Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Lafayette (182) | 63 | 97 | Syracuse (45) | Final | L | -34 |
| 2 | 2021-11-12 | Cornell (187) | 90 | 85 | Lafayette (323) | Final | L | -5 |
| 3 | 2021-11-16 | Lafayette (299) | 57 | 85 | Penn (261) | Final | L | -28 |
| 4 | 2021-11-19 | Lafayette (323) | 55 | 88 | Duke (3) | Final | L | -33 |
| 5 | 2021-11-22 | Lafayette (323) | 53 | 51 | Rutgers (112) | Final | W | 2 |
| 6 | 2021-11-29 | Lafayette (293) | 73 | 50 | Columbia (315) | Final | W | 23 |
| 7 | 2021-12-02 | Sacred Heart (282) | 74 | 67 | Lafayette (293) | Final | L | -7 |
| 8 | 2021-12-05 | NJIT (265) | 90 | 86 | Lafayette (293) | Final (2OT) | L | -4 |
| 9 | 2021-12-08 | Lafayette (294) | 58 | 68 | Delaware (114) | Final | L | -10 |
| 10 | 2021-12-11 | Princeton (271) | 84 | 73 | Lafayette (323) | Final | L | -11 |
| 11 | 2021-12-22 | Gwynedd-Mercy | 66 | 87 | Lafayette (323) | Final | W | 21 |
| 12 | 2022-01-01 | Colgate (239) | 0 | 0 | Lafayette (323) | Postponed | - | - |
| 13 | 2022-01-04 | Lafayette (323) | 0 | 0 | American (249) | Postponed | - | - |
| 14 | 2022-01-07 | Lafayette (323) | 74 | 79 | Holy Cross (334) | Final | L | -5 |
| 15 | 2022-01-10 | Navy (112) | 69 | 55 | Lafayette (318) | Final | L | -14 |
| 16 | 2022-01-13 | Lafayette (323) | 60 | 74 | Loyola-Maryland (325) | Final | L | -14 |
| 17 | 2022-01-16 | Army (248) | 54 | 68 | Lafayette (313) | Final | W | 14 |
| 18 | 2022-01-19 | Holy Cross (334) | 0 | 0 | Lafayette (323) | Postponed | - | - |
| 19 | 2022-01-22 | Lafayette (323) | 0 | 0 | Colgate (239) | Postponed | - | - |
| 20 | 2022-01-24 | Lafayette (323) | 69 | 56 | American (249) | Final | W | 13 |
| 21 | 2022-01-26 | Boston University (198) | 81 | 62 | Lafayette (316) | Final | L | -19 |
| 22 | 2022-01-29 | Lafayette (323) | 56 | 60 | Army (339) | Final | L | -4 |
| 23 | 2022-01-31 | Colgate (229) | 72 | 61 | Lafayette (315) | Final | L | -11 |
| 24 | 2022-02-02 | American (326) | 62 | 71 | Lafayette (315) | Final | W | 9 |
| 25 | 2022-02-05 | Bucknell (336) | 72 | 74 | Lafayette (323) | Final/OT | W | 2 |
| 26 | 2022-02-07 | Lafayette (323) | 44 | 68 | Navy (149) | Final | L | -24 |
| 27 | 2022-02-12 | Lafayette (323) | 73 | 69 | Lehigh (276) | Final | W | 4 |
| 28 | 2022-02-14 | Lafayette (323) | 61 | 69 | Colgate (239) | Final | L | -8 |
| 29 | 2022-02-16 | Loyola-Maryland (265) | 68 | 77 | Lafayette (306) | Final | W | 9 |
| 30 | 2022-02-19 | Lafayette (306) | 89 | 92 | Bucknell (334) | Final | L | -3 |
| 31 | 2022-02-21 | Holy Cross (326) | 61 | 84 | Lafayette (307) | Final | W | 23 |
| 32 | 2022-02-23 | Lafayette (307) | 60 | 76 | Boston University (202) | Final | L | -16 |
| 33 | 2022-02-26 | Lehigh (309) | 78 | 58 | Lafayette (307) | Final | L | -20 |
| 34 | 2022-03-01 | Bucknell (331) | 82 | 81 | Lafayette (311) | Final | L | -1 |