Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Cleveland State (139) | 59 | 69 | BYU (13) | Final | L | -10 |
| 2 | 2021-11-13 | Ohio (95) | 67 | 56 | Cleveland State (139) | Final | L | -11 |
| 3 | 2021-11-14 | Ohio (95) | 67 | 56 | Cleveland State (139) | Final | L | -11 |
| 4 | 2021-11-16 | Edinboro | 61 | 75 | Cleveland State (291) | Final | W | 14 |
| 5 | 2021-11-20 | Canisius (328) | 70 | 80 | Cleveland State (308) | Final | W | 10 |
| 6 | 2021-11-22 | Coppin State (360) | 62 | 65 | Cleveland State (308) | Final | W | 3 |
| 7 | 2021-11-27 | Penn State-Behrend | 47 | 89 | Cleveland State (239) | Final | W | 42 |
| 8 | 2021-12-02 | Northern Kentucky (218) | 58 | 72 | Cleveland State (202) | Final | W | 14 |
| 9 | 2021-12-04 | Wright State (124) | 75 | 85 | Cleveland State (308) | Final | W | 10 |
| 10 | 2021-12-13 | Cleveland State (308) | 93 | 98 | Oklahoma State (57) | Final/OT | L | -5 |
| 11 | 2021-12-18 | Cleveland State | 0 | 0 | Duke | Cancelled | - | - |
| 12 | 2021-12-21 | Cleveland State | 0 | 0 | Kent State | Cancelled | - | - |
| 13 | 2021-12-30 | Purdue Fort Wayne (222) | 81 | 90 | Cleveland State (308) | Final | W | 9 |
| 14 | 2021-12-30 | Cleveland State | 0 | 0 | IUPUI | Cancelled | - | - |
| 15 | 2022-01-01 | Cleveland State (308) | 0 | 0 | Illinois-Chicago (139) | Canceled | - | - |
| 16 | 2022-01-05 | Purdue Fort Wayne (222) | 58 | 65 | Cleveland State (308) | Final | W | 7 |
| 17 | 2022-01-07 | Cleveland State (308) | 78 | 77 | Robert Morris (148) | Final | W | 1 |
| 18 | 2022-01-09 | Cleveland State (133) | 86 | 80 | Youngstown State (238) | Final (OT) | W | 6 |
| 19 | 2022-01-13 | Oakland (172) | 70 | 65 | Cleveland State (308) | Final | L | -5 |
| 20 | 2022-01-15 | Detroit (212) | 70 | 72 | Cleveland State (308) | Final | W | 2 |
| 21 | 2022-01-21 | Youngstown State (241) | 61 | 64 | Cleveland State (136) | Final | W | 3 |
| 22 | 2022-01-23 | Robert Morris (337) | 68 | 75 | Cleveland State (128) | Final | W | 7 |
| 23 | 2022-01-28 | Cleveland State (128) | 71 | 67 | Wright State (224) | Final | W | 4 |
| 24 | 2022-01-30 | Cleveland State (135) | 72 | 78 | Northern Kentucky (246) | Final | L | -6 |
| 25 | 2022-02-04 | Green Bay (340) | 69 | 85 | Cleveland State (135) | Final | W | 16 |
| 26 | 2022-02-06 | Milwaukee (261) | 71 | 84 | Cleveland State (308) | Final | W | 13 |
| 27 | 2022-02-10 | Illinois-Chicago (139) | 76 | 75 | Cleveland State (308) | Final | L | -1 |
| 28 | 2022-02-12 | IUPUI (358) | 45 | 83 | Cleveland State (130) | Final | W | 38 |
| 29 | 2022-02-14 | Cleveland State (308) | 98 | 102 | Purdue Fort Wayne (222) | Final/3OT | L | -4 |
| 30 | 2022-02-18 | Cleveland State (143) | 78 | 61 | Milwaukee (317) | Final | W | 17 |
| 31 | 2022-02-20 | Cleveland State (161) | 79 | 67 | Green Bay (349) | Final | W | 12 |
| 32 | 2022-02-24 | Cleveland State (161) | 67 | 74 | Detroit (244) | Final | L | -7 |
| 33 | 2022-02-26 | Cleveland State (161) | 57 | 65 | Oakland (143) | Final | L | -8 |
| 34 | 2022-03-03 | Robert Morris (342) | 67 | 83 | Cleveland State (180) | Final | W | 16 |
| 35 | 2022-03-07 | Wright State (203) | 82 | 67 | Cleveland State (180) | Final | L | -15 |
| 36 | 2022-03-15 | Cleveland State (190) | 68 | 72 | Xavier (42) | Final | L | -4 |