Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Kennesaw State (327) | 73 | 84 | Iowa State (264) | Final | W | 11 |
| 2 | 2021-11-12 | Oregon State (144) | 50 | 60 | Iowa State (7) | Final | W | 10 |
| 3 | 2021-11-16 | Alabama State (354) | 60 | 68 | Iowa State (50) | Final | W | 8 |
| 4 | 2021-11-21 | Grambling (334) | 47 | 82 | Iowa State (60) | Final | W | 35 |
| 5 | 2021-11-24 | Xavier (92) | 70 | 82 | Iowa State (7) | Final | W | 12 |
| 6 | 2021-11-26 | Iowa State (7) | 78 | 59 | Memphis (136) | Final | W | 19 |
| 7 | 2021-12-01 | Arkansas-Pine Bluff (303) | 64 | 83 | Iowa State (7) | Final | W | 19 |
| 8 | 2021-12-04 | Iowa State (7) | 64 | 58 | Creighton (78) | Final | W | 6 |
| 9 | 2021-12-09 | Iowa (23) | 53 | 73 | Iowa State (7) | Final | W | 20 |
| 10 | 2021-12-12 | Jackson State (329) | 37 | 47 | Iowa State (7) | Final | W | 10 |
| 11 | 2021-12-19 | Southeastern Louisiana (318) | 54 | 77 | Iowa State (7) | Final | W | 23 |
| 12 | 2021-12-21 | Chicago State (351) | 48 | 79 | Iowa State (7) | Final | W | 31 |
| 13 | 2022-01-01 | Baylor (58) | 77 | 72 | Iowa State (7) | Final | L | -5 |
| 14 | 2022-01-05 | Texas Tech (20) | 47 | 51 | Iowa State (7) | Final | W | 4 |
| 15 | 2022-01-08 | Iowa State (7) | 66 | 79 | Oklahoma (47) | Final | L | -13 |
| 16 | 2022-01-11 | Iowa State (7) | 61 | 62 | Kansas (19) | Final | L | -1 |
| 17 | 2022-01-15 | Texas (41) | 70 | 79 | Iowa State (7) | Final | W | 9 |
| 18 | 2022-01-18 | Iowa State (7) | 60 | 72 | Texas Tech (20) | Final | L | -12 |
| 19 | 2022-01-22 | TCU (32) | 59 | 44 | Iowa State (7) | Final | L | -15 |
| 20 | 2022-01-26 | Iowa State (26) | 84 | 81 | Oklahoma State (55) | Final (OT) | W | 3 |
| 21 | 2022-01-29 | Missouri (51) | 50 | 67 | Iowa State (7) | Final | W | 17 |
| 22 | 2022-02-01 | Kansas (5) | 70 | 61 | Iowa State (23) | Final | L | -9 |
| 23 | 2022-02-05 | Iowa State (7) | 41 | 63 | Texas (41) | Final | L | -22 |
| 24 | 2022-02-08 | Iowa State (30) | 63 | 79 | West Virginia (47) | Final | L | -16 |
| 25 | 2022-02-12 | Kansas State (96) | 75 | 69 | Iowa State (7) | Final/OT | L | -6 |
| 26 | 2022-02-15 | Iowa State (39) | 54 | 51 | TCU (36) | Final | W | 3 |
| 27 | 2022-02-19 | Oklahoma (44) | 54 | 75 | Iowa State (39) | Final | W | 21 |
| 28 | 2022-02-23 | West Virginia (57) | 81 | 84 | Iowa State (32) | Final | W | 3 |
| 29 | 2022-02-26 | Iowa State (32) | 74 | 73 | Kansas State (67) | Final | W | 1 |
| 30 | 2022-03-02 | Oklahoma State (71) | 53 | 36 | Iowa State (29) | Final | L | -17 |
| 31 | 2022-03-05 | Iowa State (29) | 68 | 75 | Baylor (3) | Final | L | -7 |
| 32 | 2022-03-10 | Iowa State (35) | 41 | 72 | Texas Tech (14) | Final | L | -31 |
| 33 | 2022-03-18 | Iowa State (39) | 59 | 54 | LSU (23) | Final | W | 5 |
| 34 | 2022-03-20 | Iowa State (39) | 54 | 49 | Wisconsin (15) | Final | W | 5 |
| 35 | 2022-03-25 | Iowa State (39) | 56 | 70 | Miami (52) | Final | L | -14 |