Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Maine (311) | 47 | 82 | Virginia Tech (41) | Final | L | -35 |
| 2 | 2021-11-12 | Maine-Farmington | 52 | 71 | Maine (350) | Final | W | 19 |
| 3 | 2021-11-12 | Maine-Farmington | 52 | 71 | Maine (311) | Final | W | 19 |
| 4 | 2021-11-15 | Maine (267) | 46 | 90 | Colorado (53) | Final | L | -44 |
| 5 | 2021-11-19 | Maine-Fort Kent | 43 | 75 | Maine (350) | Final | W | 32 |
| 6 | 2021-11-19 | Maine-Fort Kent | 43 | 75 | Maine (267) | Final | W | 32 |
| 7 | 2021-11-23 | Central Connecticut State (353) | 64 | 56 | Maine (292) | Final | L | -8 |
| 8 | 2021-11-27 | Maine (292) | 39 | 71 | Bradley (319) | Final | L | -32 |
| 9 | 2021-12-04 | Maine (350) | 66 | 77 | Columbia (193) | Final | L | -11 |
| 10 | 2021-12-11 | Maine (350) | 47 | 73 | Quinnipiac (189) | Final | L | -26 |
| 11 | 2021-12-18 | New England | 50 | 86 | Maine (350) | Final | W | 36 |
| 12 | 2021-12-21 | Merrimack (134) | 49 | 47 | Maine (350) | Final | L | -2 |
| 13 | 2021-12-30 | Maine (350) | 64 | 80 | Rutgers (112) | Final | L | -16 |
| 14 | 2022-01-02 | Maine (350) | 66 | 69 | NJIT (306) | Final | L | -3 |
| 15 | 2022-01-06 | Hartford | 0 | 0 | Maine (350) | Postponed | - | - |
| 16 | 2022-01-08 | Maine (350) | 72 | 80 | Stony Brook (213) | Final | L | -8 |
| 17 | 2022-01-16 | Binghamton (285) | 73 | 65 | Maine (353) | Final | L | -8 |
| 18 | 2022-01-19 | Maine (350) | 62 | 71 | UMass-Lowell (319) | Final | L | -9 |
| 19 | 2022-01-22 | UMBC (198) | 88 | 46 | Maine (350) | Final | L | -42 |
| 20 | 2022-01-24 | New Hampshire (346) | 64 | 71 | Maine (350) | Final | W | 7 |
| 21 | 2022-01-26 | Maine (354) | 61 | 73 | New Hampshire (226) | Final | L | -12 |
| 22 | 2022-01-29 | Maine (350) | 68 | 81 | Vermont (225) | Final | L | -13 |
| 23 | 2022-01-31 | Hartford (317) | 78 | 66 | Maine (354) | Final | L | -12 |
| 24 | 2022-02-02 | UMass-Lowell (259) | 62 | 50 | Maine (354) | Final | L | -12 |
| 25 | 2022-02-05 | Maine (350) | 60 | 69 | Binghamton (359) | Final | L | -9 |
| 26 | 2022-02-09 | Maine (350) | 73 | 63 | Albany (330) | Final | W | 10 |
| 27 | 2022-02-13 | Stony Brook (193) | 85 | 74 | Maine (352) | Final | L | -11 |
| 28 | 2022-02-16 | Maine (352) | 65 | 75 | Hartford (322) | Final | L | -10 |
| 29 | 2022-02-20 | NJIT (292) | 61 | 65 | Maine (351) | Final | W | 4 |
| 30 | 2022-02-23 | Albany (262) | 72 | 68 | Maine (351) | Final | L | -4 |
| 31 | 2022-02-26 | Maine (351) | 79 | 93 | UMBC (237) | Final | L | -14 |
| 32 | 2022-03-01 | Vermont (78) | 75 | 56 | Maine (352) | Final | L | -19 |