Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Eastern Mennonite | 60 | 83 | Radford (239) | Final | W | 23 |
| 2 | 2021-11-09 | Emory & Henry | 72 | 84 | Radford (239) | Final | W | 12 |
| 3 | 2021-11-12 | Radford (255) | 52 | 73 | Virginia (14) | Final | L | -21 |
| 4 | 2021-11-15 | Radford (315) | 39 | 65 | Virginia Tech (12) | Final | L | -26 |
| 5 | 2021-11-19 | Radford (255) | 64 | 81 | Furman (157) | Final | L | -17 |
| 6 | 2021-11-20 | Radford (255) | 33 | 47 | Navy (149) | Final | L | -14 |
| 7 | 2021-11-24 | William & Mary (141) | 54 | 67 | Radford (255) | Final | W | 13 |
| 8 | 2021-11-28 | Eastern Kentucky (219) | 75 | 88 | Radford (243) | Final | W | 13 |
| 9 | 2021-11-30 | Kentucky Christian | 70 | 79 | Radford (243) | Final | W | 9 |
| 10 | 2021-12-04 | Radford (255) | 51 | 67 | West Virginia (50) | Final | L | -16 |
| 11 | 2021-12-11 | Radford (255) | 70 | 79 | James Madison (202) | Final | L | -9 |
| 12 | 2021-12-13 | Radford (255) | 58 | 67 | George Washington (104) | Final | L | -9 |
| 13 | 2021-12-18 | Radford (255) | 54 | 74 | Davidson (111) | Final | L | -20 |
| 14 | 2021-12-20 | Radford (255) | 0 | 0 | Akron (59) | Cancelled | - | - |
| 15 | 2021-12-29 | Radford (255) | 0 | 0 | UMBC (198) | Cancelled | - | - |
| 16 | 2022-01-01 | Averett | 0 | 0 | Radford (255) | Canceled | - | - |
| 17 | 2022-01-06 | Radford (255) | 82 | 77 | South Carolina Upstate (293) | Final | W | 5 |
| 18 | 2022-01-08 | North Carolina A&T (294) | 73 | 72 | Radford (255) | Final | L | -1 |
| 19 | 2022-01-12 | Longwood (193) | 83 | 75 | Radford (292) | Final (OT) | L | -8 |
| 20 | 2022-01-15 | Radford (255) | 58 | 70 | Campbell (191) | Final | L | -12 |
| 21 | 2022-01-19 | Hampton (260) | 51 | 54 | Radford (255) | Final | W | 3 |
| 22 | 2022-01-22 | UNC-Asheville (244) | 78 | 74 | Radford (255) | Final/OT | L | -4 |
| 23 | 2022-01-26 | Radford (298) | 58 | 63 | High Point (285) | Final | L | -5 |
| 24 | 2022-01-29 | Radford (255) | 42 | 61 | Gardner-Webb (363) | Final | L | -19 |
| 25 | 2022-02-02 | Charleston Southern (342) | 52 | 64 | Radford (305) | Final | W | 12 |
| 26 | 2022-02-05 | Presbyterian (264) | 78 | 70 | Radford (255) | Final | L | -8 |
| 27 | 2022-02-09 | Radford (255) | 48 | 58 | Winthrop (133) | Final | L | -10 |
| 28 | 2022-02-12 | Radford (255) | 60 | 54 | Hampton (260) | Final | W | 6 |
| 29 | 2022-02-16 | Campbell (210) | 67 | 71 | Radford (304) | Final | W | 4 |
| 30 | 2022-02-19 | High Point (249) | 64 | 66 | Radford (304) | Final | W | 2 |
| 31 | 2022-02-23 | Radford (287) | 66 | 71 | Longwood (141) | Final | L | -5 |
| 32 | 2022-02-26 | Radford (287) | 62 | 53 | North Carolina A&T (290) | Final | W | 9 |
| 33 | 2022-03-02 | North Carolina A&T (299) | 78 | 71 | Radford (284) | Final | L | -7 |