Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Cal State-Northridge (262) | 49 | 89 | USC (16) | Final | W | 40 |
| 2 | 2021-11-13 | USC (16) | 76 | 71 | Temple (166) | Final | W | 5 |
| 3 | 2021-11-16 | USC (22) | 78 | 61 | Florida Gulf Coast (222) | Final | W | 17 |
| 4 | 2021-11-22 | Dixie State (307) | 71 | 98 | USC (44) | Final | W | 27 |
| 5 | 2021-11-25 | USC (71) | 70 | 55 | Saint Joseph's (99) | Final | W | 15 |
| 6 | 2021-11-26 | USC (71) | 58 | 43 | San Diego State (48) | Final | W | 15 |
| 7 | 2021-12-01 | Utah (130) | 73 | 93 | USC (71) | Final | W | 20 |
| 8 | 2021-12-04 | USC (71) | 63 | 61 | Washington State (179) | Final | W | 2 |
| 9 | 2021-12-07 | Eastern Kentucky (288) | 68 | 80 | USC (71) | Final | W | 12 |
| 10 | 2021-12-12 | Long Beach State (278) | 62 | 73 | USC (71) | Final | W | 11 |
| 11 | 2021-12-15 | UC-Irvine (119) | 61 | 66 | USC (71) | Final | W | 5 |
| 12 | 2021-12-18 | Georgia Tech (158) | 53 | 67 | USC (71) | Final | W | 14 |
| 13 | 2021-12-21 | USC (71) | 0 | 0 | Oklahoma State (57) | Cancelled | - | - |
| 14 | 2021-12-21 | Oklahoma State | 0 | 0 | USC | Cancelled | - | - |
| 15 | 2021-12-30 | Arizona State (61) | 0 | 0 | USC (71) | Postponed | - | - |
| 16 | 2022-01-02 | Arizona (2) | 0 | 0 | USC (71) | Postponed | - | - |
| 17 | 2022-01-06 | USC (71) | 77 | 63 | California (65) | Final | W | 14 |
| 18 | 2022-01-08 | USC (71) | 0 | 0 | Stanford (60) | Postponed | - | - |
| 19 | 2022-01-11 | USC (71) | 69 | 75 | Stanford (60) | Final | L | -6 |
| 20 | 2022-01-13 | Oregon State (144) | 71 | 81 | USC (71) | Final | W | 10 |
| 21 | 2022-01-15 | Oregon (102) | 79 | 69 | USC (71) | Final | L | -10 |
| 22 | 2022-01-20 | USC (71) | 61 | 58 | Colorado (73) | Final | W | 3 |
| 23 | 2022-01-22 | USC (71) | 79 | 67 | Utah (130) | Final | W | 12 |
| 24 | 2022-01-24 | Arizona State (61) | 56 | 78 | USC (71) | Final | W | 22 |
| 25 | 2022-01-27 | Stanford (60) | 64 | 61 | USC (71) | Final | L | -3 |
| 26 | 2022-01-29 | California (65) | 72 | 79 | USC (71) | Final | W | 7 |
| 27 | 2022-02-03 | USC (71) | 58 | 53 | Arizona State (61) | Final | W | 5 |
| 28 | 2022-02-05 | USC (71) | 63 | 72 | Arizona (2) | Final | L | -9 |
| 29 | 2022-02-12 | UCLA (30) | 64 | 67 | USC (71) | Final | W | 3 |
| 30 | 2022-02-17 | Washington (72) | 69 | 79 | USC (71) | Final | W | 10 |
| 31 | 2022-02-20 | Washington State (76) | 60 | 62 | USC (18) | Final | W | 2 |
| 32 | 2022-02-24 | USC (18) | 94 | 91 | Oregon State (271) | Final | W | 3 |
| 33 | 2022-02-26 | USC (18) | 70 | 69 | Oregon (59) | Final | W | 1 |
| 34 | 2022-03-01 | Arizona (2) | 91 | 71 | USC (18) | Final | L | -20 |
| 35 | 2022-03-05 | USC (18) | 68 | 75 | UCLA (15) | Final | L | -7 |
| 36 | 2022-03-10 | Washington (102) | 61 | 65 | USC (24) | Final | W | 4 |
| 37 | 2022-03-11 | USC (24) | 59 | 69 | UCLA (13) | Final | L | -10 |
| 38 | 2022-03-18 | Miami (52) | 68 | 66 | USC (24) | Final | L | -2 |