final | L | -13 |
| 5 | 2021-11-28 | St. Francis (PA) (274) | 79 | 68 | Lehigh (333) | Final | W | 11 |
| 6 | 2021-12-01 | Bucknell (311) | 67 | 93 | St. Francis (PA) (274) | Final | W | 26 |
| 7 | 2021-12-04 | St. Francis (PA) (274) | 75 | 78 | Ohio (72) | Final | L | -3 |
| 8 | 2021-12-08 | St. Francis (PA) (258) | 73 | 83 | American (340) | Final | L | -10 |
| 9 | 2021-12-14 | St. Francis (PA) (286) | 81 | 66 | Hartford (331) | Final | W | 15 |
| 10 | 2021-12-18 | St. Francis (PA) (286) | 48 | 106 | Illinois (43) | Final | L | -58 |
| 11 | 2021-12-22 | Robert Morris (347) | 75 | 67 | St. Francis (PA) (282) | Final | L | -8 |
| 12 | 2021-12-29 | Wagner (74) | 72 | 64 | St. Francis (PA) (301) | Final | L | -8 |
| 13 | 2021-12-31 | Fairleigh Dickinson (352) | 0 | 0 | St. Francis (PA) (301) | Cancelled | - | - |
| 14 | 2022-01-06 | St. Francis (PA) (321) | 53 | 70 | St. Francis (NY) (345) | Final | L | -17 |
| 15 | 2022-01-08 | St. Francis (PA) (321) | 70 | 75 | Long Island (306) | Final (OT) | L | -5 |
| 16 | 2022-01-15 | St. Francis (PA) (336) | 62 | 46 | Merrimack (265) | Final | W | 16 |
| 17 | 2022-01-17 | St. Francis (PA) (325) | 52 | 82 | Bryant (236) | Final | L | -30 |
| 18 | 2022-01-21 | Central Connecticut State (332) | 67 | 68 | St. Francis (PA) (325) | Final | W | 1 |
| 19 | 2022-01-23 | Sacred Heart (312) | 74 | 85 | St. Francis (PA) (317) | Final | W | 11 |
| 20 | 2022-01-27 | St. Francis (PA) (317) | 54 | 69 | Wagner (72) | Final | L | -15 |
| 21 | 2022-01-29 | St. Francis (PA) (320) | 54 | 71 | Mount St Mary's (260) | Final | L | -17 |
| 22 | 2022-02-03 | Bryant (196) | 89 | 82 | St. Francis (PA) (320) | Final | L | -7 |
| 23 | 2022-02-05 | Merrimack (293) | 65 | 64 | St. Francis (PA) (320) | Final (OT) | L | -1 |
| 24 | 2022-02-10 | St. Francis (PA) (326) | 78 | 65 | Fairleigh Dickinson (353) | Final | W | 13 |
| 25 | 2022-02-12 | Mount St Mary's (258) | 54 | 52 | St. Francis (PA) (326) | Final | L | -2 |
| 26 | 2022-02-17 | Long Island (272) | 81 | 63 | St. Francis (PA) (323) | Final | L | -18 |
| 27 | 2022-02-19 | St. Francis (NY) (324) | 80 | 72 | St. Francis (PA) (323) | Final | L | -8 |
| 28 | 2022-02-24 | St. Francis (PA) (335) | 79 | 63 | Central Connecticut State (345) | Final | W | 16 |
| 29 | 2022-02-26 | St. Francis (PA) (335) | 68 | 80 | Sacred Heart (336) | Final | L | -12 |
| 30 | 2022-03-02 | St. Francis (PA) (334) | 53 | 82 | Wagner (123) | Final | L | -29 |