Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Canisius (202) | 67 | 77 | Miami (144) | Final | L | -10 |
| 2 | 2021-11-12 | Canisius (328) | 71 | 83 | East Carolina (252) | Final | L | -12 |
| 3 | 2021-11-14 | Canisius (328) | 60 | 69 | St. Bonaventure (146) | Final | L | -9 |
| 4 | 2021-11-20 | Canisius (328) | 70 | 80 | Cleveland State (308) | Final | L | -10 |
| 5 | 2021-11-22 | Fredonia | 40 | 106 | Canisius (318) | Final | W | 66 |
| 6 | 2021-11-24 | Coppin State (360) | 75 | 76 | Canisius (328) | Final | W | 1 |
| 7 | 2021-11-29 | Cornell (92) | 89 | 75 | Canisius (269) | Final | L | -14 |
| 8 | 2021-12-03 | Fairfield (204) | 74 | 68 | Canisius (328) | Final | L | -6 |
| 9 | 2021-12-05 | Monmouth (49) | 79 | 65 | Canisius (269) | Final | L | -14 |
| 10 | 2021-12-08 | Canisius (278) | 62 | 75 | Northern Kentucky (281) | Final | L | -13 |
| 11 | 2021-12-11 | Canisius (328) | 43 | 71 | Youngstown State (231) | Final | L | -28 |
| 12 | 2021-12-18 | Buffalo (219) | 64 | 65 | Canisius (328) | Final | W | 1 |
| 13 | 2021-12-22 | Florida Gulf Coast (241) | 90 | 97 | Canisius (328) | Final/OT | W | 7 |
| 14 | 2021-12-31 | Canisius (328) | 0 | 0 | Saint Peter's (200) | Postponed | - | - |
| 15 | 2022-01-02 | Canisius (328) | 0 | 0 | Siena (160) | Postponed | - | - |
| 16 | 2022-01-11 | Quinnipiac (189) | 67 | 79 | Canisius (328) | Final | W | 12 |
| 17 | 2022-01-13 | Canisius (328) | 58 | 68 | Niagara (342) | Final | L | -10 |
| 18 | 2022-01-16 | Canisius (277) | 75 | 80 | Manhattan (150) | Final | L | -5 |
| 19 | 2022-01-18 | Canisius (328) | 57 | 65 | Saint Peter's (200) | Final | L | -8 |
| 20 | 2022-01-21 | Rider (304) | 69 | 70 | Canisius (277) | Final | W | 1 |
| 21 | 2022-01-23 | Saint Peter's (209) | 60 | 63 | Canisius (263) | Final | W | 3 |
| 22 | 2022-01-28 | Canisius (263) | 67 | 72 | Monmouth (104) | Final | L | -5 |
| 23 | 2022-01-30 | Canisius (269) | 62 | 70 | Rider (292) | Final | L | -8 |
| 24 | 2022-02-01 | Canisius (269) | 65 | 73 | Siena (218) | Final | L | -8 |
| 25 | 2022-02-04 | Iona (31) | 70 | 62 | Canisius (269) | Final | L | -8 |
| 26 | 2022-02-06 | Manhattan (307) | 70 | 77 | Canisius (328) | Final | W | 7 |
| 27 | 2022-02-12 | Canisius (328) | 70 | 71 | Marist (178) | Final | L | -1 |
| 28 | 2022-02-14 | Canisius (328) | 76 | 80 | Fairfield (204) | Final/OT | L | -4 |
| 29 | 2022-02-19 | Niagara (206) | 65 | 54 | Canisius (269) | Final | L | -11 |
| 30 | 2022-02-25 | Canisius (276) | 65 | 72 | Iona (46) | Final | L | -7 |
| 31 | 2022-02-27 | Canisius (269) | 72 | 67 | Quinnipiac (244) | Final | W | 5 |
| 32 | 2022-03-03 | Marist (197) | 67 | 78 | Canisius (269) | Final | W | 11 |
| 33 | 2022-03-05 | Siena (186) | 64 | 67 | Canisius (269) | Final | W | 3 |
| 34 | 2022-03-08 | Canisius (254) | 50 | 72 | Fairfield (224) | Final | L | -22 |