Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Cedarville | 60 | 94 | Dayton (89) | Final | W | 34 |
| 2 | 2021-11-09 | Illinois-Chicago (284) | 54 | 64 | Dayton (89) | Final | W | 10 |
| 3 | 2021-11-13 | UMass-Lowell (214) | 59 | 58 | Dayton (89) | Final | L | -1 |
| 4 | 2021-11-17 | Lipscomb (190) | 78 | 59 | Dayton (66) | Final | L | -19 |
| 5 | 2021-11-20 | Austin Peay (138) | 87 | 81 | Dayton (66) | Final | L | -6 |
| 6 | 2021-11-25 | Dayton (66) | 76 | 60 | Miami (27) | Final | W | 16 |
| 7 | 2021-11-26 | Dayton (66) | 74 | 73 | Kansas (19) | Final | W | 1 |
| 8 | 2021-11-28 | Dayton (127) | 63 | 61 | Belmont (76) | Final | W | 2 |
| 9 | 2021-12-01 | Alabama State (331) | 54 | 93 | Dayton (66) | Final | W | 39 |
| 10 | 2021-12-04 | Northern Illinois (326) | 41 | 79 | Dayton (66) | Final | W | 38 |
| 11 | 2021-12-08 | Dayton (95) | 69 | 77 | SMU (116) | Final | L | -8 |
| 12 | 2021-12-12 | Virginia Tech (56) | 57 | 62 | Dayton (66) | Final | W | 5 |
| 13 | 2021-12-18 | Dayton (66) | 68 | 76 | Ole Miss (79) | Final | L | -8 |
| 14 | 2021-12-21 | Southern (259) | 60 | 69 | Dayton (66) | Final | W | 9 |
| 15 | 2021-12-30 | Dayton (66) | 0 | 0 | Rhode Island (145) | Postponed | - | - |
| 16 | 2022-01-02 | St. Bonaventure (146) | 0 | 0 | Dayton (66) | Postponed | - | - |
| 17 | 2022-01-05 | Virginia Commonwealth (38) | 53 | 52 | Dayton (66) | Final | L | -1 |
| 18 | 2022-01-08 | Dayton (66) | 83 | 58 | George Washington (104) | Final | W | 25 |
| 19 | 2022-01-11 | Saint Louis (31) | 63 | 68 | Dayton (66) | Final | W | 5 |
| 20 | 2022-01-15 | Dayton (66) | 72 | 52 | Duquesne (121) | Final | W | 20 |
| 21 | 2022-01-18 | St. Bonaventure (146) | 50 | 68 | Dayton (66) | Final | W | 18 |
| 22 | 2022-01-22 | Dayton (66) | 49 | 50 | George Mason (86) | Final | L | -1 |
| 23 | 2022-01-25 | Fordham (165) | 61 | 68 | Dayton (83) | Final | W | 7 |
| 24 | 2022-01-28 | Rhode Island (110) | 51 | 53 | Dayton (83) | Final | W | 2 |
| 25 | 2022-02-02 | Dayton (75) | 82 | 52 | Virginia Commonwealth (51) | Final | W | 30 |
| 26 | 2022-02-05 | Dayton (66) | 61 | 72 | Saint Louis (31) | Final | L | -11 |
| 27 | 2022-02-09 | Duquesne (121) | 54 | 75 | Dayton (66) | Final | W | 21 |
| 28 | 2022-02-12 | George Washington (104) | 54 | 80 | Dayton (66) | Final | W | 26 |
| 29 | 2022-02-14 | Dayton (66) | 63 | 57 | Rhode Island (145) | Final | W | 6 |
| 30 | 2022-02-19 | Dayton (68) | 74 | 62 | Saint Joseph's (164) | Final | W | 12 |
| 31 | 2022-02-23 | Massachusetts (167) | 61 | 82 | Dayton (61) | Final | W | 21 |
| 32 | 2022-02-26 | Dayton (61) | 60 | 62 | La Salle (258) | Final | L | -2 |
| 33 | 2022-03-01 | Dayton (67) | 55 | 53 | Richmond (83) | Final | W | 2 |
| 34 | 2022-03-05 | Davidson (33) | 76 | 82 | Dayton (67) | Final | W | 6 |
| 35 | 2022-03-11 | Massachusetts (170) | 72 | 75 | Dayton (59) | Final | W | 3 |
| 36 | 2022-03-12 | Richmond (89) | 68 | 64 | Dayton (59) | Final | L | -4 |
| 37 | 2022-03-16 | Dayton (66) | 74 | 55 | Toledo (135) | Final | W | 19 |
| 38 | 2022-03-20 | Dayton (62) | 68 | 70 | Vanderbilt (72) | Final | L | -2 |