Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Alfred State | 54 | 95 | St. Bonaventure (29) | Final | W | 41 |
| 2 | 2021-11-09 | Siena (142) | 47 | 75 | St. Bonaventure (29) | Final | W | 28 |
| 3 | 2021-11-14 | Canisius (328) | 60 | 69 | St. Bonaventure (146) | Final | W | 9 |
| 4 | 2021-11-18 | St. Bonaventure (95) | 67 | 61 | Boise State (184) | Final | W | 6 |
| 5 | 2021-11-19 | St. Bonaventure (146) | 68 | 65 | Clemson (36) | Final | W | 3 |
| 6 | 2021-11-21 | St. Bonaventure (2) | 70 | 54 | Marquette (28) | Final | W | 16 |
| 7 | 2021-11-27 | Northern Iowa (299) | 90 | 80 | St. Bonaventure (2) | Final | L | -10 |
| 8 | 2021-12-01 | Coppin State (360) | 81 | 93 | St. Bonaventure (146) | Final | W | 12 |
| 9 | 2021-12-04 | Buffalo (219) | 65 | 68 | St. Bonaventure (146) | Final | W | 3 |
| 10 | 2021-12-08 | Loyola-Maryland (226) | 71 | 84 | St. Bonaventure (50) | Final | W | 13 |
| 11 | 2021-12-11 | St. Bonaventure (146) | 64 | 74 | Connecticut (4) | Final | L | -10 |
| 12 | 2021-12-17 | St. Bonaventure (146) | 49 | 86 | Virginia Tech (56) | Final | L | -37 |
| 13 | 2021-12-22 | St. Bonaventure (146) | 0 | 0 | Northeastern (300) | Cancelled | - | - |
| 14 | 2021-12-30 | St. Bonaventure (146) | 0 | 0 | George Washington (104) | Cancelled | - | - |
| 15 | 2022-01-02 | St. Bonaventure (146) | 0 | 0 | Dayton (66) | Postponed | - | - |
| 16 | 2022-01-05 | Fordham (183) | 0 | 0 | St. Bonaventure (146) | Postponed | - | - |
| 17 | 2022-01-11 | St. Bonaventure (146) | 80 | 76 | La Salle (237) | Final/OT | W | 4 |
| 18 | 2022-01-14 | Virginia Commonwealth (60) | 53 | 73 | St. Bonaventure (74) | Final | W | 20 |
| 19 | 2022-01-18 | St. Bonaventure (146) | 50 | 68 | Dayton (66) | Final | L | -18 |
| 20 | 2022-01-21 | St. Bonaventure (57) | 64 | 56 | Duquesne (222) | Final | W | 8 |
| 21 | 2022-01-26 | St. Bonaventure (69) | 66 | 75 | George Mason (127) | Final | L | -9 |
| 22 | 2022-01-29 | Saint Joseph's (99) | 69 | 80 | St. Bonaventure (146) | Final | W | 11 |
| 23 | 2022-02-01 | Davidson (35) | 81 | 76 | St. Bonaventure (72) | Final | L | -5 |
| 24 | 2022-02-04 | St. Bonaventure (72) | 61 | 71 | Richmond (95) | Final | L | -10 |
| 25 | 2022-02-08 | Fordham (184) | 51 | 76 | St. Bonaventure (91) | Final | W | 25 |
| 26 | 2022-02-11 | St. Bonaventure (146) | 68 | 61 | Saint Louis (31) | Final | W | 7 |
| 27 | 2022-02-14 | Saint Louis (31) | 79 | 83 | St. Bonaventure (146) | Final | W | 4 |
| 28 | 2022-02-16 | Massachusetts (166) | 71 | 83 | St. Bonaventure (77) | Final | W | 12 |
| 29 | 2022-02-19 | Duquesne (259) | 55 | 81 | St. Bonaventure (77) | Final | W | 26 |
| 30 | 2022-02-22 | Rhode Island (144) | 55 | 73 | St. Bonaventure (58) | Final | W | 18 |
| 31 | 2022-02-26 | St. Bonaventure (58) | 54 | 52 | Saint Joseph's (177) | Final | W | 2 |
| 32 | 2022-03-01 | St. Bonaventure (54) | 51 | 74 | Virginia Commonwealth (43) | Final | L | -23 |
| 33 | 2022-03-04 | Richmond (83) | 65 | 72 | St. Bonaventure (54) | Final | W | 7 |
| 34 | 2022-03-11 | Saint Louis (56) | 57 | 56 | St. Bonaventure (57) | Final | L | -1 |
| 35 | 2022-03-15 | St. Bonaventure (61) | 76 | 68 | Colorado (55) | Final | W | 8 |
| 36 | 2022-03-20 | St. Bonaventure (61) | 70 | 68 | Oklahoma (44) | Final | W | 2 |
| 37 | 2022-03-22 | St. Bonaventure (61) | 52 | 51 | Virginia (79) | Final | W | 1 |
| 38 | 2022-03-29 | St. Bonaventure (61) | 77 | 84 | Xavier (42) | Final | L | -7 |