Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Florida Memorial | 67 | 74 | Stetson (236) | Final | W | 7 |
| 2 | 2021-11-12 | Stetson (301) | 52 | 77 | Georgia Tech (158) | Final | L | -25 |
| 3 | 2021-11-17 | Stetson (301) | 65 | 80 | Miami (OH) (40) | Final | L | -15 |
| 4 | 2021-11-19 | Stetson (301) | 60 | 59 | Lamar (279) | Final | W | 1 |
| 5 | 2021-11-27 | Campbell (117) | 60 | 58 | Stetson (264) | Final | L | -2 |
| 6 | 2021-12-01 | Stetson (301) | 73 | 83 | Florida Atlantic (128) | Final | L | -10 |
| 7 | 2021-12-04 | Stetson (301) | 65 | 72 | Florida International (214) | Final | L | -7 |
| 8 | 2021-12-11 | Ohio (218) | 55 | 45 | Stetson (301) | Final | L | -10 |
| 9 | 2021-12-13 | Johnson (FL) | 58 | 104 | Stetson (317) | Final | W | 46 |
| 10 | 2021-12-16 | Charleston (123) | 59 | 67 | Stetson (301) | Final | W | 8 |
| 11 | 2021-12-20 | Stetson (301) | 72 | 82 | Miami (27) | Final | L | -10 |
| 12 | 2021-12-22 | Piedmont | 53 | 97 | Stetson (301) | Final | W | 44 |
| 13 | 2021-12-30 | Point | 65 | 77 | Stetson (301) | Final | W | 12 |
| 14 | 2022-01-04 | Liberty (93) | 75 | 59 | Stetson (301) | Final | L | -16 |
| 15 | 2022-01-08 | Stetson (301) | 68 | 66 | North Florida (345) | Final/OT | W | 2 |
| 16 | 2022-01-11 | Stetson (301) | 50 | 57 | Jacksonville (281) | Final | L | -7 |
| 17 | 2022-01-15 | Kennesaw State (142) | 77 | 49 | Stetson (301) | Final | L | -28 |
| 18 | 2022-01-18 | Florida Gulf Coast (241) | 93 | 91 | Stetson (301) | Final/OT | L | -2 |
| 19 | 2022-01-22 | Stetson (301) | 67 | 65 | North Alabama (335) | Final | W | 2 |
| 20 | 2022-01-27 | Bellarmine (266) | 72 | 47 | Stetson (301) | Final | L | -25 |
| 21 | 2022-01-29 | Eastern Kentucky (288) | 95 | 113 | Stetson (301) | Final | W | 18 |
| 22 | 2022-02-03 | Stetson (301) | 77 | 71 | Lipscomb (190) | Final | W | 6 |
| 23 | 2022-02-05 | Stetson (301) | 75 | 79 | Central Arkansas (143) | Final | L | -4 |
| 24 | 2022-02-09 | Jacksonville State (227) | 57 | 63 | Stetson (301) | Final | W | 6 |
| 25 | 2022-02-12 | Stetson (301) | 82 | 89 | Florida Gulf Coast (241) | Final/OT | L | -7 |
| 26 | 2022-02-16 | Jacksonville (184) | 67 | 45 | Stetson (280) | Final | L | -22 |
| 27 | 2022-02-19 | Stetson (280) | 82 | 88 | Liberty (112) | Final | L | -6 |
| 28 | 2022-02-23 | Stetson (288) | 71 | 75 | Kennesaw State (256) | Final | L | -4 |
| 29 | 2022-02-26 | North Florida (260) | 74 | 69 | Stetson (288) | Final | L | -5 |
| 30 | 2022-03-01 | Stetson (295) | 73 | 74 | Central Arkansas (291) | Final | L | -1 |