Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Birmingham-Southern | 98 | 105 | Lipscomb (226) | Final | W | 7 |
| 2 | 2021-11-12 | Lipscomb (190) | 77 | 86 | Charleston (123) | Final | L | -9 |
| 3 | 2021-11-13 | South Carolina State (345) | 81 | 93 | Lipscomb (226) | Final | W | 12 |
| 4 | 2021-11-14 | Loyola-Maryland (325) | 65 | 70 | Lipscomb (190) | Final | W | 5 |
| 5 | 2021-11-17 | Lipscomb (190) | 78 | 59 | Dayton (66) | Final | W | 19 |
| 6 | 2021-11-23 | Lipscomb (176) | 77 | 88 | Tennessee Tech (272) | Final | L | -11 |
| 7 | 2021-11-28 | Kentucky Christian | 67 | 86 | Lipscomb (198) | Final | W | 19 |
| 8 | 2021-12-02 | Lipscomb (198) | 65 | 94 | Belmont (76) | Final | L | -29 |
| 9 | 2021-12-05 | Chattanooga (61) | 85 | 64 | Lipscomb (198) | Final | L | -21 |
| 10 | 2021-12-08 | Lipscomb (214) | 59 | 76 | Miami (101) | Final | L | -17 |
| 11 | 2021-12-12 | Tennessee State (165) | 73 | 65 | Lipscomb (190) | Final | L | -8 |
| 12 | 2021-12-15 | Lipscomb (190) | 60 | 97 | Florida State (64) | Final | L | -37 |
| 13 | 2021-12-19 | Tennessee Wesleyan | 64 | 98 | Lipscomb (190) | Final | W | 34 |
| 14 | 2021-12-22 | Lipscomb (190) | 60 | 95 | LSU (77) | Final | L | -35 |
| 15 | 2021-12-30 | Alabama A&M (286) | 63 | 66 | Lipscomb (190) | Final | W | 3 |
| 16 | 2022-01-04 | North Alabama (335) | 74 | 84 | Lipscomb (190) | Final | W | 10 |
| 17 | 2022-01-09 | Lipscomb (269) | 88 | 93 | Central Arkansas (289) | Final | L | -5 |
| 18 | 2022-01-11 | Lipscomb (190) | 83 | 88 | Jacksonville State (227) | Final | L | -5 |
| 19 | 2022-01-15 | Bellarmine (266) | 77 | 71 | Lipscomb (190) | Final | L | -6 |
| 20 | 2022-01-18 | Lipscomb (190) | 72 | 86 | Eastern Kentucky (288) | Final | L | -14 |
| 21 | 2022-01-22 | Kennesaw State (142) | 73 | 77 | Lipscomb (190) | Final | W | 4 |
| 22 | 2022-01-27 | Lipscomb (190) | 59 | 66 | Jacksonville (281) | Final | L | -7 |
| 23 | 2022-01-29 | Lipscomb (190) | 77 | 74 | North Florida (345) | Final | W | 3 |
| 24 | 2022-02-03 | Stetson (301) | 77 | 71 | Lipscomb (190) | Final | L | -6 |
| 25 | 2022-02-05 | Florida Gulf Coast (241) | 77 | 68 | Lipscomb (190) | Final | L | -9 |
| 26 | 2022-02-08 | Lipscomb (290) | 69 | 78 | Liberty (105) | Final | L | -9 |
| 27 | 2022-02-12 | Eastern Kentucky (288) | 73 | 83 | Lipscomb (190) | Final | W | 10 |
| 28 | 2022-02-16 | Jacksonville State (156) | 78 | 67 | Lipscomb (282) | Final | L | -11 |
| 29 | 2022-02-19 | Lipscomb (282) | 75 | 72 | North Alabama (294) | Final | W | 3 |
| 30 | 2022-02-23 | Lipscomb (282) | 73 | 76 | Bellarmine (186) | Final | L | -3 |
| 31 | 2022-02-26 | Central Arkansas (285) | 66 | 81 | Lipscomb (282) | Final | W | 15 |
| 32 | 2022-03-01 | North Florida (262) | 65 | 74 | Lipscomb (281) | Final | W | 9 |
| 33 | 2022-03-03 | Lipscomb (281) | 47 | 52 | Liberty (120) | Final | L | -5 |