Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Southern Indiana | 54 | 68 | Auburn (71) | Final | W | 14 |
| 2 | 2021-11-09 | Morehead State (103) | 54 | 77 | Auburn (71) | Final | W | 23 |
| 3 | 2021-11-12 | Louisiana-Monroe (358) | 65 | 93 | Auburn (37) | Final | W | 28 |
| 4 | 2021-11-19 | Auburn (37) | 58 | 52 | South Florida (52) | Final | W | 6 |
| 5 | 2021-11-24 | Connecticut (4) | 115 | 109 | Auburn (37) | Final/2OT | L | -6 |
| 6 | 2021-11-25 | Auburn (37) | 62 | 53 | Loyola-Chicago (263) | Final | W | 9 |
| 7 | 2021-11-26 | Syracuse (84) | 68 | 89 | Auburn (37) | Final | W | 21 |
| 8 | 2021-12-01 | Central Florida (43) | 68 | 85 | Auburn (37) | Final | W | 17 |
| 9 | 2021-12-04 | Yale (81) | 64 | 86 | Auburn (37) | Final | W | 22 |
| 10 | 2021-12-11 | Nebraska (13) | 68 | 99 | Auburn (37) | Final | W | 31 |
| 11 | 2021-12-14 | North Alabama (335) | 44 | 70 | Auburn (37) | Final | W | 26 |
| 12 | 2021-12-18 | Auburn (37) | 74 | 70 | Saint Louis (31) | Final | W | 4 |
| 13 | 2021-12-22 | Murray State (116) | 58 | 71 | Auburn (37) | Final | W | 13 |
| 14 | 2021-12-29 | LSU (77) | 55 | 70 | Auburn (37) | Final | W | 15 |
| 15 | 2022-01-04 | Auburn (37) | 81 | 66 | South Carolina (110) | Final | W | 15 |
| 16 | 2022-01-08 | Florida (6) | 73 | 85 | Auburn (37) | Final | W | 12 |
| 17 | 2022-01-11 | Auburn (37) | 81 | 77 | Alabama (15) | Final | W | 4 |
| 18 | 2022-01-15 | Auburn (37) | 80 | 71 | Ole Miss (79) | Final | W | 9 |
| 19 | 2022-01-19 | Georgia (35) | 60 | 83 | Auburn (37) | Final | W | 23 |
| 20 | 2022-01-22 | Kentucky (26) | 71 | 80 | Auburn (37) | Final | W | 9 |
| 21 | 2022-01-25 | Auburn (1) | 55 | 54 | Missouri (145) | Final | W | 1 |
| 22 | 2022-01-29 | Oklahoma (47) | 68 | 86 | Auburn (37) | Final | W | 18 |
| 23 | 2022-02-01 | Alabama (20) | 81 | 100 | Auburn (1) | Final | W | 19 |
| 24 | 2022-02-05 | Auburn (37) | 74 | 72 | Georgia (35) | Final | W | 2 |
| 25 | 2022-02-08 | Auburn (1) | 76 | 80 | Arkansas (29) | Final (OT) | L | -4 |
| 26 | 2022-02-12 | Texas A&M (39) | 58 | 75 | Auburn (37) | Final | W | 17 |
| 27 | 2022-02-16 | Vanderbilt (79) | 80 | 94 | Auburn (3) | Final | W | 14 |
| 28 | 2022-02-19 | Auburn (3) | 62 | 63 | Florida (47) | Final | L | -1 |
| 29 | 2022-02-23 | Ole Miss (101) | 64 | 77 | Auburn (3) | Final | W | 13 |
| 30 | 2022-02-26 | Auburn (3) | 62 | 67 | Tennessee (14) | Final | L | -5 |
| 31 | 2022-03-02 | Auburn (4) | 81 | 68 | Mississippi State (57) | Final (OT) | W | 13 |
| 32 | 2022-03-05 | South Carolina (65) | 71 | 82 | Auburn (4) | Final | W | 11 |
| 33 | 2022-03-11 | Texas A&M (53) | 67 | 62 | Auburn (4) | Final | L | -5 |
| 34 | 2022-03-18 | Jacksonville State (140) | 61 | 80 | Auburn (6) | Final | W | 19 |
| 35 | 2022-03-20 | Miami (52) | 79 | 61 | Auburn (6) | Final | L | -18 |