Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Texas Lutheran | 33 | 96 | Texas (10) | Final | W | 63 |
| 2 | 2021-11-09 | Houston Baptist (331) | 48 | 92 | Texas (10) | Final | W | 44 |
| 3 | 2021-11-13 | Texas (10) | 74 | 86 | Gonzaga (1) | Final | L | -12 |
| 4 | 2021-11-17 | Northern Colorado (196) | 49 | 62 | Texas (41) | Final | W | 13 |
| 5 | 2021-11-20 | San Jose State (229) | 45 | 79 | Texas (41) | Final | W | 34 |
| 6 | 2021-11-24 | California Baptist (97) | 44 | 68 | Texas (41) | Final | W | 24 |
| 7 | 2021-11-29 | Sam Houston State (268) | 57 | 73 | Texas (37) | Final | W | 16 |
| 8 | 2021-12-03 | UTRGV (161) | 58 | 88 | Texas (41) | Final | W | 30 |
| 9 | 2021-12-09 | Texas (31) | 60 | 64 | Seton Hall (32) | Final | L | -4 |
| 10 | 2021-12-14 | Arkansas-Pine Bluff (303) | 31 | 63 | Texas (41) | Final | W | 32 |
| 11 | 2021-12-19 | Texas (41) | 60 | 53 | Stanford (60) | Final | W | 7 |
| 12 | 2021-12-22 | Alabama State (331) | 48 | 68 | Texas (41) | Final | W | 20 |
| 13 | 2021-12-28 | Incarnate Word (280) | 33 | 78 | Texas (41) | Final | W | 45 |
| 14 | 2022-01-01 | West Virginia (50) | 59 | 74 | Texas (41) | Final | W | 15 |
| 15 | 2022-01-04 | Texas (41) | 70 | 57 | Kansas State (96) | Final | W | 13 |
| 16 | 2022-01-08 | Texas (41) | 51 | 64 | Oklahoma State (57) | Final | L | -13 |
| 17 | 2022-01-11 | Oklahoma (47) | 52 | 66 | Texas (41) | Final | W | 14 |
| 18 | 2022-01-15 | Texas (41) | 70 | 79 | Iowa State (7) | Final | L | -9 |
| 19 | 2022-01-18 | Kansas State (96) | 66 | 65 | Texas (41) | Final | L | -1 |
| 20 | 2022-01-22 | Oklahoma State (57) | 51 | 56 | Texas (41) | Final | W | 5 |
| 21 | 2022-01-25 | Texas (34) | 73 | 50 | TCU (39) | Final | W | 23 |
| 22 | 2022-01-29 | Tennessee (18) | 51 | 52 | Texas (41) | Final | W | 1 |
| 23 | 2022-02-01 | Texas (25) | 64 | 77 | Texas Tech (16) | Final | L | -13 |
| 24 | 2022-02-05 | Iowa State (7) | 41 | 63 | Texas (41) | Final | W | 22 |
| 25 | 2022-02-07 | Kansas (19) | 76 | 79 | Texas (41) | Final | W | 3 |
| 26 | 2022-02-12 | Texas (41) | 63 | 80 | Baylor (58) | Final | L | -17 |
| 27 | 2022-02-15 | Texas (19) | 80 | 78 | Oklahoma (44) | Final (OT) | W | 2 |
| 28 | 2022-02-19 | Texas Tech (12) | 61 | 55 | Texas (19) | Final | L | -6 |
| 29 | 2022-02-23 | TCU (42) | 66 | 75 | Texas (21) | Final | W | 9 |
| 30 | 2022-02-26 | Texas (21) | 82 | 81 | West Virginia (57) | Final | W | 1 |
| 31 | 2022-02-28 | Baylor (3) | 68 | 61 | Texas (19) | Final | L | -7 |
| 32 | 2022-03-05 | Texas (19) | 63 | 70 | Kansas (5) | Final | L | -7 |
| 33 | 2022-03-10 | TCU (37) | 65 | 60 | Texas (23) | Final | L | -5 |
| 34 | 2022-03-18 | Virginia Tech (46) | 73 | 81 | Texas (25) | Final | W | 8 |
| 35 | 2022-03-20 | Texas (25) | 71 | 81 | Purdue (11) | Final | L | -10 |