Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | South Carolina State (345) | 62 | 70 | East Carolina (170) | Final | L | -8 |
| 2 | 2021-11-11 | South Carolina State (345) | 74 | 106 | Charleston (223) | Final | L | -32 |
| 3 | 2021-11-12 | South Carolina State (355) | 65 | 75 | Loyola-Maryland (325) | Final | L | -10 |
| 4 | 2021-11-13 | South Carolina State (345) | 81 | 93 | Lipscomb (226) | Final | L | -12 |
| 5 | 2021-11-16 | South Carolina State (355) | 60 | 76 | Georgia (141) | Final | L | -16 |
| 6 | 2021-11-18 | St. Andrews | 53 | 67 | South Carolina State (355) | Final | W | 14 |
| 7 | 2021-11-23 | South Carolina Upstate (300) | 82 | 78 | South Carolina State (354) | Final | L | -4 |
| 8 | 2021-11-28 | The Citadel (152) | 91 | 79 | South Carolina State (353) | Final (OT) | L | -12 |
| 9 | 2021-12-03 | South Carolina State (355) | 65 | 64 | South Florida (52) | Final | W | 1 |
| 10 | 2021-12-10 | High Point (245) | 66 | 67 | South Carolina State (332) | Final | W | 1 |
| 11 | 2021-12-14 | South Carolina State (355) | 62 | 103 | Duke (3) | Final | L | -41 |
| 12 | 2021-12-16 | Carver Bible | 46 | 105 | South Carolina State (355) | Final | W | 59 |
| 13 | 2021-12-18 | Tennessee State (165) | 88 | 90 | South Carolina State (355) | Final/OT | W | 2 |
| 14 | 2021-12-20 | South Carolina State (355) | 74 | 57 | The Citadel (332) | Final | W | 17 |
| 15 | 2021-12-21 | South Carolina State (355) | 75 | 65 | Charleston Southern (262) | Final | W | 10 |
| 16 | 2021-12-29 | South Carolina State (355) | 0 | 0 | South Carolina (110) | Cancelled | - | - |
| 17 | 2022-01-02 | Greensboro | 0 | 0 | South Carolina State (355) | Postponed | - | - |
| 18 | 2022-01-08 | Coppin State (360) | 74 | 65 | South Carolina State (355) | Final | L | -9 |
| 19 | 2022-01-10 | Morgan State (329) | 88 | 81 | South Carolina State (304) | Final (OT) | L | -7 |
| 20 | 2022-01-15 | North Carolina Central (341) | 0 | 0 | South Carolina State (355) | Postponed | - | - |
| 21 | 2022-01-18 | Morris College | 67 | 102 | South Carolina State (355) | Final | W | 35 |
| 22 | 2022-01-22 | South Carolina State (355) | 69 | 60 | Maryland-Eastern Shore (353) | Final | W | 9 |
| 23 | 2022-01-24 | South Carolina State (355) | 64 | 62 | Delaware State (361) | Final | W | 2 |
| 24 | 2022-01-29 | Norfolk State (322) | 87 | 69 | South Carolina State (355) | Final | L | -18 |
| 25 | 2022-01-31 | Howard (253) | 55 | 58 | South Carolina State (297) | Final | W | 3 |
| 26 | 2022-02-07 | North Carolina Central (341) | 68 | 74 | South Carolina State (355) | Final | W | 6 |
| 27 | 2022-02-12 | South Carolina State (355) | 66 | 58 | Coppin State (360) | Final | W | 8 |
| 28 | 2022-02-14 | South Carolina State (355) | 66 | 76 | Morgan State (337) | Final | L | -10 |
| 29 | 2022-02-19 | Maryland-Eastern Shore (288) | 63 | 70 | South Carolina State (287) | Final | W | 7 |
| 30 | 2022-02-21 | Delaware State (358) | 74 | 79 | South Carolina State (296) | Final | W | 5 |
| 31 | 2022-02-26 | South Carolina State (296) | 59 | 63 | Norfolk State (153) | Final | L | -4 |
| 32 | 2022-02-28 | South Carolina State (290) | 62 | 72 | Howard (243) | Final | L | -10 |
| 33 | 2022-03-03 | South Carolina State (290) | 62 | 67 | North Carolina Central (275) | Final | L | -5 |
| 34 | 2022-03-10 | South Carolina State (297) | 77 | 80 | Morgan State (298) | Final | L | -3 |