Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Cal State-Fullerton (257) | 77 | 84 | Santa Clara (126) | Final | L | -7 |
| 2 | 2021-11-11 | Cal State-Fullerton (257) | 76 | 78 | San Jose State (325) | Final | L | -2 |
| 3 | 2021-11-16 | George Washington (207) | 59 | 74 | Cal State-Fullerton (281) | Final | W | 15 |
| 4 | 2021-11-19 | Cal State-Fullerton (194) | 57 | 55 | San Diego (246) | Final | W | 2 |
| 5 | 2021-11-23 | Cal State-Fullerton (163) | 67 | 72 | UTRGV (301) | Final | L | -5 |
| 6 | 2021-11-24 | Cal State-Fullerton (194) | 73 | 56 | Northern Arizona (324) | Final | W | 17 |
| 7 | 2021-11-29 | Wyoming (32) | 79 | 66 | Cal State-Fullerton (184) | Final | L | -13 |
| 8 | 2021-12-04 | Pacific (132) | 57 | 66 | Cal State-Fullerton (194) | Final | W | 9 |
| 9 | 2021-12-08 | Cal State-Fullerton (184) | 56 | 66 | San Diego State (111) | Final | L | -10 |
| 10 | 2021-12-11 | Life Pacific | 59 | 87 | Cal State-Fullerton (194) | Final | W | 28 |
| 11 | 2021-12-17 | Redlands | 78 | 93 | Cal State-Fullerton (194) | Final | W | 15 |
| 12 | 2021-12-21 | Cal State-Fullerton | 0 | 0 | New Mexico State | Cancelled | - | - |
| 13 | 2021-12-30 | Cal State-Fullerton (194) | 73 | 67 | Cal State-Bakersfield (333) | Final | W | 6 |
| 14 | 2022-01-01 | Cal State-Fullerton (194) | 0 | 0 | Cal Poly (238) | Canceled | - | - |
| 15 | 2022-01-04 | Long Beach State (278) | 0 | 0 | Cal State-Fullerton (194) | Canceled | - | - |
| 16 | 2022-01-06 | Hawaii (109) | 0 | 0 | Cal State-Fullerton (194) | Canceled | - | - |
| 17 | 2022-01-13 | Cal State-Northridge (180) | 64 | 79 | Cal State-Fullerton (194) | Final | W | 15 |
| 18 | 2022-01-15 | UC-Santa Barbara (171) | 73 | 79 | Cal State-Fullerton (194) | Final | W | 6 |
| 19 | 2022-01-20 | Cal State-Fullerton (194) | 65 | 63 | UC-Irvine (119) | Final | W | 2 |
| 20 | 2022-01-22 | UC-San Diego (126) | 80 | 83 | Cal State-Fullerton (194) | Final | W | 3 |
| 21 | 2022-01-27 | Cal State-Fullerton (194) | 74 | 58 | UC-Davis (170) | Final | W | 16 |
| 22 | 2022-01-29 | Cal State-Fullerton (194) | 54 | 67 | UC-Riverside (292) | Final | L | -13 |
| 23 | 2022-02-03 | Cal Poly (238) | 50 | 61 | Cal State-Fullerton (194) | Final | W | 11 |
| 24 | 2022-02-05 | Cal State-Bakersfield (333) | 61 | 75 | Cal State-Fullerton (194) | Final | W | 14 |
| 25 | 2022-02-08 | Cal State-Fullerton (160) | 61 | 71 | Long Beach State (172) | Final | L | -10 |
| 26 | 2022-02-12 | Cal State-Fullerton (194) | 55 | 72 | Hawaii (109) | Final | L | -17 |
| 27 | 2022-02-13 | Cal State-Fullerton (183) | 55 | 72 | Hawaii (185) | Final | L | -17 |
| 28 | 2022-02-17 | Cal State-Fullerton (194) | 67 | 58 | UC-Santa Barbara (171) | Final | W | 9 |
| 29 | 2022-02-19 | Cal State-Fullerton (183) | 81 | 73 | Cal State-Northridge (314) | Final | W | 8 |
| 30 | 2022-02-24 | UC-Irvine (124) | 64 | 66 | Cal State-Fullerton (166) | Final | W | 2 |
| 31 | 2022-02-26 | Cal State-Fullerton (166) | 76 | 81 | UC-San Diego (269) | Final | L | -5 |
| 32 | 2022-03-03 | UC-Riverside (185) | 75 | 72 | Cal State-Fullerton (170) | Final | L | -3 |
| 33 | 2022-03-05 | UC-Davis (231) | 59 | 62 | Cal State-Fullerton (170) | Final | W | 3 |
| 34 | 2022-03-10 | UC-Davis (239) | 55 | 73 | Cal State-Fullerton (182) | Final | W | 18 |
| 35 | 2022-03-11 | Hawaii (191) | 46 | 58 | Cal State-Fullerton (182) | Final | W | 12 |
| 36 | 2022-03-12 | Cal State-Fullerton (182) | 72 | 71 | Long Beach State (143) | Final | W | 1 |
| 37 | 2022-03-18 | Cal State-Fullerton (154) | 61 | 78 | Duke (13) | Final | L | -17 |