Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Indianapolis | 46 | 82 | Ohio State (9) | Final | W | 36 |
| 2 | 2021-11-09 | Akron (122) | 66 | 67 | Ohio State (9) | Final | W | 1 |
| 3 | 2021-11-12 | Niagara (342) | 74 | 84 | Ohio State (34) | Final | W | 10 |
| 4 | 2021-11-15 | Bowling Green (270) | 58 | 89 | Ohio State (74) | Final | W | 31 |
| 5 | 2021-11-18 | Ohio State (74) | 65 | 71 | Xavier (86) | Final | L | -6 |
| 6 | 2021-11-22 | Seton Hall (53) | 76 | 79 | Ohio State (34) | Final | W | 3 |
| 7 | 2021-11-24 | Florida (6) | 71 | 68 | Ohio State (34) | Final | L | -3 |
| 8 | 2021-11-30 | Duke (1) | 66 | 71 | Ohio State (63) | Final | W | 5 |
| 9 | 2021-12-05 | Ohio State (63) | 76 | 64 | Penn State (93) | Final | W | 12 |
| 10 | 2021-12-08 | Towson (125) | 74 | 85 | Ohio State (29) | Final | W | 11 |
| 11 | 2021-12-11 | Wisconsin (24) | 55 | 73 | Ohio State (34) | Final | W | 18 |
| 12 | 2021-12-18 | Ohio State | 0 | 0 | Kentucky | Cancelled | - | - |
| 13 | 2021-12-21 | Tennessee-Martin | 0 | 0 | Ohio State | Cancelled | - | - |
| 14 | 2021-12-28 | New Orleans (236) | 0 | 0 | Ohio State (34) | Cancelled | - | - |
| 15 | 2022-01-02 | Ohio State (34) | 87 | 79 | Nebraska (13) | Final/OT | W | 8 |
| 16 | 2022-01-06 | Ohio State (34) | 51 | 67 | Indiana (46) | Final | L | -16 |
| 17 | 2022-01-09 | Northwestern (88) | 87 | 95 | Ohio State (21) | Final | W | 8 |
| 18 | 2022-01-13 | Ohio State (34) | 68 | 78 | Wisconsin (24) | Final | L | -10 |
| 19 | 2022-01-16 | Penn State (71) | 56 | 61 | Ohio State (22) | Final | W | 5 |
| 20 | 2022-01-18 | IUPUI (358) | 37 | 83 | Ohio State (22) | Final | W | 46 |
| 21 | 2022-01-22 | Nebraska (13) | 0 | 0 | Ohio State (34) | Postponed | - | - |
| 22 | 2022-01-27 | Ohio State (34) | 75 | 64 | Minnesota (87) | Final | W | 11 |
| 23 | 2022-01-30 | Ohio State (22) | 78 | 81 | Purdue (8) | Final | L | -3 |
| 24 | 2022-02-03 | Iowa (28) | 0 | 0 | Ohio State (34) | Postponed | - | - |
| 25 | 2022-02-06 | Maryland (114) | 67 | 82 | Ohio State (34) | Final | W | 15 |
| 26 | 2022-02-09 | Ohio State (34) | 64 | 66 | Rutgers (112) | Final | L | -2 |
| 27 | 2022-02-12 | Ohio State (34) | 68 | 57 | Michigan (1) | Final | W | 11 |
| 28 | 2022-02-15 | Minnesota (82) | 45 | 70 | Ohio State (27) | Final | W | 25 |
| 29 | 2022-02-19 | Iowa (30) | 75 | 62 | Ohio State (27) | Final | L | -13 |
| 30 | 2022-02-21 | Indiana (45) | 69 | 80 | Ohio State (24) | Final | W | 11 |
| 31 | 2022-02-24 | Ohio State (24) | 86 | 83 | Illinois (16) | Final | W | 3 |
| 32 | 2022-02-27 | Ohio State (27) | 60 | 75 | Maryland (82) | Final | L | -15 |
| 33 | 2022-03-01 | Nebraska (189) | 78 | 70 | Ohio State (27) | Final | L | -8 |
| 34 | 2022-03-03 | Michigan State (28) | 69 | 80 | Ohio State (27) | Final | W | 11 |
| 35 | 2022-03-06 | Michigan (41) | 75 | 69 | Ohio State (30) | Final | L | -6 |
| 36 | 2022-03-10 | Penn State (100) | 71 | 68 | Ohio State (30) | Final | L | -3 |
| 37 | 2022-03-18 | Loyola-Chicago (43) | 41 | 54 | Ohio State (34) | Final | W | 13 |
| 38 | 2022-03-20 | Ohio State (34) | 61 | 71 | Villanova (7) | Final | L | -10 |