Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Robert Morris (319) | 59 | 69 | Central Florida (100) | Final | W | 10 |
| 2 | 2021-11-13 | Central Florida (100) | 95 | 89 | Miami (144) | Final | W | 6 |
| 3 | 2021-11-16 | Jacksonville (111) | 54 | 63 | Central Florida (85) | Final | W | 9 |
| 4 | 2021-11-20 | Central Florida (43) | 75 | 59 | Evansville (302) | Final | W | 16 |
| 5 | 2021-11-27 | Oklahoma (56) | 65 | 62 | Central Florida (43) | Final | L | -3 |
| 6 | 2021-12-01 | Central Florida (43) | 68 | 85 | Auburn (37) | Final | L | -17 |
| 7 | 2021-12-05 | Bethune-Cookman (296) | 45 | 81 | Central Florida (90) | Final | W | 36 |
| 8 | 2021-12-11 | North Carolina A&T (294) | 68 | 83 | Central Florida (43) | Final | W | 15 |
| 9 | 2021-12-15 | Central Florida (43) | 65 | 48 | Temple (169) | Final | W | 17 |
| 10 | 2021-12-18 | Central Florida (43) | 0 | 0 | Florida State (64) | Cancelled | - | - |
| 11 | 2021-12-18 | Florida State | 0 | 0 | Central Florida | Cancelled | - | - |
| 12 | 2021-12-22 | North Alabama (335) | 64 | 75 | Central Florida (43) | Final | W | 11 |
| 13 | 2021-12-30 | Michigan (1) | 71 | 85 | Central Florida (43) | Final | W | 14 |
| 14 | 2022-01-02 | Central Florida (43) | 60 | 72 | SMU (45) | Final | L | -12 |
| 15 | 2022-01-05 | Temple (169) | 66 | 62 | Central Florida (43) | Final | L | -4 |
| 16 | 2022-01-08 | Tulsa (55) | 0 | 0 | Central Florida (43) | Postponed | - | - |
| 17 | 2022-01-12 | Memphis (54) | 64 | 74 | Central Florida (61) | Final | W | 10 |
| 18 | 2022-01-15 | Central Florida (43) | 51 | 75 | South Florida (52) | Final | L | -24 |
| 19 | 2022-01-18 | Central Florida (43) | 92 | 85 | East Carolina (252) | Final/OT | W | 7 |
| 20 | 2022-01-22 | Tulane (167) | 66 | 68 | Central Florida (43) | Final | W | 2 |
| 21 | 2022-01-26 | Central Florida (70) | 79 | 84 | Wichita State (90) | Final | L | -5 |
| 22 | 2022-01-29 | Houston (5) | 63 | 49 | Central Florida (43) | Final | L | -14 |
| 23 | 2022-02-03 | South Florida (52) | 49 | 68 | Central Florida (43) | Final | W | 19 |
| 24 | 2022-02-05 | Central Florida (43) | 60 | 88 | Memphis (136) | Final | L | -28 |
| 25 | 2022-02-08 | Wichita State (78) | 66 | 71 | Central Florida (93) | Final | W | 5 |
| 26 | 2022-02-14 | Tulsa (55) | 67 | 76 | Central Florida (43) | Final | W | 9 |
| 27 | 2022-02-17 | Central Florida (43) | 52 | 70 | Houston (5) | Final | L | -18 |
| 28 | 2022-02-20 | East Carolina (148) | 66 | 69 | Central Florida (81) | Final | W | 3 |
| 29 | 2022-02-23 | Cincinnati (95) | 61 | 75 | Central Florida (81) | Final | W | 14 |
| 30 | 2022-03-03 | Central Florida (76) | 67 | 82 | Tulane (117) | Final | L | -15 |
| 31 | 2022-03-06 | Central Florida (88) | 72 | 73 | Tulsa (197) | Final | L | -1 |
| 32 | 2022-03-10 | South Florida (237) | 58 | 60 | Central Florida (88) | Final | W | 2 |
| 33 | 2022-03-11 | Central Florida (88) | 69 | 85 | Memphis (43) | Final | L | -16 |