Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Youngstown State (258) | 59 | 75 | Penn State (58) | Final | W | 16 |
| 2 | 2021-11-15 | Penn State (76) | 56 | 81 | Massachusetts (206) | Final | L | -25 |
| 3 | 2021-11-18 | St. Francis (NY) (328) | 59 | 74 | Penn State (76) | Final | W | 15 |
| 4 | 2021-11-22 | Cornell (187) | 74 | 85 | Penn State (129) | Final | W | 11 |
| 5 | 2021-11-26 | Penn State (129) | 63 | 68 | LSU (77) | Final/OT | L | -5 |
| 6 | 2021-11-27 | Penn State (175) | 60 | 45 | Oregon State (240) | Final | W | 15 |
| 7 | 2021-12-01 | Miami (27) | 63 | 58 | Penn State (129) | Final | L | -5 |
| 8 | 2021-12-05 | Ohio State (63) | 76 | 64 | Penn State (93) | Final | L | -12 |
| 9 | 2021-12-08 | Wagner (75) | 54 | 74 | Penn State (129) | Final | W | 20 |
| 10 | 2021-12-11 | Penn State (129) | 64 | 80 | Michigan State (10) | Final | L | -16 |
| 11 | 2021-12-18 | Penn State (129) | 0 | 0 | Virginia Commonwealth (38) | Cancelled | - | - |
| 12 | 2021-12-22 | Quinnipiac (189) | 0 | 0 | Penn State (129) | Cancelled | - | - |
| 13 | 2021-12-29 | Delaware State (361) | 0 | 0 | Penn State (129) | Cancelled | - | - |
| 14 | 2022-01-02 | Indiana (46) | 58 | 61 | Penn State (129) | Final | W | 3 |
| 15 | 2022-01-05 | Penn State (129) | 74 | 70 | Northwestern (75) | Final | W | 4 |
| 16 | 2022-01-08 | Purdue (8) | 74 | 67 | Penn State (129) | Final | L | -7 |
| 17 | 2022-01-11 | Rutgers (112) | 49 | 66 | Penn State (129) | Final | W | 17 |
| 18 | 2022-01-16 | Penn State (71) | 56 | 61 | Ohio State (22) | Final | L | -5 |
| 19 | 2022-01-19 | Minnesota (87) | 0 | 0 | Penn State (129) | Postponed | - | - |
| 20 | 2022-01-22 | Penn State (129) | 51 | 68 | Iowa (28) | Final | L | -17 |
| 21 | 2022-01-26 | Penn State (79) | 57 | 74 | Indiana (42) | Final | L | -17 |
| 22 | 2022-01-31 | Iowa (32) | 86 | 90 | Penn State (91) | Final (2OT) | W | 4 |
| 23 | 2022-02-05 | Penn State (129) | 49 | 51 | Wisconsin (24) | Final | L | -2 |
| 24 | 2022-02-08 | Michigan (64) | 58 | 57 | Penn State (83) | Final | L | -1 |
| 25 | 2022-02-12 | Penn State (129) | 70 | 76 | Minnesota (87) | Final | L | -6 |
| 26 | 2022-02-15 | Michigan State (18) | 58 | 62 | Penn State (95) | Final | W | 4 |
| 27 | 2022-02-17 | Minnesota (87) | 46 | 67 | Penn State (129) | Final | W | 21 |
| 28 | 2022-02-21 | Penn State (80) | 61 | 67 | Maryland (93) | Final | L | -6 |
| 29 | 2022-02-25 | Northwestern (89) | 60 | 67 | Penn State (80) | Final | W | 7 |
| 30 | 2022-02-27 | Nebraska (189) | 93 | 70 | Penn State (94) | Final | L | -23 |
| 31 | 2022-03-03 | Penn State (94) | 55 | 60 | Illinois (20) | Final | L | -5 |
| 32 | 2022-03-06 | Penn State (100) | 58 | 59 | Rutgers (63) | Final | L | -1 |
| 33 | 2022-03-09 | Minnesota (103) | 51 | 60 | Penn State (100) | Final | W | 9 |
| 34 | 2022-03-10 | Penn State (100) | 71 | 68 | Ohio State (30) | Final | W | 3 |
| 35 | 2022-03-11 | Penn State (100) | 61 | 69 | Purdue (9) | Final | L | -8 |