Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-24 | Louisiana (175) | 68 | 73 | Alabama (6) | Final | W | 5 |
| 2 | 2021-11-09 | Louisiana Tech (70) | 64 | 93 | Alabama (6) | Final | W | 29 |
| 3 | 2021-11-12 | South Dakota State (268) | 88 | 104 | Alabama (15) | Final | W | 16 |
| 4 | 2021-11-16 | South Alabama (186) | 68 | 73 | Alabama (8) | Final | W | 5 |
| 5 | 2021-11-19 | Oakland (172) | 59 | 86 | Alabama (15) | Final | W | 27 |
| 6 | 2021-11-25 | Alabama (15) | 68 | 72 | Iona (220) | Final | L | -4 |
| 7 | 2021-11-26 | Alabama (15) | 80 | 71 | Drake (217) | Final | W | 9 |
| 8 | 2021-11-28 | Miami (156) | 64 | 96 | Alabama (11) | Final | W | 32 |
| 9 | 2021-12-04 | Alabama (15) | 91 | 82 | Gonzaga (11) | Final | W | 9 |
| 10 | 2021-12-11 | Houston (5) | 82 | 83 | Alabama (15) | Final | W | 1 |
| 11 | 2021-12-14 | Alabama (15) | 78 | 92 | Memphis (136) | Final | L | -14 |
| 12 | 2021-12-18 | Jacksonville State (227) | 59 | 65 | Alabama (15) | Final | W | 6 |
| 13 | 2021-12-21 | Davidson (111) | 79 | 78 | Alabama (15) | Final | L | -1 |
| 14 | 2021-12-29 | Tennessee (18) | 68 | 73 | Alabama (15) | Final | W | 5 |
| 15 | 2022-01-05 | Alabama (15) | 83 | 70 | Florida (6) | Final | W | 13 |
| 16 | 2022-01-08 | Alabama (15) | 86 | 92 | Missouri (51) | Final | L | -6 |
| 17 | 2022-01-11 | Auburn (37) | 81 | 77 | Alabama (15) | Final | L | -4 |
| 18 | 2022-01-15 | Alabama (15) | 76 | 78 | Mississippi State (100) | Final | L | -2 |
| 19 | 2022-01-19 | LSU (77) | 67 | 70 | Alabama (15) | Final | W | 3 |
| 20 | 2022-01-22 | Missouri (51) | 76 | 86 | Alabama (15) | Final | W | 10 |
| 21 | 2022-01-25 | Alabama (21) | 76 | 82 | Georgia (222) | Final | L | -6 |
| 22 | 2022-01-29 | Baylor (58) | 78 | 87 | Alabama (15) | Final | W | 9 |
| 23 | 2022-02-01 | Alabama (20) | 81 | 100 | Auburn (1) | Final | L | -19 |
| 24 | 2022-02-05 | Kentucky (26) | 66 | 55 | Alabama (15) | Final | L | -11 |
| 25 | 2022-02-09 | Alabama (15) | 97 | 83 | Ole Miss (79) | Final | W | 14 |
| 26 | 2022-02-12 | Arkansas (16) | 67 | 68 | Alabama (15) | Final | W | 1 |
| 27 | 2022-02-16 | Mississippi State (60) | 75 | 80 | Alabama (22) | Final | W | 5 |
| 28 | 2022-02-19 | Alabama (22) | 81 | 90 | Kentucky (5) | Final | L | -9 |
| 29 | 2022-02-22 | Alabama (22) | 74 | 72 | Vanderbilt (73) | Final | W | 2 |
| 30 | 2022-02-26 | South Carolina (71) | 71 | 90 | Alabama (22) | Final | W | 19 |
| 31 | 2022-03-02 | Texas A&M (62) | 87 | 71 | Alabama (21) | Final | L | -16 |
| 32 | 2022-03-05 | Alabama (21) | 77 | 80 | LSU (25) | Final | L | -3 |
| 33 | 2022-03-10 | Vanderbilt (80) | 82 | 76 | Alabama (26) | Final | L | -6 |
| 34 | 2022-03-18 | Notre Dame (57) | 78 | 64 | Alabama (28) | Final | L | -14 |