Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Ferris State | 59 | 100 | Xavier (59) | Final | W | 41 |
| 2 | 2021-11-09 | Niagara (221) | 60 | 63 | Xavier (59) | Final | W | 3 |
| 3 | 2021-11-12 | Kent State (107) | 59 | 73 | Xavier (92) | Final | W | 14 |
| 4 | 2021-11-18 | Ohio State (74) | 65 | 71 | Xavier (86) | Final | W | 6 |
| 5 | 2021-11-21 | Norfolk State (137) | 48 | 88 | Xavier (8) | Final | W | 40 |
| 6 | 2021-11-24 | Xavier (92) | 70 | 82 | Iowa State (7) | Final | L | -12 |
| 7 | 2021-11-26 | Xavier (92) | 59 | 58 | Virginia Tech (56) | Final | W | 1 |
| 8 | 2021-12-01 | Central Michigan (311) | 45 | 78 | Xavier (92) | Final | W | 33 |
| 9 | 2021-12-05 | Xavier (14) | 77 | 71 | Oklahoma State (25) | Final | W | 6 |
| 10 | 2021-12-08 | Ball State (185) | 50 | 96 | Xavier (12) | Final | W | 46 |
| 11 | 2021-12-11 | Cincinnati (54) | 63 | 83 | Xavier (92) | Final | W | 20 |
| 12 | 2021-12-15 | Morehead State (233) | 63 | 86 | Xavier (92) | Final | W | 23 |
| 13 | 2021-12-18 | Marquette (106) | 71 | 80 | Xavier (92) | Final | W | 9 |
| 14 | 2021-12-21 | Xavier (92) | 58 | 71 | Villanova (29) | Final | L | -13 |
| 15 | 2021-12-28 | Connecticut (4) | 0 | 0 | Xavier (92) | Postponed | - | - |
| 16 | 2022-01-04 | Xavier (92) | 0 | 0 | Georgetown (83) | Canceled | - | - |
| 17 | 2022-01-07 | Xavier (92) | 87 | 72 | Butler (80) | Final | W | 15 |
| 18 | 2022-01-12 | Villanova (14) | 64 | 60 | Xavier (13) | Final | L | -4 |
| 19 | 2022-01-15 | Creighton (78) | 73 | 80 | Xavier (92) | Final | W | 7 |
| 20 | 2022-01-19 | Xavier (92) | 68 | 67 | DePaul (95) | Final | W | 1 |
| 21 | 2022-01-23 | Xavier (20) | 64 | 75 | Marquette (24) | Final | L | -11 |
| 22 | 2022-01-26 | Providence (13) | 65 | 62 | Xavier (20) | Final | L | -3 |
| 23 | 2022-01-29 | Xavier (92) | 74 | 64 | Creighton (78) | Final | W | 10 |
| 24 | 2022-02-02 | Butler (109) | 66 | 68 | Xavier (18) | Final | W | 2 |
| 25 | 2022-02-05 | DePaul (95) | 69 | 65 | Xavier (92) | Final | L | -4 |
| 26 | 2022-02-09 | Xavier (92) | 71 | 73 | Seton Hall (53) | Final | L | -2 |
| 27 | 2022-02-11 | Connecticut (4) | 68 | 74 | Xavier (92) | Final | W | 6 |
| 28 | 2022-02-16 | St. John's (85) | 86 | 73 | Xavier (25) | Final | L | -13 |
| 29 | 2022-02-19 | Xavier (25) | 61 | 72 | Connecticut (24) | Final | L | -11 |
| 30 | 2022-02-23 | Xavier (29) | 92 | 99 | Providence (11) | Final | L | -7 |
| 31 | 2022-02-26 | Seton Hall (33) | 82 | 66 | Xavier (29) | Final | L | -16 |
| 32 | 2022-03-02 | Xavier (35) | 66 | 81 | St. John's (73) | Final | L | -15 |
| 33 | 2022-03-05 | Georgetown (205) | 75 | 97 | Xavier (35) | Final | W | 22 |
| 34 | 2022-03-09 | Butler (114) | 89 | 82 | Xavier (38) | Final | L | -7 |
| 35 | 2022-03-15 | Cleveland State (190) | 68 | 72 | Xavier (42) | Final | W | 4 |
| 36 | 2022-03-20 | Florida (54) | 56 | 72 | Xavier (42) | Final | W | 16 |
| 37 | 2022-03-22 | Vanderbilt (72) | 73 | 75 | Xavier (42) | Final | W | 2 |
| 38 | 2022-03-29 | St. Bonaventure (61) | 77 | 84 | Xavier (42) | Final | W | 7 |
| 39 | 2022-03-31 | Xavier (42) | 73 | 72 | Texas A&M (38) | Final | W | 1 |